(35 nodes) Regulation of keratinocyte differentiation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Msx2	Homeobox protein MSX-2. (267 aa)
	I79_026151	ETS translocation variant 4. (69 aa)
	I79_026146	ETS translocation variant 4. (95 aa)
	I79_025795	Vitamin D3 receptor. (86 aa)
	Krt84	Keratin, type II cuticular Hb4; Belongs to the intermediate filament family. (602 aa)
	Errfi1	ERBB receptor feedback inhibitor 1. (460 aa)
	Vdr	Vitamin D3 receptor. (372 aa)
	I79_019820	Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (467 aa)
	I79_017912	Nuclear mitotic apparatus protein 1; Belongs to the transient receptor (TC 1.A.4) family. (3026 aa)
	I79_017652	Grainyhead-like protein 1-like. (447 aa)
	I79_017374	ATP-binding cassette sub-family A member 12. (506 aa)
	Prkch	Protein kinase C eta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (635 aa)
	I79_015207	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
	I79_015031	ATP-binding cassette sub-family A member 12. (892 aa)
	I79_014743	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
	I79_011377	Grainyhead-like protein 2-like. (522 aa)
	Zfp36	Tristetraproline. (315 aa)
	Cd109	CD109 antigen. (1443 aa)
	Srsf6	Splicing factor, arginine/serine-rich 6. (210 aa)
	Hoxa7	Homeobox protein Hox-A7. (112 aa)
	I79_007624	Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
	Ncoa3	Nuclear receptor coactivator 3. (1211 aa)
	I79_006792	DUF1518 domain-containing protein. (200 aa)
	I79_006049	Core histone macro-H2A.2. (393 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	I79_005352	Sphingosine-1-phosphate phosphatase 1. (241 aa)
	Zfp36l1	Butyrate response factor 1. (338 aa)
	I79_003879	Core histone macro-H2A.1. (155 aa)
	I79_003878	Histone H2A; Belongs to the histone H2A family. (242 aa)
	I79_002727	Arachidonate 15-lipoxygenase type II. (407 aa)
	Ezh2	Histone-lysine N-methyltransferase EZH2. (746 aa)
	I79_001871	Transcription factor Ovo-like 2. (213 aa)
	Trim16	Tripartite motif-containing protein 16. (274 aa)
	I79_001756	Tripartite motif-containing protein 16. (197 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ezh2	I79_003878	G3GXG1	G3H154	Histone-lysine N-methyltransferase EZH2.	Histone H2A; Belongs to the histone H2A family.	0.541
Ezh2	I79_003879	G3GXG1	G3H155	Histone-lysine N-methyltransferase EZH2.	Core histone macro-H2A.1.	0.541
Ezh2	I79_006049	G3GXG1	G3H6T0	Histone-lysine N-methyltransferase EZH2.	Core histone macro-H2A.2.	0.541
I79_001756	Trim16	G3GVL4	G3GVL5	Tripartite motif-containing protein 16.	Tripartite motif-containing protein 16.	0.622
I79_001871	I79_011377	G3GVW7	G3HKZ4	Transcription factor Ovo-like 2.	Grainyhead-like protein 2-like.	0.445
I79_003878	Ezh2	G3H154	G3GXG1	Histone H2A; Belongs to the histone H2A family.	Histone-lysine N-methyltransferase EZH2.	0.541
I79_003879	Ezh2	G3H155	G3GXG1	Core histone macro-H2A.1.	Histone-lysine N-methyltransferase EZH2.	0.541
I79_006049	Ezh2	G3H6T0	G3GXG1	Core histone macro-H2A.2.	Histone-lysine N-methyltransferase EZH2.	0.541
I79_006792	I79_015207	G3H8T1	G3HW59	DUF1518 domain-containing protein.	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	0.475
I79_006792	I79_025795	G3H8T1	G3IP90	DUF1518 domain-containing protein.	Vitamin D3 receptor.	0.693
I79_006792	I79_026146	G3H8T1	G3IQ55	DUF1518 domain-containing protein.	ETS translocation variant 4.	0.563
I79_006792	I79_026151	G3H8T1	G3IQ59	DUF1518 domain-containing protein.	ETS translocation variant 4.	0.563
I79_006792	Med1	G3H8T1	G3H5X2	DUF1518 domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.606
I79_006792	Ncoa3	G3H8T1	G3H8T2	DUF1518 domain-containing protein.	Nuclear receptor coactivator 3.	0.941
I79_006792	Vdr	G3H8T1	G3IE51	DUF1518 domain-containing protein.	Vitamin D3 receptor.	0.693
I79_007624	I79_014743	G3HB11	G3HUX3	Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.863
I79_011377	I79_001871	G3HKZ4	G3GVW7	Grainyhead-like protein 2-like.	Transcription factor Ovo-like 2.	0.445
I79_014743	I79_007624	G3HUX3	G3HB11	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.863
I79_015031	I79_017374	G3HVP1	G3I1V5	ATP-binding cassette sub-family A member 12.	ATP-binding cassette sub-family A member 12.	0.919
I79_015207	I79_006792	G3HW59	G3H8T1	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	DUF1518 domain-containing protein.	0.475