STRINGSTRING
Trib1 Trib1 Casp8 Casp8 Jag1 Jag1 I79_001200 I79_001200 Smap1 Smap1 Cd4 Cd4 I79_002219 I79_002219 Abcb10 Abcb10 Foxo3 Foxo3 Asxl2 Asxl2 Tal1 Tal1 Traf6 Traf6 I79_003375 I79_003375 Zfp36l1 Zfp36l1 I79_004475 I79_004475 I79_004680 I79_004680 Med1 Med1 Ets1 Ets1 Ocstamp Ocstamp Il34 Il34 Gsk3b Gsk3b Rab7b Rab7b Fam210b Fam210b Hax1 Hax1 IL12B IL12B Scin Scin Mpl Mpl Fos Fos Faxdc2 Faxdc2 Ikzf1 Ikzf1 Tnfsf11 Tnfsf11 I79_009953 I79_009953 Gata2 Gata2 Kitlg Kitlg Kdm1a Kdm1a I79_010901 I79_010901 I79_011711 I79_011711 I79_011712 I79_011712 Stat3 Stat3 I79_011789 I79_011789 Gata1 Gata1 Runx1 Runx1 Ninj1 Ninj1 Notch2 Notch2 Fadd Fadd Rb1 Rb1 I79_013410 I79_013410 Il23a Il23a Ppargc1b Ppargc1b I79_013650 I79_013650 I79_013659 I79_013659 Cd74 Cd74 I79_013771 I79_013771 Nedd9 Nedd9 I79_014474 I79_014474 Inhba Inhba I79_014943 I79_014943 I79_015223 I79_015223 I79_015356 I79_015356 I79_015453 I79_015453 I79_015454 I79_015454 Acvr2a Acvr2a I79_016051 I79_016051 Evi2b Evi2b Hif1a Hif1a I79_016446 I79_016446 Hspa1a Hspa1a Tnf Tnf I79_016597 I79_016597 Mapk14 Mapk14 Lif Lif Il17a Il17a Pla2g3 Pla2g3 I79_017613 I79_017613 I79_017833 I79_017833 Gpr68 Gpr68 I79_018047 I79_018047 Klf10 Klf10 Isg15 Isg15 I79_018546 I79_018546 I79_018885 I79_018885 CgPICR_003405 CgPICR_003405 I79_019038 I79_019038 Ccl5 Ccl5 Stat1 Stat1 Tgfb1 Tgfb1 I79_020506 I79_020506 Brd1 Brd1 Ripk1 Ripk1 Gfi1b Gfi1b I79_022515 I79_022515 Fes Fes I79_022988 I79_022988 Prmt1 Prmt1 Csf1 Csf1 I79_023475 I79_023475 I79_023775 I79_023775 Inpp5d Inpp5d Ctnnbip1 Ctnnbip1 I79_025387 I79_025387 Acvr1b Acvr1b Csf3 Csf3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Trib1Tribbles-like 1. (286 aa)
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
I79_001200Tescalcin. (210 aa)
Smap1Stromal membrane-associated protein 1. (325 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
I79_002219Neuroendocrine secretory protein 55. (295 aa)
Abcb10ATP-binding cassette sub-family B member 10, mitochondrial. (283 aa)
Foxo3Forkhead box protein O3. (672 aa)
Asxl2Putative Polycomb group protein ASXL2. (1421 aa)
Tal1T-cell acute lymphocytic leukemia protein 1-like. (329 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
I79_003375Interleukin-20. (147 aa)
Zfp36l1Butyrate response factor 1. (338 aa)
I79_004475Carbonic anhydrase 2. (220 aa)
I79_004680REST corepressor 1. (293 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
Ets1Protein C-ets-1. (257 aa)
OcstampTransmembrane protein C20orf123-like. (519 aa)
Il34Interleukin-34. (201 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Rab7bRas-related protein Rab-7b. (199 aa)
Fam210bTransmembrane protein C20orf108-like. (171 aa)
Hax1HCLS1-associated protein X-1. (105 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
ScinAdseverin. (715 aa)
MplThrombopoietin receptor. (647 aa)
FosProto-oncogene protein c-fos. (381 aa)
Faxdc2Uncharacterized protein C5orf4-like; Belongs to the sterol desaturase family. (319 aa)
Ikzf1DNA-binding protein Ikaros. (489 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
I79_009953Transcription factor AP-1. (72 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (750 aa)
I79_010901Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (584 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
Gata1Erythroid transcription factor-like protein. (330 aa)
Runx1Runt-related transcription factor 1. (462 aa)
Ninj1Ninjurin-1. (102 aa)
Notch2Neurogenic locus notch-like protein 2. (1521 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Rb1Retinoblastoma-associated protein. (302 aa)
I79_013410Apoptotic chromatin condensation inducer in the nucleus. (1230 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
Ppargc1bPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (843 aa)
I79_013650Peroxisome proliferator-activated receptor gamma coactivator 1-beta. (111 aa)
I79_013659Macrophage colony-stimulating factor 1 receptor. (595 aa)
Cd74H-2 class II histocompatibility antigen gamma chain. (329 aa)
I79_013771Calcitonin. (206 aa)
Nedd9Enhancer of filamentation 1. (830 aa)
I79_014474Cyclic AMP-responsive element-binding protein 1. (325 aa)
InhbaInhibin beta A chain-like protein. (424 aa)
I79_014943Transmembrane 7 superfamily member 4. (243 aa)
I79_015223Neurogenic locus notch-like protein 2. (248 aa)
I79_015356Heat shock factor protein 1. (524 aa)
I79_015453C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
I79_015454C-C chemokine receptor 1-like protein 1; Belongs to the G-protein coupled receptor 1 family. (329 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
I79_016051Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (777 aa)
Evi2bProtein EVI2B. (172 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
I79_016446Heat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (641 aa)
Hspa1aHeat shock 70 kDa protein 1A/1B; Belongs to the heat shock protein 70 family. (641 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
I79_016597Krueppel-like factor 10. (439 aa)
Mapk14Mitogen-activated protein kinase. (349 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
Il17aInterleukin-17A. (158 aa)
Pla2g3Group 3 secretory phospholipase A2. (398 aa)
I79_017613DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3486 aa)
I79_017833Lymphoid enhancer-binding factor 1. (276 aa)
Gpr68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
I79_018047Krueppel-like factor 10. (94 aa)
Klf10Krueppel-like factor 10. (212 aa)
Isg15Ubiquitin-like protein ISG15-like protein. (156 aa)
I79_018546Ankyrin repeat domain-containing protein 54. (280 aa)
I79_018885Transmembrane protein 64. (105 aa)
CgPICR_003405C-C motif chemokine. (98 aa)
I79_019038Nck-associated protein 1-like. (1065 aa)
Ccl5C-C motif chemokine. (91 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
I79_020506POU domain, class 4, transcription factor 2. (207 aa)
Brd1Bromodomain-containing protein 1. (1151 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (655 aa)
Gfi1bZinc finger protein Gfi-1b. (330 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
FesTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
I79_022988Mitochondrial sodium/hydrogen exchanger NHA2. (494 aa)
Prmt1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (353 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
I79_023775Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (256 aa)
Inpp5dPhosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
Ctnnbip1Beta-catenin-interacting protein 1. (81 aa)
I79_025387Krueppel-like factor 10. (314 aa)
Acvr1bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (373 aa)
Csf3Granulocyte colony-stimulating factor. (208 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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