(51 nodes) Regulation of myoblast differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sra1	Steroid receptor RNA activator 1. (244 aa)
	Neu2	Sialidase-2. (379 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	Kat5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	Prickle1	Prickle-like protein 1. (619 aa)
	Lrrc8a	Leucine-rich repeat-containing protein 8A. (810 aa)
	Mstn	Growth/differentiation factor 8. (295 aa)
	Il36g	Interleukin-1. (143 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Tmem182	Transmembrane protein 182. (201 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	Mef2c	Myocyte-specific enhancer factor 2C. (465 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	Tnfsf14	Tumor necrosis factor ligand superfamily member 14. (238 aa)
	H671_3g11194	Protein FAM65B-like protein. (890 aa)
	Cdon	Cell adhesion molecule-related/down-regulated by oncogenes. (1254 aa)
	Ccl17	C-C motif chemokine. (93 aa)
	Cxcl14	C-X-C motif chemokine 14. (155 aa)
	Btg1	Protein BTG1. (97 aa)
	I79_010844	SET and MYND domain-containing protein 1. (467 aa)
	Mkx	Homeobox protein Mohawk. (352 aa)
	Myog	Myogenin. (224 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Xkr8	XK-related protein. (222 aa)
	Zfp36l1	Butyrate response factor 1. (338 aa)
	I79_003794	Calpain-3; Belongs to the peptidase C2 family. (934 aa)
	Boc	Brother of CDO. (1070 aa)
	Hoga1	Dihydrodipicolinate synthase-like, mitochondrial. (804 aa)
	I79_003100	Myocardin. (371 aa)
	Tbx3	T-box transcription factor TBX3. (709 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	I79_000439	Phosphoinositide phospholipase C. (949 aa)
	Nr2c2	Nuclear receptor subfamily 2 group C member 2. (596 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	Id3	DNA-binding protein inhibitor ID-3. (119 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Mbnl3	Muscleblind-like protein 3. (294 aa)
	Cmtm5	CKLF-like MARVEL transmembrane domain-containing protein 5. (229 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	Nmrk2	Nicotinamide riboside kinase 2. (177 aa)
	Ddit3	DNA damage-inducible transcript 3. (167 aa)
	Sostdc1	Sclerostin domain-containing protein 1. (193 aa)
	Myf5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	Myf6	Myogenic factor 6. (182 aa)
	Hif1an	Hypoxia-inducible factor 1-alpha inhibitor. (312 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	Flt3lg	SL cytokine. (230 aa)
	Gdf3	Growth/differentiation factor 3. (361 aa)
	I79_017350	Myoblast determination protein 1. (112 aa)
	Flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Boc	Cdon	G3H097	G3HFJ8	Brother of CDO.	Cell adhesion molecule-related/down-regulated by oncogenes.	0.972
Ccl17	Cxcl14	G3HIL3	G3HIZ3	C-C motif chemokine.	C-X-C motif chemokine 14.	0.930
Ccl17	Tnf	G3HIL3	G3HZG9	C-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.451
Cdon	Boc	G3HFJ8	G3H097	Cell adhesion molecule-related/down-regulated by oncogenes.	Brother of CDO.	0.972
Cdon	Mef2c	G3HFJ8	G3HAW1	Cell adhesion molecule-related/down-regulated by oncogenes.	Myocyte-specific enhancer factor 2C.	0.430
Cxcl14	Ccl17	G3HIZ3	G3HIL3	C-X-C motif chemokine 14.	C-C motif chemokine.	0.930
Ddit3	Mapk14	G3HW45	G3HZU1	DNA damage-inducible transcript 3.	Mitogen-activated protein kinase.	0.943
Dll1	Flt3lg	G3HNT7	G3I001	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	SL cytokine.	0.445
Flt3lg	Dll1	G3I001	G3HNT7	SL cytokine.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.445
I79_003100	Mef2c	G3GZ48	G3HAW1	Myocardin.	Myocyte-specific enhancer factor 2C.	0.564
I79_006254	Tbx3	G3H7C4	G3GU43	Bone morphogenetic protein 4.	T-box transcription factor TBX3.	0.527
I79_017350	Mapk14	G3I1T1	G3HZU1	Myoblast determination protein 1.	Mitogen-activated protein kinase.	0.578
I79_017350	Mef2c	G3I1T1	G3HAW1	Myoblast determination protein 1.	Myocyte-specific enhancer factor 2C.	0.691
I79_017350	Mstn	G3I1T1	G3IJ34	Myoblast determination protein 1.	Growth/differentiation factor 8.	0.590
I79_017350	Myf6	G3I1T1	G3HZ89	Myoblast determination protein 1.	Myogenic factor 6.	0.641
I79_017350	Myog	G3I1T1	G3H3L0	Myoblast determination protein 1.	Myogenin.	0.762
Il18	Tnf	G3H2H9	G3HZG9	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.762
Il36g	Tnf	G3IKA6	G3HZG9	Interleukin-1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.435
Mapk14	Ddit3	G3HZU1	G3HW45	Mitogen-activated protein kinase.	DNA damage-inducible transcript 3.	0.943
Mapk14	I79_017350	G3HZU1	G3I1T1	Mitogen-activated protein kinase.	Myoblast determination protein 1.	0.578