(84 nodes) Negative regulation of neuron differentiation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Dlx1	Homeobox protein DLX-1. (255 aa)
	Dlx2	Homeobox protein DLX-2. (347 aa)
	I79_002496	Nuclear receptor subfamily 2 group E member 1. (323 aa)
	Foxo3	Forkhead box protein O3. (672 aa)
	Pax6	Paired box protein Pax-6. (544 aa)
	Nepro	Uncharacterized protein C3orf17. (492 aa)
	Isl2	Insulin gene enhancer protein ISL-2. (200 aa)
	Hmg20a	High mobility group protein 20A. (347 aa)
	I79_003731	Iroquois-class homeodomain protein IRX-3. (341 aa)
	B2m	Beta-2-microglobulin. (54 aa)
	Meis1	Homeobox protein Meis1. (390 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	Isl1	Insulin gene enhancer protein ISL-1. (257 aa)
	Dixdc1	Dixin. (689 aa)
	I79_004643	Contactin-4. (822 aa)
	Gpr37l1	Endothelin B receptor-like protein 2. (481 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	Ascl1	Achaete-scute-like 1. (140 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	CgPICR_006170	Fez family zinc finger protein 2. (455 aa)
	I79_006472	Polypyrimidine tract-binding protein 1. (119 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Gsk3b	Glycogen synthase kinase-3 beta. (328 aa)
	Cntn2	Contactin-2. (1008 aa)
	Spag9	C-jun-amino-terminal kinase-interacting protein 4. (1155 aa)
	Bmp7	Bone morphogenetic protein 7. (430 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	Calr	Calreticulin. (417 aa)
	Hoxa2	Homeobox protein Hox-A2. (76 aa)
	Ptbp1	Polypyrimidine tract-binding protein 1. (528 aa)
	I79_009702	E3 ubiquitin-protein ligase MIB1. (739 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	I79_010207	Eukaryotic translation initiation factor 2-alpha kinase 4. (1513 aa)
	I79_010490	Rap1 GTPase-activating protein 1. (743 aa)
	I79_010923	Reticulon. (68 aa)
	Rtn4	Reticulon-4. (806 aa)
	Sox2	Transcription factor SOX-2. (273 aa)
	Pbx1	Pre-B-cell leukemia transcription factor 1. (325 aa)
	I79_011753	Abnormal spindle-like microcephaly-associated protein-like. (416 aa)
	Aspm	Abnormal spindle-like microcephaly-associated protein-like. (1831 aa)
	I79_011789	DNA-binding protein inhibitor ID-2. (185 aa)
	I79_011804	Neurogenic locus notch-like protein 3. (2181 aa)
	App	Amyloid beta A4 protein. (433 aa)
	I79_012168	Fragile X mental retardation 1 protein. (560 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	I79_012607	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (568 aa)
	I79_012761	LIM homeobox transcription factor 1-alpha. (88 aa)
	Lmx1a	LIM homeobox transcription factor 1-alpha. (333 aa)
	Slc6a4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (520 aa)
	Gdf11	Growth/differentiation factor 11. (268 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Zhx2	Zinc fingers and homeoboxes protein 2. (837 aa)
	I79_015033	Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Ttc3	Tetratricopeptide repeat protein 3. (1499 aa)
	Foxa2	Hepatocyte nuclear factor 3-beta. (430 aa)
	Cdk5rap2	CDK5 regulatory subunit-associated protein 2. (1379 aa)
	Itgb1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	Dmd	Dystrophin. (617 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	I79_017166	Zinc finger protein 536. (372 aa)
	Eif4enif1	Eukaryotic translation initiation factor 4E transporter. (984 aa)
	Ddx6	Putative ATP-dependent RNA helicase DDX6-like protein; Belongs to the DEAD box helicase family. (483 aa)
	Casz1	Zinc finger protein castor-like 1. (1520 aa)
	H671_4g12762	Protein deltex-1-like protein. (466 aa)
	CgPICR_014162	Polypyrimidine tract-binding protein 1. (575 aa)
	Rest	RE1-silencing transcription factor. (1047 aa)
	I79_020068	Zinc finger protein 536. (358 aa)
	I79_020506	POU domain, class 4, transcription factor 2. (207 aa)
	I79_020539	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
	I79_020662	Protein fucU-like. (159 aa)
	I79_021692	Transcription factor LBX1. (90 aa)
	I79_022157	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (354 aa)
	I79_022161	Dystrophin. (655 aa)
	I79_023241	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (558 aa)
	I79_023431	Polypyrimidine tract-binding protein 1. (323 aa)
	Eif4e	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
	Cntf	Ciliary neurotrophic factor. (59 aa)
	Hes3	Transcription factor HES-3. (201 aa)
	I79_024287	Patched domain-containing protein 2. (1247 aa)
	I79_024341	Paired mesoderm homeobox protein 2B. (182 aa)
	Apbb1	Amyloid beta A4 protein-binding family B member 1. (530 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Apbb1	App	G3IMH5	G3HMG4	Amyloid beta A4 protein-binding family B member 1.	Amyloid beta A4 protein.	0.996
Apbb1	I79_012607	G3IMH5	G3HP98	Amyloid beta A4 protein-binding family B member 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.442
App	Apbb1	G3HMG4	G3IMH5	Amyloid beta A4 protein.	Amyloid beta A4 protein-binding family B member 1.	0.996
App	Calr	G3HMG4	G3HCX8	Amyloid beta A4 protein.	Calreticulin.	0.521
App	Cntn2	G3HMG4	G3HAW9	Amyloid beta A4 protein.	Contactin-2.	0.757
App	Gsk3b	G3HMG4	G3HAI0	Amyloid beta A4 protein.	Glycogen synthase kinase-3 beta.	0.560
App	I79_004643	G3HMG4	G3H335	Amyloid beta A4 protein.	Contactin-4.	0.823
App	I79_006225	G3HMG4	G3H796	Amyloid beta A4 protein.	Sonic hedgehog protein.	0.471
App	I79_012168	G3HMG4	G3HN37	Amyloid beta A4 protein.	Fragile X mental retardation 1 protein.	0.454
App	IL1B	G3HMG4	G3I1B0	Amyloid beta A4 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.487
App	Itgb1	G3HMG4	G3HZ55	Amyloid beta A4 protein.	Integrin beta; Belongs to the integrin beta chain family.	0.567
Ascl1	Dll1	G3H670	G3HNT7	Achaete-scute-like 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.401
Ascl1	Dlx1	G3H670	G3GUB6	Achaete-scute-like 1.	Homeobox protein DLX-1.	0.501
Ascl1	Dlx2	G3H670	G3GUB7	Achaete-scute-like 1.	Homeobox protein DLX-2.	0.583
Ascl1	I79_011789	G3H670	G3HM41	Achaete-scute-like 1.	DNA-binding protein inhibitor ID-2.	0.426
Ascl1	I79_015503	G3H670	G3HWY8	Achaete-scute-like 1.	Transcription factor HES-1.	0.596
Ascl1	Isl1	G3H670	G3H207	Achaete-scute-like 1.	Insulin gene enhancer protein ISL-1.	0.529
Ascl1	Isl2	G3H670	G3H0D0	Achaete-scute-like 1.	Insulin gene enhancer protein ISL-2.	0.461
Ascl1	Sox2	G3H670	G3HJZ4	Achaete-scute-like 1.	Transcription factor SOX-2.	0.490
Aspm	I79_011753	G3HM10	G3HM09	Abnormal spindle-like microcephaly-associated protein-like.	Abnormal spindle-like microcephaly-associated protein-like.	0.928