STRINGSTRING
Nfatc1 Nfatc1 Ddx5 Ddx5 Prkaca Prkaca Hoxa2 Hoxa2 Bmp6 Bmp6 Id1 Id1 Cd276 Cd276 Apc Apc Lmna Lmna Vegfc Vegfc I79_010073 I79_010073 Sfrp1 Sfrp1 Acvr1 Acvr1 Il6st Il6st Tmem119 Tmem119 H671_3g8622 H671_3g8622 Wnt4 Wnt4 Smad5 Smad5 Sox2 Sox2 Hdac5 Hdac5 I79_011789 I79_011789 Id3 Id3 I79_012296 I79_012296 Ddr2 Ddr2 Snai2 Snai2 Acvr2b Acvr2b I79_013535 I79_013535 I79_013621 I79_013621 Bambi Bambi Ltf Ltf Ahr Ahr Fam20c Fam20c I79_014724 I79_014724 Crim1 Crim1 Gli3 Gli3 PPARG PPARG I79_015033 I79_015033 I79_015109 I79_015109 Gli1 Gli1 Zhx3 Zhx3 Limd1 Limd1 Acvr2a Acvr2a Wwtr1 Wwtr1 Hdac4 Hdac4 Twsg1 Twsg1 Clic1 Clic1 Tnf Tnf Trpm4 Trpm4 Ski Ski Cebpd Cebpd H671_4g11668 H671_4g11668 I79_017864 I79_017864 Tcirg1 Tcirg1 Lrp5 Lrp5 I79_018885 I79_018885 Men1 Men1 Fermt2 Fermt2 Wnt10b Wnt10b Ptk2 Ptk2 Esrra Esrra Rest Rest I79_020064 I79_020064 Areg Areg Wnt7b Wnt7b Hdac8 Hdac8 Grem1 Grem1 Tnfaip6 Tnfaip6 I79_021938 I79_021938 Hdac7 Hdac7 Rorb Rorb I79_022080 I79_022080 I79_022235 I79_022235 I79_022515 I79_022515 Atf4 Atf4 I79_023475 I79_023475 Ptch1 Ptch1 Ctnnbip1 Ctnnbip1 I79_024611 I79_024611 I79_024959 I79_024959 Nppc Nppc I79_025316 I79_025316 I79_025459 I79_025459 I79_025513 I79_025513 I79_025542 I79_025542 I79_025549 I79_025549 I79_025783 I79_025783 I79_025994 I79_025994 Mef2c Mef2c Noct Noct Gsk3b Gsk3b Smad1 Smad1 I79_006981 I79_006981 Ctnnb1 Ctnnb1 Smad3 Smad3 Smad6 Smad6 I79_006745 I79_006745 Axin2 Axin2 Hemgn Hemgn I79_006254 I79_006254 Tent5a Tent5a Fndc3b Fndc3b Igf1 Igf1 I79_005573 I79_005573 I79_005202 I79_005202 I79_005201 I79_005201 Igfbp5 Igfbp5 Smoc1 Smoc1 I79_004044 I79_004044 I79_004031 I79_004031 Nog Nog Msx2 Msx2 Pdlim7 Pdlim7 Tnn Tnn Suco Suco Bmpr2 Bmpr2 Cdk6 Cdk6 I79_002219 I79_002219 I79_001484 I79_001484 Fgf23 Fgf23 I79_000973 I79_000973 Tp63 Tp63 Ostn Ostn Jag1 Jag1 ilk ilk Tob1 Tob1 Bmp7 Bmp7 Dlx5 Dlx5 Runx2 Runx2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (203 aa)
Ddx5Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (615 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
Hoxa2Homeobox protein Hox-A2. (76 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
Id1DNA-binding protein inhibitor ID-1. (157 aa)
Cd276CD276 antigen. (316 aa)
ApcAdenomatous polyposis coli protein. (2488 aa)
LmnaLamin-A/C; Belongs to the intermediate filament family. (563 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
I79_010073Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Acvr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
Tmem119Transmembrane protein 119. (277 aa)
H671_3g8622Semaphorin-4D; Belongs to the semaphorin family. (833 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
Smad5Mothers against decapentaplegic homolog. (462 aa)
Sox2Transcription factor SOX-2. (273 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
Id3DNA-binding protein inhibitor ID-3. (119 aa)
I79_012296Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (320 aa)
Ddr2Discoidin domain-containing receptor 2. (854 aa)
Snai2Zinc finger protein SNAI2-like protein. (268 aa)
Acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (559 aa)
I79_013535Fibrillin-3. (1889 aa)
I79_013621Signal peptide, CUB and EGF-like domain-containing protein 3. (855 aa)
BambiBMP and activin membrane-bound inhibitor-like. (218 aa)
LtfLactotransferrin; Belongs to the transferrin family. (648 aa)
AhrAryl hydrocarbon receptor. (247 aa)
Fam20cDentin matrix protein 4. (776 aa)
I79_014724Cysteine-rich motor neuron 1 protein. (344 aa)
Crim1Cysteine-rich motor neuron 1 protein. (556 aa)
Gli3Zinc finger protein GLI3. (1582 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_015033Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
I79_015109Interleukin-6. (174 aa)
Gli1Zinc finger protein GLI1. (1104 aa)
Zhx3Zinc fingers and homeoboxes protein 3. (987 aa)
Limd1LIM domain-containing protein 1. (667 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
Wwtr1WW domain-containing transcription regulator protein 1. (395 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
Twsg1Twisted gastrulation protein-like 1. (222 aa)
Clic1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Trpm4Transient receptor potential cation channel subfamily M member 4. (315 aa)
SkiSki oncogene. (636 aa)
CebpdCCAAT/enhancer-binding protein. (268 aa)
H671_4g11668Chordin. (842 aa)
I79_017864Fibrillin-2. (2601 aa)
Tcirg1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (835 aa)
Lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
I79_018885Transmembrane protein 64. (105 aa)
Men1Menin. (610 aa)
Fermt2Fermitin family-like 2. (575 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
EsrraSteroid hormone receptor ERR1. (548 aa)
RestRE1-silencing transcription factor. (1047 aa)
I79_020064Low-density lipoprotein receptor-related protein 3. (767 aa)
AregAmphiregulin. (230 aa)
Wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
Hdac8Histone deacetylase 8. (257 aa)
Grem1Gremlin-1. (117 aa)
Tnfaip6Tumor necrosis factor-inducible gene 6 protein. (275 aa)
I79_021938Mothers against decapentaplegic-like 1. (122 aa)
Hdac7Histone deacetylase 7. (424 aa)
RorbNuclear receptor ROR-beta. (440 aa)
I79_022080Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (402 aa)
I79_022235WD repeat-containing protein 63. (748 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
Ptch1Protein patched-like 1. (1114 aa)
Ctnnbip1Beta-catenin-interacting protein 1. (81 aa)
I79_024611Signal peptide, CUB and EGF-like domain-containing protein 2. (583 aa)
I79_024959Mothers against decapentaplegic-like 1. (161 aa)
NppcC-type natriuretic peptide. (126 aa)
I79_025316Mothers against decapentaplegic-like 1. (104 aa)
I79_025459Mothers against decapentaplegic-like 1. (117 aa)
I79_025513Mothers against decapentaplegic-like 1. (151 aa)
I79_025542WD repeat-containing protein 63. (181 aa)
I79_025549WNT1-inducible-signaling pathway protein 1. (274 aa)
I79_025783Mothers against decapentaplegic-like 1. (97 aa)
I79_025994WNT1-inducible-signaling pathway protein 1. (136 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
NoctNocturnin. (365 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Smad1Mothers against decapentaplegic-like 1. (232 aa)
I79_006981G-protein coupled receptor 120. (318 aa)
Ctnnb1Catenin beta-1. (781 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Smad6Mothers against decapentaplegic-like 6. (174 aa)
I79_006745Mothers against decapentaplegic-like 6. (71 aa)
Axin2Axin-2. (809 aa)
HemgnHemogen. (86 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Tent5aProtein FAM46A. (428 aa)
Fndc3bFibronectin type III domain-containing protein 3B. (1203 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
I79_005202Serine/threonine-protein kinase D1. (748 aa)
I79_005201Serine/threonine-protein kinase D1. (116 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
Smoc1SPARC-related modular calcium-binding protein 1. (93 aa)
I79_004044SPARC-related modular calcium-binding protein 1. (272 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
NogNoggin. (117 aa)
Msx2Homeobox protein MSX-2. (267 aa)
Pdlim7PDZ and LIM domain protein 7. (366 aa)
TnnTenascin-N. (1552 aa)
SucoProtein C1orf9-like. (1150 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Cdk6Cell division protein kinase 6. (273 aa)
I79_002219Neuroendocrine secretory protein 55. (295 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
I79_000973Transcription factor SOX-10. (360 aa)
Tp63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
OstnOsteocrin. (105 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
ilkIntegrin-linked protein kinase. (452 aa)
Tob1Protein Tob1-like protein. (350 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Dlx5Homeobox protein DLX-5. (289 aa)
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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