(48 nodes) Negative regulation of osteoblast differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Crim1	Cysteine-rich motor neuron 1 protein. (556 aa)
	Ostn	Osteocrin. (105 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Fgf23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	Cdk6	Cell division protein kinase 6. (273 aa)
	Tnn	Tenascin-N. (1552 aa)
	Nog	Noggin. (117 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)
	Igfbp5	Insulin-like growth factor-binding protein 5. (271 aa)
	Fndc3b	Fibronectin type III domain-containing protein 3B. (1203 aa)
	Axin2	Axin-2. (809 aa)
	I79_006745	Mothers against decapentaplegic-like 6. (71 aa)
	Smad6	Mothers against decapentaplegic-like 6. (174 aa)
	Smad3	Mothers against decapentaplegic homolog. (363 aa)
	Noct	Nocturnin. (365 aa)
	Tob1	Protein Tob1-like protein. (350 aa)
	Nfatc1	Nuclear factor of activated T-cells, cytoplasmic 1. (203 aa)
	Hoxa2	Homeobox protein Hox-A2. (76 aa)
	Id1	DNA-binding protein inhibitor ID-1. (157 aa)
	Vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	H671_3g8622	Semaphorin-4D; Belongs to the semaphorin family. (833 aa)
	Sox2	Transcription factor SOX-2. (273 aa)
	Hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
	I79_011789	DNA-binding protein inhibitor ID-2. (185 aa)
	Id3	DNA-binding protein inhibitor ID-3. (119 aa)
	I79_012296	Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (320 aa)
	Bambi	BMP and activin membrane-bound inhibitor-like. (218 aa)
	Ahr	Aryl hydrocarbon receptor. (247 aa)
	I79_014724	Cysteine-rich motor neuron 1 protein. (344 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Limd1	LIM domain-containing protein 1. (667 aa)
	Hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
	Twsg1	Twisted gastrulation protein-like 1. (222 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Trpm4	Transient receptor potential cation channel subfamily M member 4. (315 aa)
	Ski	Ski oncogene. (636 aa)
	H671_4g11668	Chordin. (842 aa)
	Lrp5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
	I79_018885	Transmembrane protein 64. (105 aa)
	Men1	Menin. (610 aa)
	Areg	Amphiregulin. (230 aa)
	Hdac8	Histone deacetylase 8. (257 aa)
	Grem1	Gremlin-1. (117 aa)
	Tnfaip6	Tumor necrosis factor-inducible gene 6 protein. (275 aa)
	Hdac7	Histone deacetylase 7. (424 aa)
	Rorb	Nuclear receptor ROR-beta. (440 aa)
	Ptch1	Protein patched-like 1. (1114 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Areg	Tnfaip6	G3IBU4	G3IDR6	Amphiregulin.	Tumor necrosis factor-inducible gene 6 protein.	0.552
Axin2	Lrp5	G3H862	G3I5B4	Axin-2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.819
Axin2	Sfrp1	G3H862	G3HHI7	Axin-2.	Secreted frizzled-related protein 1.	0.529
Bambi	H671_4g11668	G3HT30	G3I302	BMP and activin membrane-bound inhibitor-like.	Chordin.	0.423
Bambi	I79_006745	G3HT30	G3H8N7	BMP and activin membrane-bound inhibitor-like.	Mothers against decapentaplegic-like 6.	0.650
Bambi	Lrp5	G3HT30	G3I5B4	BMP and activin membrane-bound inhibitor-like.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.911
Bambi	Smad3	G3HT30	G3H8N9	BMP and activin membrane-bound inhibitor-like.	Mothers against decapentaplegic homolog.	0.524
Bambi	Smad6	G3HT30	G3H8N8	BMP and activin membrane-bound inhibitor-like.	Mothers against decapentaplegic-like 6.	0.746
Crim1	I79_014724	G3HUV7	G3HUV6	Cysteine-rich motor neuron 1 protein.	Cysteine-rich motor neuron 1 protein.	0.920
Fgf23	I79_004031	G3GUK1	G3H1K2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.975
Grem1	H671_4g11668	G3ID48	G3I302	Gremlin-1.	Chordin.	0.410
Grem1	Nog	G3ID48	G3H1C7	Gremlin-1.	Noggin.	0.479
H671_4g11668	Bambi	G3I302	G3HT30	Chordin.	BMP and activin membrane-bound inhibitor-like.	0.423
H671_4g11668	Grem1	G3I302	G3ID48	Chordin.	Gremlin-1.	0.410
H671_4g11668	Nog	G3I302	G3H1C7	Chordin.	Noggin.	0.573
H671_4g11668	Sfrp1	G3I302	G3HHI7	Chordin.	Secreted frizzled-related protein 1.	0.459
H671_4g11668	Smad6	G3I302	G3H8N8	Chordin.	Mothers against decapentaplegic-like 6.	0.557
H671_4g11668	Tnfaip6	G3I302	G3IDR6	Chordin.	Tumor necrosis factor-inducible gene 6 protein.	0.688
H671_4g11668	Twsg1	G3I302	G3HZ28	Chordin.	Twisted gastrulation protein-like 1.	0.733
Hdac4	Hdac5	G3HYN8	G3HLJ3	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.955