STRINGSTRING
I79_025745 I79_025745 Serpine2 Serpine2 Il34 Il34 LDLR LDLR Egr2 Egr2 I79_007340 I79_007340 I79_007329 I79_007329 Nr1d1 Nr1d1 Il33 Il33 I79_018306 I79_018306 Clcf1 Clcf1 Acy3 Acy3 I79_017935 I79_017935 IL1B IL1B Lif Lif Dicer1 Dicer1 I79_015503 I79_015503 I79_015046 I79_015046 PPARG PPARG Tnfrsf21 Tnfrsf21 Mecp2 Mecp2 Prmt5 Prmt5 I79_018913 I79_018913 I79_019031 I79_019031 Atf5 Atf5 Tgfb1 Tgfb1 I79_020615 I79_020615 I79_020783 I79_020783 H671_1g3307 H671_1g3307 Spint1 Spint1 I79_021789 I79_021789 Rela Rela I79_021945 I79_021945 Mtor Mtor I79_013088 I79_013088 Ptprz1 Ptprz1 I79_011789 I79_011789 Bin1 Bin1 Dusp10 Dusp10 I79_000801 I79_000801 I79_001046 I79_001046 Tmem98 Tmem98 Dlx1 Dlx1 Dlx2 Dlx2 Ntf3 Ntf3 I79_001731 I79_001731 I79_002496 I79_002496 I79_002659 I79_002659 Mdk Mdk F2 F2 Actr3 Actr3 Cxcr4 Cxcr4 I79_003549 I79_003549 Nog Nog Gpr37l1 Gpr37l1 Ptpra Ptpra Fgfr3 Fgfr3 Rtn4 Rtn4 I79_010923 I79_010923 I79_010785 I79_010785 Sirt2 Sirt2 Znf365 Znf365 I79_006225 I79_006225 I79_006254 I79_006254 Il6st Il6st Hdac2 Hdac2 I79_009343 I79_009343 Kdm4a Kdm4a Dusp15 Dusp15 Dag1 Dag1 Hdac1 Hdac1 I79_006923 I79_006923 I79_006924 I79_006924 Ctnnb1 Ctnnb1 Ptn Ptn I79_007328 I79_007328 I79_022486 I79_022486 Cntn2 Cntn2 I79_023241 I79_023241 Ntrk3 Ntrk3 Tcf7l2 Tcf7l2 I79_024271 I79_024271 Tnfrsf1b Tnfrsf1b Rheb Rheb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_025745Nuclear receptor subfamily 1 group D member 1. (226 aa)
Serpine2Glia-derived nexin; Belongs to the serpin family. (189 aa)
Il34Interleukin-34. (201 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
Egr2Early growth response protein 2. (410 aa)
I79_007340Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (592 aa)
I79_007329Histone deacetylase 1. (250 aa)
Nr1d1Nuclear receptor subfamily 1 group D member 1. (508 aa)
Il33Interleukin-33. (217 aa)
I79_018306Ephrin type-A receptor 4. (932 aa)
Clcf1Cardiotrophin-like cytokine factor 1. (225 aa)
Acy3Aspartoacylase-2. (319 aa)
I79_017935Lin-28-like A. (169 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
Dicer1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
I79_015503Transcription factor HES-1. (92 aa)
I79_015046Low-density lipoprotein receptor. (160 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Tnfrsf21Tumor necrosis factor receptor superfamily member 21. (654 aa)
Mecp2Methyl-CpG-binding protein 2. (203 aa)
Prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (577 aa)
I79_018913Homeobox protein Nkx-6.2. (114 aa)
I79_019031Teneurin-4. (3477 aa)
Atf5Cyclic AMP-dependent transcription factor ATF-5. (279 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
I79_020615BAG family molecular chaperone regulator 1. (125 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
H671_1g3307Disheveled-associated activator of morphogenesis 2. (967 aa)
Spint1Kunitz-type protease inhibitor 1. (499 aa)
I79_021789NT-3 growth factor receptor. (389 aa)
RelaTranscription factor p65. (546 aa)
I79_021945Pre-mRNA-processing factor 19. (487 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_013088Methyl-CpG-binding domain protein 1. (330 aa)
Ptprz1Receptor-type tyrosine-protein phosphatase zeta. (2289 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
Bin1Myc box-dependent-interacting protein 1. (522 aa)
Dusp10Dual specificity protein phosphatase 10. (482 aa)
I79_000801Histone deacetylase 1. (92 aa)
I79_001046Neurofibromin. (2164 aa)
Tmem98Transmembrane protein 98. (226 aa)
Dlx1Homeobox protein DLX-1. (255 aa)
Dlx2Homeobox protein DLX-2. (347 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
I79_001731RING finger protein 112. (443 aa)
I79_002496Nuclear receptor subfamily 2 group E member 1. (323 aa)
I79_002659High mobility group protein HMGI-C. (103 aa)
MdkMidkine. (160 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
Actr3Actin-related protein 3; Belongs to the actin family. (418 aa)
Cxcr4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
I79_003549D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
NogNoggin. (117 aa)
Gpr37l1Endothelin B receptor-like protein 2. (481 aa)
PtpraReceptor-type tyrosine-protein phosphatase alpha. (1074 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
Rtn4Reticulon-4. (806 aa)
I79_010923Reticulon. (68 aa)
I79_010785Delta-like protein 3. (388 aa)
Sirt2NAD-dependent deacetylase sirtuin-2. (83 aa)
Znf365Protein ZNF365. (313 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
I79_009343N-myc proto-oncogene protein. (316 aa)
Kdm4aLysine-specific demethylase 4A. (576 aa)
Dusp15Dual specificity protein phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (307 aa)
Dag1Dystroglycan. (893 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
I79_006923Histone deacetylase 1. (235 aa)
I79_006924Histone deacetylase 1. (188 aa)
Ctnnb1Catenin beta-1. (781 aa)
PtnPleiotrophin. (168 aa)
I79_007328Histone deacetylase 2. (91 aa)
I79_022486GS homeobox 2. (100 aa)
Cntn2Contactin-2. (1008 aa)
I79_023241Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (558 aa)
Ntrk3Tyrosine-protein kinase receptor. (226 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
I79_024271NT-3 growth factor receptor. (114 aa)
Tnfrsf1bTumor necrosis factor receptor superfamily member 1B. (477 aa)
RhebGTP-binding protein Rheb. (179 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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