(38 nodes) Positive regulation of Notch signaling pathway network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	Enho	Adropin. (76 aa)
	Kit	Mast/stem cell growth factor receptor. (452 aa)
	Mfng	Beta-1,3-N-acetylglucosaminyltransferase manic fringe. (324 aa)
	Itgb1bp1	Integrin beta-1-binding protein 1. (199 aa)
	I79_022486	GS homeobox 2. (100 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	I79_017261	KTEL motif-containing protein 1. (333 aa)
	Bmp2k	BMP-2-inducible protein kinase. (1009 aa)
	I79_015746	AP2-associated protein kinase 1. (1206 aa)
	Fkbp14	Peptidylprolyl isomerase. (211 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	I79_014675	Contactin-6. (262 aa)
	Pdcd10	Programmed cell death protein 10. (210 aa)
	Tspan14	Tetraspanin. (270 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	I79_012060	Roundabout-like 2. (1397 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Sox2	Transcription factor SOX-2. (273 aa)
	Il6st	Interleukin-6 receptor subunit beta. (914 aa)
	I79_010159	Roundabout-like 1. (1362 aa)
	Robo1	Roundabout-like 1. (129 aa)
	I79_010003	Zinc finger MIZ domain-containing protein 1. (960 aa)
	Gata5	Transcription factor GATA-5. (406 aa)
	I79_007339	Protein NOV-like. (256 aa)
	Ascl1	Achaete-scute-like 1. (140 aa)
	Nod2	Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
	I79_004721	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1234 aa)
	Tm2d2	TM2 domain-containing protein 2. (213 aa)
	Nepro	Uncharacterized protein C3orf17. (492 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Rfng	Beta-1,3-N-acetylglucosaminyltransferase radical fringe. (229 aa)
	Lfng	Beta-1,3-N-acetylglucosaminyltransferase. (378 aa)
	I79_001484	65 kDa Yes-associated protein. (257 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Slc35c2	Solute carrier family 35 member C2. (358 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ascl1	Dll1	G3H670	G3HNT7	Achaete-scute-like 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.401
Ascl1	I79_015503	G3H670	G3HWY8	Achaete-scute-like 1.	Transcription factor HES-1.	0.596
Ascl1	Sox2	G3H670	G3HJZ4	Achaete-scute-like 1.	Transcription factor SOX-2.	0.490
Dll1	Ascl1	G3HNT7	G3H670	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Achaete-scute-like 1.	0.401
Dll1	Dll4	G3HNT7	G3ICK3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll1	I79_015503	G3HNT7	G3HWY8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.469
Dll1	Jag1	G3HNT7	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Dll1	Lfng	G3HNT7	G3GVF0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.714
Dll1	Mfng	G3HNT7	G3IJX8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase manic fringe.	0.589
Dll1	Rfng	G3HNT7	G3GXD4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase radical fringe.	0.652
Dll4	Dll1	G3ICK3	G3HNT7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll4	I79_004721	G3ICK3	G3H3A6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
Dll4	I79_015503	G3ICK3	G3HWY8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.596
Dll4	Jag1	G3ICK3	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.503
Dll4	Lfng	G3ICK3	G3GVF0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.543
Dll4	Mfng	G3ICK3	G3IJX8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase manic fringe.	0.537
Dll4	Rfng	G3ICK3	G3GXD4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase radical fringe.	0.517
I79_001484	Sox2	G3GUW0	G3HJZ4	65 kDa Yes-associated protein.	Transcription factor SOX-2.	0.407
I79_001484	Src	G3GUW0	G3GXX7	65 kDa Yes-associated protein.	Tyrosine-protein kinase.	0.654
I79_001484	Stat3	G3GUW0	G3HLW9	65 kDa Yes-associated protein.	Signal transducer and activator of transcription.	0.496