STRINGSTRING
S100a1 S100a1 Jmjd8 Jmjd8 Angpt2 Angpt2 I79_007744 I79_007744 I79_007738 I79_007738 I79_007693 I79_007693 Il10 Il10 Sirt1 Sirt1 I79_007297 I79_007297 Serpine1 Serpine1 I79_007264 I79_007264 Smad1 Smad1 Itgb2 Itgb2 Mmp9 Mmp9 Cd40 Cd40 Ets1 Ets1 Sema5a Sema5a Lgals3 Lgals3 I79_006225 I79_006225 Erap1 Erap1 Angpt4 Angpt4 Nodal Nodal Ghsr Ghsr Cdh5 Cdh5 I79_005573 I79_005573 Tjp1 Tjp1 I79_005202 I79_005202 I79_005201 I79_005201 I79_004922 I79_004922 I79_010061 I79_010061 Adam12 Adam12 Ninj1 Ninj1 Cxcr3 Cxcr3 I79_022645 I79_022645 Hk2 Hk2 I79_023183 I79_023183 Rras Rras Ddah1 Ddah1 I79_023328 I79_023328 Tlr3 Tlr3 I79_023874 I79_023874 I79_024415 I79_024415 I79_024959 I79_024959 Cxcr2 Cxcr2 I79_025316 I79_025316 I79_025454 I79_025454 I79_025459 I79_025459 I79_025512 I79_025512 I79_025513 I79_025513 I79_025783 I79_025783 I79_025933 I79_025933 Tert Tert H671_2g5523 H671_2g5523 I79_022034 I79_022034 I79_022056 I79_022056 Hgf Hgf Cx3cr1 Cx3cr1 Cysltr2 Cysltr2 Aplnr Aplnr I79_013817 I79_013817 Tbxa2r Tbxa2r I79_013999 I79_013999 Sphk1 Sphk1 Ccbe1 Ccbe1 Sp1 Sp1 Plcg1 Plcg1 Ccr3 Ccr3 I79_015916 I79_015916 Akt3 Akt3 Jak1 Jak1 I79_016007 I79_016007 I79_016125 I79_016125 Adm Adm Hif1a Hif1a Itgb1 Itgb1 Nrp1 Nrp1 I79_016362 I79_016362 Gpsm3 Gpsm3 Fut2 Fut2 I79_016879 I79_016879 IL1B IL1B I79_017273 I79_017273 Kctd5 Kctd5 Stim1 Stim1 C3ar1 C3ar1 Emc10 Emc10 I79_018849 I79_018849 Itga5 Itga5 Wars2 Wars2 I79_019127 I79_019127 I79_019428 I79_019428 AGO2 AGO2 Pik3cd Pik3cd Vegfb Vegfb Ccl5 Ccl5 Prkcb Prkcb I79_020424 I79_020424 I79_020442 I79_020442 Klf4 Klf4 Hmox1 Hmox1 I79_020755 I79_020755 I79_020968 I79_020968 I79_020969 I79_020969 I79_021045 I79_021045 Acvrl1 Acvrl1 Grem1 Grem1 Cd34 Cd34 I79_021938 I79_021938 Pkm Pkm Chi3l1 Chi3l1 I79_004631 I79_004631 Ecm1 Ecm1 Isl1 Isl1 Nfe2l2 Nfe2l2 Cxcr4 Cxcr4 Tnn Tnn Pdcd6 Pdcd6 Mdk Mdk I79_002696 I79_002696 I79_002659 I79_002659 Emilin1 Emilin1 I79_002496 I79_002496 Uts2r Uts2r Ghrl Ghrl I79_002157 I79_002157 Emp2 Emp2 I79_002099 I79_002099 Tgfbr2 Tgfbr2 Wnt5a Wnt5a Tnfrsf1a Tnfrsf1a I79_001232 I79_001232 Pxn Pxn I79_001073 I79_001073 Xbp1 Xbp1 Runx1 Runx1 Dll1 Dll1 I79_012336 I79_012336 Jcad Jcad Brca1 Brca1 Stat3 Stat3 Jup Jup Grn Grn I79_011419 I79_011419 Camp Camp Mtdh Mtdh Smoc2 Smoc2 Rtn4 Rtn4 I79_010923 I79_010923 Aqp1 Aqp1 Btg1 Btg1 Pak4 Pak4 Gata2 Gata2 I79_010224 I79_010224 Thbs1 Thbs1 I79_010163 I79_010163 Pdcl3 Pdcl3 I79_009992 I79_009992 I79_009958 I79_009958 Vegfc Vegfc Itgb3 Itgb3 Pgf Pgf I79_009314 I79_009314 Ptgis Ptgis Fgf1 Fgf1 Zc3h12a Zc3h12a Rhob Rhob Prkca Prkca C3 C3 Mydgf Mydgf I79_008174 I79_008174 I79_008095 I79_008095
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
S100a1Protein S100; Belongs to the S-100 family. (94 aa)
Jmjd8JmjC domain-containing protein 8. (291 aa)
Angpt2Angiopoietin-2. (288 aa)
I79_007744Angiopoietin-2. (188 aa)
I79_007738Pyruvate kinase isozymes M1/M2. (120 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
Il10Interleukin-10. (178 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
I79_007297Plasminogen activator inhibitor 1; Belongs to the serpin family. (108 aa)
Serpine1Plasminogen activator inhibitor 1; Belongs to the serpin family. (270 aa)
I79_007264Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (84 aa)
Smad1Mothers against decapentaplegic-like 1. (232 aa)
Itgb2Integrin beta. (769 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
Ets1Protein C-ets-1. (257 aa)
Sema5aSemaphorin-5A. (1046 aa)
Lgals3Galectin. (281 aa)
I79_006225Sonic hedgehog protein. (226 aa)
Erap1Aminopeptidase. (941 aa)
Angpt4Angiopoietin-4. (499 aa)
NodalNodal. (309 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
Cdh5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (763 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
Tjp1Tight junction protein ZO-1. (762 aa)
I79_005202Serine/threonine-protein kinase D1. (748 aa)
I79_005201Serine/threonine-protein kinase D1. (116 aa)
I79_004922SAM and SH3 domain-containing protein 1. (999 aa)
I79_010061Complement component C6. (550 aa)
Adam12Disintegrin and metalloproteinase domain-containing protein 12. (244 aa)
Ninj1Ninjurin-1. (102 aa)
Cxcr3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (286 aa)
I79_022645Programmed cell death protein 6. (224 aa)
Hk2Hexokinase-2. (704 aa)
I79_023183Zinc finger protein 304. (368 aa)
RrasRas-related protein R-Ras. (126 aa)
Ddah1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1. (177 aa)
I79_023328Complement C5. (498 aa)
Tlr3Toll-like receptor 3. (164 aa)
I79_023874Pyruvate kinase; Belongs to the pyruvate kinase family. (233 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
I79_024959Mothers against decapentaplegic-like 1. (161 aa)
Cxcr2High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)
I79_025316Mothers against decapentaplegic-like 1. (104 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
I79_025459Mothers against decapentaplegic-like 1. (117 aa)
I79_025512Urotensin-2. (88 aa)
I79_025513Mothers against decapentaplegic-like 1. (151 aa)
I79_025783Mothers against decapentaplegic-like 1. (97 aa)
I79_025933Programmed cell death protein 6. (60 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
H671_2g5523Rap guanine nucleotide exchange factor 3-like protein. (979 aa)
I79_022034Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
I79_022056Annexin. (319 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
Cx3cr1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
Cysltr2Cysteinyl leukotriene receptor 2. (322 aa)
AplnrApelin receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
I79_013817NAD-dependent deacetylase sirtuin-6. (334 aa)
Tbxa2rThromboxane A2 receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (339 aa)
I79_013999Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (328 aa)
Sphk1Sphingosine kinase 1. (383 aa)
Ccbe1Collagen and calcium-binding EGF domain-containing protein 1. (303 aa)
Sp1Transcription factor Sp1. (778 aa)
Plcg1Phosphoinositide phospholipase C. (1217 aa)
Ccr3Putative C-C chemokine receptor type 3-like protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Jak1Tyrosine-protein kinase. (1140 aa)
I79_016007Cytochrome b-245 heavy chain. (396 aa)
I79_016125Pyruvate kinase isozymes M1/M2. (110 aa)
AdmProcalcitonin/adrenomedullin containing protein. (184 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
Itgb1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (923 aa)
I79_016362Vasohibin-2. (477 aa)
Gpsm3Neurogenic locus notch-like protein 4. (1797 aa)
Fut2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (646 aa)
I79_016879Alpha-adducin. (735 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_017273Protein kinase C alpha type. (128 aa)
Kctd53-phosphoinositide-dependent protein kinase 1; Belongs to the peptidase S1 family. (799 aa)
Stim1Stromal interaction molecule 1. (716 aa)
C3ar1C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
Emc10UPF0510 protein INM02. (222 aa)
I79_018849Serine/threonine-protein kinase D2. (513 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (729 aa)
Wars2Tryptophanyl-tRNA synthetase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
I79_019127Integrin beta; Belongs to the integrin beta chain family. (435 aa)
I79_019428Integrin alpha-X; Belongs to the integrin alpha chain family. (1016 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (813 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
VegfbVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
Ccl5C-C motif chemokine. (91 aa)
PrkcbNon-specific serine/threonine protein kinase. (544 aa)
I79_020424Pyruvate kinase; Belongs to the pyruvate kinase family. (258 aa)
I79_020442Heparanase. (563 aa)
Klf4Krueppel-like factor 4. (474 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
I79_020755Pyruvate kinase; Belongs to the pyruvate kinase family. (461 aa)
I79_020968Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
I79_020969Fibroblast growth factor 18. (85 aa)
I79_021045Heme oxygenase 1. (81 aa)
Acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (776 aa)
Grem1Gremlin-1. (117 aa)
Cd34Hematopoietic progenitor cell antigen CD34. (383 aa)
I79_021938Mothers against decapentaplegic-like 1. (122 aa)
PkmPyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
Chi3l1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (719 aa)
I79_004631Angiogenic factor with G patch and FHA domains 1. (667 aa)
Ecm1Extracellular matrix protein 1. (563 aa)
Isl1Insulin gene enhancer protein ISL-1. (257 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (588 aa)
Cxcr4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
TnnTenascin-N. (1552 aa)
Pdcd6Programmed cell death protein 6. (83 aa)
MdkMidkine. (160 aa)
I79_002696Phosphoinositide 3-kinase regulatory subunit 6. (395 aa)
I79_002659High mobility group protein HMGI-C. (103 aa)
Emilin1EMILIN-1. (1017 aa)
I79_002496Nuclear receptor subfamily 2 group E member 1. (323 aa)
Uts2rUrotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
GhrlAppetite-regulating hormone. (100 aa)
I79_002157Phosphotransferase. (266 aa)
Emp2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
I79_002099Vascular endothelial growth factor receptor 1. (115 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
Tnfrsf1aTumor necrosis factor receptor superfamily member 1A. (355 aa)
I79_001232Paxillin; Belongs to the phospholipase A2 family. (642 aa)
PxnPaxillin. (388 aa)
I79_001073C-C motif chemokine. (72 aa)
Xbp1X-box binding protein 1 isoform 1. (330 aa)
Runx1Runt-related transcription factor 1. (462 aa)
Dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
I79_012336Protein tyrosine kinase 2 beta. (53 aa)
JcadUncharacterized protein KIAA1462. (954 aa)
Brca1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
JupJunction plakoglobin. (1148 aa)
GrnGranulins. (592 aa)
I79_011419Ephrin type-A receptor 1. (887 aa)
CampCathelin-related antimicrobial peptide. (108 aa)
MtdhProtein LYRIC. (247 aa)
Smoc2SPARC-related modular calcium-binding protein 2. (457 aa)
Rtn4Reticulon-4. (806 aa)
I79_010923Reticulon. (68 aa)
Aqp1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
Btg1Protein BTG1. (97 aa)
Pak4Non-specific serine/threonine protein kinase. (588 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
I79_010224BMP-binding endothelial regulator protein. (371 aa)
Thbs1Thrombospondin-1. (533 aa)
I79_010163Zinc transporter ZIP12. (350 aa)
Pdcl3Phosducin-like protein 3. (241 aa)
I79_009992Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (259 aa)
I79_009958Angiopoietin-1 receptor. (793 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
PgfPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
I79_009314Tyrosine-protein kinase receptor Tie-1. (954 aa)
PtgisProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Zc3h12aRibonuclease ZC3H12A. (577 aa)
RhobRho-related GTP-binding protein RhoB. (196 aa)
PrkcaNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
C3Complement C3. (1626 aa)
MydgfUPF0556 protein C19orf10-like. (166 aa)
I79_008174Leucine-rich alpha-2-glycoprotein. (117 aa)
I79_008095Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (213 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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