(60 nodes) Negative regulation of blood pressure network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Adra1a	Alpha-1A adrenergic receptor. (465 aa)
	I79_000430	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (533 aa)
	I79_000677	Cannabinoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	I79_001488	Rho GTPase-activating protein 10-like. (439 aa)
	Abat	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
	Snx5	Sorting nexin-5. (289 aa)
	Drd5	D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (403 aa)
	I79_002219	Neuroendocrine secretory protein 55. (295 aa)
	Uts2r	Urotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	Ucn	Urocortin. (122 aa)
	Bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	I79_003549	D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	Scpep1	Carboxypeptidase; Belongs to the peptidase S10 family. (455 aa)
	Ptafr	Platelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	Drd2	D(2) dopamine receptor. (274 aa)
	I79_004403	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (187 aa)
	Npy	Neuropeptide Y. (148 aa)
	Gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	Gpr37l1	Endothelin B receptor-like protein 2. (481 aa)
	Rnpep	Aminopeptidase B. (650 aa)
	Adora1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	Adra1d	Alpha-1D adrenergic receptor. (485 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Pmch	Pro-MCH. (151 aa)
	Gch1	GTP cyclohydrolase 1. (248 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	I79_008252	Guanylate cyclase activator 2B. (104 aa)
	I79_008980	Bardet-Biedl syndrome 4 protein-like. (104 aa)
	Bbs4	Bardet-Biedl syndrome 4 protein-like. (125 aa)
	Vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
	Hrh3	Histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	Ahr	Aryl hydrocarbon receptor. (247 aa)
	I79_013771	Calcitonin. (206 aa)
	Sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
	Adipoq	Adiponectin. (248 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Smtn	Smoothelin. (70 aa)
	I79_017432	Smoothelin. (918 aa)
	Agtr2	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	CgPICR_008653	Lysosomal Pro-X carboxypeptidase. (492 aa)
	I79_020342	Renalase. (139 aa)
	Oprl1	Nociceptin receptor; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	I79_022034	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
	I79_013769	E3 ubiquitin-protein ligase NEDD4-like. (182 aa)
	Ier3	Radiation-inducible immediate-early gene IEX-1. (160 aa)
	Kl	Klotho. (900 aa)
	Glp1r	Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (437 aa)
	Tac4	Tachykinin-4. (127 aa)
	Bdkrb1	B1 bradykinin receptor. (332 aa)
	Bdkrb2	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	I79_009907	ATP-binding cassette transporter sub-family C member 9. (1368 aa)
	Ntsr1	Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	Guca2b	Guanylate cyclase activator 2B. (107 aa)
	I79_025512	Urotensin-2. (88 aa)
	Nppa	Atrial natriuretic factor. (362 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)
	I79_022390	Peroxisome proliferator-activated receptor alpha. (110 aa)
	Adrb2	Beta-2 adrenergic receptor. (337 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	I79_022390	G3HYG0	G3IF74	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.649
Adipoq	Npy	G3HYG0	G3H2L2	Adiponectin.	Neuropeptide Y.	0.493
Adipoq	Ppara	G3HYG0	G3IF76	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.677
Adipoq	Tnf	G3HYG0	G3HZG9	Adiponectin.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.556
Adora1	Bdkrb2	G3H3K9	G3HHC7	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family.	0.900
Adora1	Npy	G3H3K9	G3H2L2	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Neuropeptide Y.	0.710
Adra1a	Adra1d	G3HNK2	G3H417	Alpha-1A adrenergic receptor.	Alpha-1D adrenergic receptor.	0.937
Adra1d	Adra1a	G3H417	G3HNK2	Alpha-1D adrenergic receptor.	Alpha-1A adrenergic receptor.	0.937
Adrb2	Npy	G3IEF8	G3H2L2	Beta-2 adrenergic receptor.	Neuropeptide Y.	0.779
Agtr2	Bdkrb2	G3I4R1	G3HHC7	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family.	0.485
Agtr2	Npy	G3I4R1	G3H2L2	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Neuropeptide Y.	0.400
Agtr2	Pmch	G3I4R1	G3H674	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Pro-MCH.	0.421
Bbs4	I79_008980	G3HEJ7	G3HEJ6	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.450
Bdkrb1	Bdkrb2	G3HHC9	G3HHC7	B1 bradykinin receptor.	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family.	0.966
Bdkrb1	Gpr37l1	G3HHC9	G3H3H7	B1 bradykinin receptor.	Endothelin B receptor-like protein 2.	0.437
Bdkrb2	Adora1	G3HHC7	G3H3K9	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.900
Bdkrb2	Agtr2	G3HHC7	G3I4R1	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family.	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	0.485
Bdkrb2	Bdkrb1	G3HHC7	G3HHC9	B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family.	B1 bradykinin receptor.	0.966
Bmpr2	Gpr37l1	G3GYU9	G3H3H7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endothelin B receptor-like protein 2.	0.478
Bmpr2	I79_013769	G3GYU9	G3HSD8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	E3 ubiquitin-protein ligase NEDD4-like.	0.405