STRINGSTRING
Runx2 Runx2 I79_000092 I79_000092 Wnt5a Wnt5a Pkdcc Pkdcc Asxl2 Asxl2 Bmpr2 Bmpr2 Tacr1 Tacr1 Thrb Thrb I79_004285 I79_004285 I79_004244 I79_004244 Tent5a Tent5a I79_006254 I79_006254 Smad3 Smad3 Fzd9 Fzd9 Ptn Ptn Mef2c Mef2c I79_007641 I79_007641 Lrp6 Lrp6 Bmp7 Bmp7 Bmp6 Bmp6 Osr1 Osr1 Cd276 Cd276 I79_009364 I79_009364 Tgfb3 Tgfb3 I79_010073 I79_010073 Acvr1 Acvr1 Tmem119 Tmem119 Wnt4 Wnt4 Nipbl Nipbl Fgfr3 Fgfr3 Atp2b1 Atp2b1 I79_011367 I79_011367 Adgrv1 Adgrv1 I79_011453 I79_011453 Kl Kl Acvr2b Acvr2b I79_013535 I79_013535 I79_014629 I79_014629 Fam20c Fam20c Acvr2a Acvr2a I79_016411 I79_016411 Pth Pth Zbtb16 Zbtb16 I79_017450 I79_017450 I79_017864 I79_017864 Isg15 Isg15 Actn3 Actn3 Wnt10b Wnt10b Tgfb1 Tgfb1 Alox5 Alox5 I79_022080 I79_022080 Adrb2 Adrb2 Tob2 Tob2 Ano6 Ano6 I79_024611 I79_024611 I79_025277 I79_025277 I79_025400 I79_025400
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
PkdccProtein kinase-like protein SgK493. (252 aa)
Asxl2Putative Polycomb group protein ASXL2. (1421 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ThrbThyroid hormone receptor beta. (377 aa)
I79_004285p2X purinoceptor 7. (805 aa)
I79_004244Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
Tent5aProtein FAM46A. (428 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Fzd9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (439 aa)
PtnPleiotrophin. (168 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
I79_007641Low-density lipoprotein receptor-related protein 6. (543 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (565 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
Osr1Protein odd-skipped-related 1. (266 aa)
Cd276CD276 antigen. (316 aa)
I79_009364Transcription factor AP-2 alpha. (411 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
I79_010073Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
Acvr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Tmem119Transmembrane protein 119. (277 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
NipblNipped-B-like protein. (104 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
Atp2b1Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (384 aa)
I79_011367Plasma membrane calcium-transporting ATPase 1. (327 aa)
Adgrv1G-protein coupled receptor 98. (128 aa)
I79_011453G-protein coupled receptor 98. (5280 aa)
KlKlotho. (900 aa)
Acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (559 aa)
I79_013535Fibrillin-3. (1889 aa)
I79_014629Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (369 aa)
Fam20cDentin matrix protein 4. (776 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
I79_016411G-protein coupled receptor 98. (86 aa)
PthParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (114 aa)
Zbtb16Zinc finger and BTB domain-containing protein 16. (423 aa)
I79_017450Zinc finger and BTB domain-containing protein 16. (236 aa)
I79_017864Fibrillin-2. (2601 aa)
Isg15Ubiquitin-like protein ISG15-like protein. (156 aa)
Actn3Alpha-actinin-3. (900 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Alox5Arachidonate 5-lipoxygenase. (674 aa)
I79_022080Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (402 aa)
Adrb2Beta-2 adrenergic receptor. (337 aa)
Tob2Protein Tob2. (345 aa)
Ano6Anoctamin. (319 aa)
I79_024611Signal peptide, CUB and EGF-like domain-containing protein 2. (583 aa)
I79_025277Anoctamin. (281 aa)
I79_025400Anoctamin. (273 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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