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Plcg1 Plcg1 Gba Gba Acer1 Acer1 Pck2 Pck2 Akr1b1 Akr1b1 H671_4g13290 H671_4g13290 Sptlc3 Sptlc3 Cidea Cidea Ippk Ippk Ppip5k2 Ppip5k2 Qdpr Qdpr I79_013772 I79_013772 Sphk1 Sphk1 I79_014837 I79_014837 Itpkb Itpkb I79_015207 I79_015207 I79_015220 I79_015220 Pgp Pgp Tmem130 Tmem130 Spr Spr Sptlc1 Sptlc1 I79_017016 I79_017016 Ephx1 Ephx1 Impa1 Impa1 I79_019154 I79_019154 Ip6k3 Ip6k3 Acer3 Acer3 I79_022226 I79_022226 I79_022230 I79_022230 Abca2 Abca2 I79_024172 I79_024172 I79_025163 I79_025163 Plcg2 Plcg2 Scp2 Scp2 Acer2 Acer2 Lep Lep Asah1 Asah1 Got1 Got1 Ppip5k1 Ppip5k1 Itpka Itpka Ptafr Ptafr Pts Pts Isyna1 Isyna1 Ipmk Ipmk Sptlc2 Sptlc2 I79_005787 I79_005787 Pcbd1 Pcbd1 Gch1 Gch1 Ip6k1 Ip6k1 Pck1 Pck1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Plcg1Phosphoinositide phospholipase C. (1217 aa)
GbaGlucosylceramidase. (515 aa)
Acer1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
Pck2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
Akr1b1Aldose reductase. (316 aa)
H671_4g13290Kinase; Belongs to the inositol phosphokinase (IPK) family. (332 aa)
Sptlc3Serine palmitoyltransferase 3. (853 aa)
CideaInositol monophosphatase 2. (448 aa)
IppkInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (489 aa)
Ppip5k2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1184 aa)
QdprDihydropteridine reductase-like protein. (241 aa)
I79_013772Vitamin D 25-hydroxylase. (391 aa)
Sphk1Sphingosine kinase 1. (383 aa)
I79_014837Epoxide hydrolase 1. (66 aa)
ItpkbKinase; Belongs to the inositol phosphokinase (IPK) family. (789 aa)
I79_01520725-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
I79_015220Neutral ceramidase. (474 aa)
PgpPhosphoglycolate phosphatase. (617 aa)
Tmem130Transmembrane protein 130. (461 aa)
SprSepiapterin reductase. (262 aa)
Sptlc1Serine palmitoyltransferase 1. (473 aa)
I79_017016Epoxide hydrolase 1. (244 aa)
Ephx1Epoxide hydrolase 1. (217 aa)
Impa1Inositol-1-monophosphatase. (236 aa)
I79_019154Sepiapterin reductase. (117 aa)
Ip6k3Kinase; Belongs to the inositol phosphokinase (IPK) family. (396 aa)
Acer3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
I79_022226Sepiapterin reductase. (114 aa)
I79_022230Sepiapterin reductase. (131 aa)
Abca2ATP-binding cassette sub-family A member 2. (457 aa)
I79_024172Aldose reductase. (150 aa)
I79_025163Sepiapterin reductase. (110 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
Scp2Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
Acer2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Asah1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
Got1Aspartate aminotransferase. (413 aa)
Ppip5k1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1510 aa)
ItpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (289 aa)
PtafrPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
Pts6-pyruvoyl tetrahydrobiopterin synthase-like protein. (144 aa)
Isyna1Inositol-3-phosphate synthase 1. (430 aa)
IpmkKinase; Belongs to the inositol phosphokinase (IPK) family. (322 aa)
Sptlc2Serine palmitoyltransferase 2. (425 aa)
I79_005787Serine palmitoyltransferase 2. (77 aa)
Pcbd1Pterin-4-alpha-carbinolamine dehydratase. (103 aa)
Gch1GTP cyclohydrolase 1. (248 aa)
Ip6k1Kinase; Belongs to the inositol phosphokinase (IPK) family. (427 aa)
Pck1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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