(94 nodes) Positive regulation of JNK cascade network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ncf1	Neutrophil cytosol factor 1. (303 aa)
	Wnt7a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
	I79_000439	Phosphoinositide phospholipase C. (949 aa)
	I79_000688	Ankyrin repeat domain-containing protein 6. (498 aa)
	I79_000697	Mitogen-activated protein kinase kinase kinase 7. (287 aa)
	Taok3	Serine/threonine-protein kinase TAO3. (898 aa)
	I79_001358	Ras-related protein Rab-44. (166 aa)
	Cracr2a	EF-hand calcium-binding domain-containing protein 4B. (567 aa)
	Ltbr	Tumor necrosis factor receptor superfamily member 3. (412 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Dusp22	Dual specificity protein phosphatase 22. (197 aa)
	I79_002793	Traf2 and NCK-interacting protein kinase. (160 aa)
	I79_002794	Misshapen-like kinase 1. (851 aa)
	Mapk8ip1	C-jun-amino-terminal kinase-interacting protein 1. (617 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Map2k4	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (342 aa)
	Mfhas1	Malignant fibrous histiocytoma-amplified sequence 1-like. (1025 aa)
	Dixdc1	Dixin. (689 aa)
	Traf5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	F2rl1	Proteinase-activated receptor 2. (374 aa)
	Traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	Sh3rf1	Putative E3 ubiquitin-protein ligase SH3RF1. (885 aa)
	Pja2	E3 ubiquitin-protein ligase Praja2. (699 aa)
	Nod2	Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
	I79_005745	NADPH oxidase 1. (395 aa)
	I79_005953	Mitogen-activated protein kinase kinase kinase kinase 4. (1094 aa)
	Dusp19	Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
	Tnfrsf19	Tumor necrosis factor receptor superfamily member 19. (414 aa)
	I79_007935	C-jun-amino-terminal kinase-interacting protein 3. (95 aa)
	Mapk8ip3	C-jun-amino-terminal kinase-interacting protein 3. (1073 aa)
	Axin1	Axin-1. (863 aa)
	I79_009350	Toll/interleukin-1 receptor domain-containing adapter protein. (245 aa)
	Tnfsf11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
	I79_009834	Disabled-like 2. (705 aa)
	I79_009874	Baculoviral IAP repeat-containing protein 7. (196 aa)
	Sh3rf2	Putative E3 ubiquitin-protein ligase SH3RF2. (736 aa)
	Rasgrp1	RAS guanyl-releasing protein 1. (787 aa)
	Map3k1	Mitogen-activated protein kinase kinase kinase 1. (1340 aa)
	Trpv4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
	Gadd45g	Growth arrest and DNA-damage-inducible protein GADD45 gamma. (165 aa)
	Cdc42	Cell division control protein 42-like. (191 aa)
	I79_010559	Baculoviral IAP repeat-containing protein 1b. (968 aa)
	I79_010651	Tumor necrosis factor receptor superfamily member EDAR. (403 aa)
	I79_010652	SH3 domain-containing RING finger protein 3. (652 aa)
	Stk3	Serine/threonine-protein kinase 3. (260 aa)
	Znf622	Zinc finger protein 622. (478 aa)
	App	Amyloid beta A4 protein. (433 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	I79_012336	Protein tyrosine kinase 2 beta. (53 aa)
	I79_012394	Mitogen-activated protein kinase kinase kinase 10. (594 aa)
	I79_012556	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1227 aa)
	Ripk2	Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Taok1	Serine/threonine-protein kinase TAO1. (723 aa)
	Map2k7	Dual specificity mitogen-activated protein kinase kinase 7. (391 aa)
	I79_013577	Baculoviral IAP repeat-containing protein 1b. (199 aa)
	I79_013578	Baculoviral IAP repeat-containing protein 1a. (291 aa)
	I79_013579	Baculoviral IAP repeat-containing protein 1a. (197 aa)
	Gadd45b	Growth arrest and DNA-damage-inducible protein GADD45 beta. (232 aa)
	Crk	Proto-oncogene C-crk. (327 aa)
	Eda2r	Tumor necrosis factor receptor superfamily member 27. (297 aa)
	I79_014483	Serine/threonine-protein kinase 3. (118 aa)
	Nod1	Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
	Dab2ip	Disabled-like 2-interacting protein. (1065 aa)
	Ager	Advanced glycosylation end product-specific receptor. (334 aa)
	I79_016423	Advanced glycosylation end product-specific receptor. (65 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	I79_016897	Traf2 and NCK-interacting protein kinase. (574 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Hras	GTPase HRas-like protein. (189 aa)
	Fgf19	Fibroblast growth factor 15; Belongs to the heparin-binding growth factors family. (115 aa)
	Taok2	Serine/threonine-protein kinase TAO2. (1242 aa)
	Map4k2	Mitogen-activated protein kinase kinase kinase kinase 2. (259 aa)
	I79_019425	Apoptosis-associated speck-like protein containing a CARD. (192 aa)
	Xiap	Baculoviral IAP repeat-containing protein 4. (441 aa)
	I79_020369	UNC5C-like protein. (530 aa)
	I79_020594	Tumor protein D53. (162 aa)
	Ccn2	Connective tissue growth factor-like protein. (348 aa)
	Fgd4	FYVE, RhoGEF and PH domain-containing protein 4. (665 aa)
	Rb1cc1	RB1-inducible coiled-coil protein 1. (1464 aa)
	Wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Map3k11	Mitogen-activated protein kinase kinase kinase. (850 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	Ripk1	Receptor-interacting serine/threonine-protein kinase 1. (655 aa)
	Traf4	TNF receptor-associated factor. (470 aa)
	Traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	I79_023695	Malignant fibrous histiocytoma-amplified sequence 1-like. (200 aa)
	Traf1	TNF receptor-associated factor 1. (298 aa)
	Mbip	MAP3K12-binding inhibitory protein 1. (341 aa)
	I79_024526	Alpha-2-antiplasmin; Belongs to the serpin family. (442 aa)
	I79_025690	Malignant fibrous histiocytoma-amplified sequence 1. (391 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ager	App	G3HZC3	G3HMG4	Advanced glycosylation end product-specific receptor.	Amyloid beta A4 protein.	0.589
Ager	Hras	G3HZC3	G3I3F4	Advanced glycosylation end product-specific receptor.	GTPase HRas-like protein.	0.907
Ager	Tnf	G3HZC3	G3HZG9	Advanced glycosylation end product-specific receptor.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.440
App	Ager	G3HMG4	G3HZC3	Amyloid beta A4 protein.	Advanced glycosylation end product-specific receptor.	0.589
App	I79_000439	G3HMG4	G3GSB8	Amyloid beta A4 protein.	Phosphoinositide phospholipase C.	0.442
App	I79_000688	G3HMG4	G3GSS0	Amyloid beta A4 protein.	Ankyrin repeat domain-containing protein 6.	0.699
App	I79_016423	G3HMG4	G3HZC4	Amyloid beta A4 protein.	Advanced glycosylation end product-specific receptor.	0.511
App	IL1B	G3HMG4	G3I1B0	Amyloid beta A4 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.487
App	Mapk8ip1	G3HMG4	G3GYH8	Amyloid beta A4 protein.	C-jun-amino-terminal kinase-interacting protein 1.	0.777
App	Tnf	G3HMG4	G3HZG9	Amyloid beta A4 protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.449
Axin1	Dixdc1	G3HBS5	G3H2H4	Axin-1.	Dixin.	0.592
Axin1	I79_000688	G3HBS5	G3GSS0	Axin-1.	Ankyrin repeat domain-containing protein 6.	0.716
Axin1	I79_009834	G3HBS5	G3HGU3	Axin-1.	Disabled-like 2.	0.580
Axin1	Map3k1	G3HBS5	G3HHW8	Axin-1.	Mitogen-activated protein kinase kinase kinase 1.	0.681
Axin1	Wnt5a	G3HBS5	G3GUT6	Axin-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.537
Axin1	Wnt7a	G3HBS5	G3GS11	Axin-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.475
Ccl19	Ccl21	G3HN20	G3HN19	C-C motif chemokine.	C-C motif chemokine 21a.	0.990
Ccl21	Ccl19	G3HN19	G3HN20	C-C motif chemokine 21a.	C-C motif chemokine.	0.990
Ccl21	Tnf	G3HN19	G3HZG9	C-C motif chemokine 21a.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.430
Ccn2	Tnf	G3IAP3	G3HZG9	Connective tissue growth factor-like protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.401