STRINGSTRING
Gsk3a Gsk3a Hlx Hlx Kcnk2 Kcnk2 Prox1 Prox1 Foxp1 Foxp1 Wwc2 Wwc2 Tbx5 Tbx5 Jarid2 Jarid2 Ccnd2 Ccnd2 I79_001484 I79_001484 Tgfbr2 Tgfbr2 Agt Agt Rag2 Rag2 Smo Smo Fgf20 Fgf20 I79_003468 I79_003468 Edn1 Edn1 Cav3 Cav3 Meis1 Meis1 Nog Nog I79_004031 I79_004031 I79_004399 I79_004399 Akt1 Akt1 Lats1 Lats1 Rgs2 Rgs2 I79_005331 I79_005331 Igf1 Igf1 I79_005909 I79_005909 Cxadr Cxadr I79_006190 I79_006190 Tgfbr1 Tgfbr1 I79_006562 I79_006562 I79_006679 I79_006679 Lats2 Lats2 Rbp4 Rbp4 Tbx2 Tbx2 Wnt2 Wnt2 I79_007089 I79_007089 I79_007090 I79_007090 I79_007135 I79_007135 Sirt1 Sirt1 Mef2c Mef2c I79_007989 I79_007989 Trip10 Trip10 Ctdp1 Ctdp1 H671_5g13635 H671_5g13635 Tgfbr3 Tgfbr3 I79_009001 I79_009001 Apc Apc I79_009500 I79_009500 Serp1 Serp1 Hdac2 Hdac2 I79_010352 I79_010352 Bmp10 Bmp10 Stk3 Stk3 I79_011152 I79_011152 Pim1 Pim1 Ankrd30a Ankrd30a Dusp6 Dusp6 Stk4 Stk4 Tomm70 Tomm70 Slc6a4 Slc6a4 I79_013531 I79_013531 Dusp9 Dusp9 I79_014045 I79_014045 I79_014483 I79_014483 Vgll4 Vgll4 Cdk1 Cdk1 Gli1 Gli1 Npm3 Npm3 I79_015916 I79_015916 H671_xg20591 H671_xg20591 I79_016358 I79_016358 Flvcr1 Flvcr1 Ddx39b Ddx39b Mapk14 Mapk14 Wwc3 Wwc3 I79_017320 I79_017320 I79_017749 I79_017749 I79_018586 I79_018586 Tbx20 Tbx20 Ybx3 Ybx3 Men1 Men1 I79_019149 I79_019149 Ptk2 Ptk2 Slc25a4 Slc25a4 Akap6 Akap6 I79_020783 I79_020783 Hey2 Hey2 G6pd G6pd Rbpj Rbpj Sav1 Sav1 Mtor Mtor I79_022390 I79_022390 Ppara Ppara I79_022786 I79_022786 I79_023178 I79_023178 I79_023241 I79_023241 Tcf7l2 Tcf7l2 Fgfr2 Fgfr2 Fxn Fxn I79_024406 I79_024406 Pak1 Pak1 I79_024997 I79_024997 Dspp Dspp I79_025549 I79_025549 I79_025570 I79_025570 I79_025672 I79_025672 I79_025858 I79_025858 I79_025994 I79_025994 I79_026256 I79_026256 Gja1 Gja1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gsk3aGlycogen synthase kinase-3 alpha. (653 aa)
HlxH2.0-like homeobox protein. (374 aa)
Kcnk2Potassium channel subfamily K member 2. (215 aa)
Prox1Prospero homeobox protein 1. (738 aa)
Foxp1Forkhead box protein P1. (696 aa)
Wwc2Protein WWC2. (1088 aa)
Tbx5T-box transcription factor TBX5. (518 aa)
Jarid2Protein Jumonji. (1221 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
Rag2V(D)J recombination-activating protein 2. (527 aa)
SmoSmoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
I79_003468Bcl-2-like protein 11. (141 aa)
Edn1Endothelin-1. (202 aa)
Cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
Meis1Homeobox protein Meis1. (390 aa)
NogNoggin. (117 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
I79_004399Neural cell adhesion molecule 1. (1071 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Lats1Serine/threonine-protein kinase LATS1. (1130 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005909Peptidyl-prolyl cis-trans isomerase. (242 aa)
CxadrCoxsackievirus and adenovirus receptor-like. (394 aa)
I79_006190Uncharacterized protein. (240 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
I79_006562Voltage-dependent L-type calcium channel subunit alpha-1C. (1112 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Lats2Serine/threonine-protein kinase LATS2. (1040 aa)
Rbp4Retinol-binding protein 4; Belongs to the calycin superfamily. Lipocalin family. (338 aa)
Tbx2T-box transcription factor TBX2. (234 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007135Homeobox protein Nkx-2.5. (223 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
I79_007989Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (375 aa)
Trip10Cdc42-interacting protein 4. (610 aa)
Ctdp1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (848 aa)
H671_5g13635Protein maelstrom-like. (172 aa)
Tgfbr3TGF-beta receptor type III. (849 aa)
I79_009001Zinc finger protein ZFPM2. (718 aa)
ApcAdenomatous polyposis coli protein. (2488 aa)
I79_009500Mitogen-activated protein kinase 1. (68 aa)
Serp1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
I79_010352Acetyl-CoA carboxylase 2. (2287 aa)
Bmp10Bone morphogenetic protein 10. (399 aa)
Stk3Serine/threonine-protein kinase 3. (260 aa)
I79_011152Peptidase inhibitor 16; Belongs to the CRISP family. (396 aa)
Pim1Proto-oncogene serine/threonine-protein kinase Pim-1. (250 aa)
Ankrd30aAnkyrin repeat domain-containing protein 26. (1699 aa)
Dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
Stk4Serine/threonine-protein kinase 4. (487 aa)
Tomm70Mitochondrial import receptor subunit TOM70. (384 aa)
Slc6a4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (520 aa)
I79_013531Ankyrin repeat domain-containing protein 26. (390 aa)
Dusp9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (335 aa)
I79_014045Ankyrin repeat domain-containing protein 26. (102 aa)
I79_014483Serine/threonine-protein kinase 3. (118 aa)
Vgll4Transcription cofactor vestigial-like protein 4. (282 aa)
Cdk1Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
Gli1Zinc finger protein GLI1. (1104 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
I79_015916Insulin-like growth factor II. (155 aa)
H671_xg20591Homeobox protein ARX-like protein. (279 aa)
I79_016358Feline leukemia virus subgroup C receptor-related protein 1. (100 aa)
Flvcr1Feline leukemia virus subgroup C receptor-related protein 1. (222 aa)
Ddx39bSpliceosome RNA helicase BAT1. (288 aa)
Mapk14Mitogen-activated protein kinase. (349 aa)
Wwc3Protein WWC3. (1088 aa)
I79_017320Poly [ADP-ribose] polymerase. (513 aa)
I79_017749Mitogen-activated protein kinase 11. (413 aa)
I79_018586Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
Tbx20T-box transcription factor TBX20. (445 aa)
Ybx3DNA-binding protein A. (103 aa)
Men1Menin. (610 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
Slc25a4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (272 aa)
Akap6A-kinase anchor protein 6. (1368 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
Hey2Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
G6pdGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (624 aa)
RbpjRecombining binding protein suppressor of hairless-like protein. (486 aa)
Sav1Protein salvador-like 1. (210 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
I79_022786Ankyrin repeat domain-containing protein 26. (249 aa)
I79_023178Zinc finger protein 551. (887 aa)
I79_023241Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (558 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
FxnFrataxin, mitochondrial. (136 aa)
I79_024406A-kinase anchor protein 6. (211 aa)
Pak1Serine/threonine-protein kinase PAK 1. (325 aa)
I79_024997Ankyrin repeat domain-containing protein 26. (238 aa)
DsppDentin sialophosphoprotein. (859 aa)
I79_025549WNT1-inducible-signaling pathway protein 1. (274 aa)
I79_025570Spliceosome RNA helicase Bat1. (229 aa)
I79_025672Spliceosome RNA helicase BAT1. (155 aa)
I79_025858Spliceosome RNA helicase BAT1. (66 aa)
I79_025994WNT1-inducible-signaling pathway protein 1. (136 aa)
I79_026256Spliceosome RNA helicase Bat1. (103 aa)
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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