(18 nodes) Insulin-like growth factor receptor signaling pathway network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Igf1	Insulin-like growth factor I. (75 aa)
	Ar	Androgen receptor. (517 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Ghr	Growth hormone receptor. (345 aa)
	Gigyf2	PERQ amino acid-rich with GYF domain-containing protein 2. (1298 aa)
	I79_019286	Androgen receptor. (295 aa)
	I79_018982	PERQ amino acid-rich with GYF domain-containing protein 2. (102 aa)
	Gigyf1	PERQ amino acid-rich with GYF domain-containing protein 1. (60 aa)
	Igf1r	Insulin-like growth factor 1 receptor. (191 aa)
	I79_010839	Eukaryotic translation initiation factor 2-alpha kinase 3. (783 aa)
	Atxn7	Ataxin-7. (756 aa)
	I79_009691	Growth factor receptor-bound protein 10. (518 aa)
	Tsc2	Tuberin. (1546 aa)
	Ghsr	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Igfbp5	Insulin-like growth factor-binding protein 5. (271 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	I79_000439	Phosphoinositide phospholipase C. (949 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Ar	G3H397	G3IGU9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Androgen receptor.	0.446
Akt1	I79_019286	G3H397	G3I705	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Androgen receptor.	0.446
Akt1	Igf1	G3H397	G3H672	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I.	0.710
Akt1	Irs1	G3H397	G3IDC4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.724
Akt1	Pik3r1	G3H397	G3H4N4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.974
Akt1	Tsc2	G3H397	G3HBQ8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tuberin.	0.976
Ar	Akt1	G3IGU9	G3H397	Androgen receptor.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.446
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ar	Igf1	G3IGU9	G3H672	Androgen receptor.	Insulin-like growth factor I.	0.435
Ar	Igf1r	G3IGU9	G3HKI5	Androgen receptor.	Insulin-like growth factor 1 receptor.	0.527
Ghr	Igf1	G3ID70	G3H672	Growth hormone receptor.	Insulin-like growth factor I.	0.619
Ghr	Igf1r	G3ID70	G3HKI5	Growth hormone receptor.	Insulin-like growth factor 1 receptor.	0.508
Ghsr	I79_000439	G3H6H3	G3GSB8	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	Phosphoinositide phospholipase C.	0.434
Gigyf1	I79_009691	G3I669	G3HGG4	PERQ amino acid-rich with GYF domain-containing protein 1.	Growth factor receptor-bound protein 10.	0.576
Gigyf2	I79_009691	G3I9L4	G3HGG4	PERQ amino acid-rich with GYF domain-containing protein 2.	Growth factor receptor-bound protein 10.	0.692
I79_000439	Ghsr	G3GSB8	G3H6H3	Phosphoinositide phospholipase C.	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.434
I79_009691	Gigyf1	G3HGG4	G3I669	Growth factor receptor-bound protein 10.	PERQ amino acid-rich with GYF domain-containing protein 1.	0.576
I79_009691	Gigyf2	G3HGG4	G3I9L4	Growth factor receptor-bound protein 10.	PERQ amino acid-rich with GYF domain-containing protein 2.	0.692
I79_009691	I79_010839	G3HGG4	G3HJJ2	Growth factor receptor-bound protein 10.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.501
I79_009691	I79_018982	G3HGG4	G3I670	Growth factor receptor-bound protein 10.	PERQ amino acid-rich with GYF domain-containing protein 2.	0.576