(51 nodes) Developmental pigmentation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Dct	L-dopachrome tautomerase. (517 aa)
	Mitf	Microphthalmia-associated transcription factor. (474 aa)
	Adamts9	A disintegrin and metalloproteinase with thrombospondin motifs 9. (489 aa)
	I79_000337	A disintegrin and metalloproteinase with thrombospondin motifs 9. (1068 aa)
	Rab27a	Ras-related protein Rab-27A. (221 aa)
	I79_000133	Myosin-Va; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1737 aa)
	I79_000368	Microphthalmia-associated transcription factor. (106 aa)
	Kit	Mast/stem cell growth factor receptor. (452 aa)
	I79_024904	Guanine nucleotide-binding protein G(Q) subunit alpha. (112 aa)
	I79_024520	Guanine nucleotide-binding protein subunit alpha-11. (61 aa)
	I79_024477	A disintegrin and metalloproteinase with thrombospondin motifs 20. (601 aa)
	I79_024370	Microphthalmia-associated transcription factor. (185 aa)
	I79_024314	Paired box protein Pax-3. (301 aa)
	I79_024048	Paired box protein Pax-3. (324 aa)
	H671_3g10186	Olfactory receptor. (320 aa)
	I79_020815	A disintegrin and metalloproteinase with thrombospondin motifs 20. (488 aa)
	Enpp1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
	Gnaq	Guanine nucleotide-binding protein G(Q) subunit alpha. (220 aa)
	Rab38	Ras-related protein Rab-38-like protein. (211 aa)
	Rab32	Ras-related protein Rab-32. (223 aa)
	I79_018617	5,6-dihydroxyindole-2-carboxylic acid oxidase. (256 aa)
	Sox10	Transcription factor SOX-10. (466 aa)
	Hps5	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1128 aa)
	I79_016567	Zinc finger E-box-binding homeobox 2. (1282 aa)
	Hps6	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (806 aa)
	Sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
	I79_014974	Beta-adrenergic receptor kinase 2; Belongs to the protein kinase superfamily. (338 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	I79_014139	Hermansky-Pudlak syndrome 4 protein-like. (552 aa)
	I79_014133	Beta-adrenergic receptor kinase 2. (175 aa)
	I79_014089	P protein. (398 aa)
	Gna11	Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
	Slc24a5	Sodium/potassium/calcium exchanger 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (296 aa)
	Cd63	Tetraspanin. (232 aa)
	Bloc1s6	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
	I79_010521	Membrane-associated transporter protein. (482 aa)
	I79_010290	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	Ap3d1	AP-3 complex subunit delta-1. (1199 aa)
	I79_009172	Ankyrin repeat domain-containing protein 27. (845 aa)
	Bloc1s5	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (189 aa)
	Mef2c	Myocyte-specific enhancer factor 2C. (465 aa)
	Ap1g1	AP-1 complex subunit gamma. (822 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Ap1m1	AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (441 aa)
	Mreg	Melanoregulin. (158 aa)
	Adamtsl4	ADAMTS-like protein 4. (1043 aa)
	I79_003468	Bcl-2-like protein 11. (141 aa)
	Hps1	Hermansky-Pudlak syndrome 1 protein-like. (653 aa)
	Vhl	Von Hippel-Lindau disease tumor suppressor. (134 aa)
	Edn3	Endothelin-3. (274 aa)
	Atp6ap2	Renin receptor. (300 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adamts9	Adamtsl4	G3GS31	G3H2W8	A disintegrin and metalloproteinase with thrombospondin motifs 9.	ADAMTS-like protein 4.	0.566
Adamts9	I79_000337	G3GS31	G3GS30	A disintegrin and metalloproteinase with thrombospondin motifs 9.	A disintegrin and metalloproteinase with thrombospondin motifs 9.	0.839
Adamts9	I79_024477	G3GS31	G3IKS4	A disintegrin and metalloproteinase with thrombospondin motifs 9.	A disintegrin and metalloproteinase with thrombospondin motifs 20.	0.792
Adamtsl4	Adamts9	G3H2W8	G3GS31	ADAMTS-like protein 4.	A disintegrin and metalloproteinase with thrombospondin motifs 9.	0.566
Ap1g1	Ap1m1	G3HAG8	G3H4H6	AP-1 complex subunit gamma.	AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.998
Ap1g1	Ap3d1	G3HAG8	G3HFA8	AP-1 complex subunit gamma.	AP-3 complex subunit delta-1.	0.522
Ap1m1	Ap1g1	G3H4H6	G3HAG8	AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	AP-1 complex subunit gamma.	0.998
Ap1m1	Ap3d1	G3H4H6	G3HFA8	AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	AP-3 complex subunit delta-1.	0.717
Ap3d1	Ap1g1	G3HFA8	G3HAG8	AP-3 complex subunit delta-1.	AP-1 complex subunit gamma.	0.522
Ap3d1	Ap1m1	G3HFA8	G3H4H6	AP-3 complex subunit delta-1.	AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.717
Ap3d1	Bloc1s6	G3HFA8	G3HMD4	AP-3 complex subunit delta-1.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.434
Ap3d1	Hps5	G3HFA8	G3I253	AP-3 complex subunit delta-1.	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.591
Ap3d1	Hps6	G3HFA8	G3HXV2	AP-3 complex subunit delta-1.	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.564
Ap3d1	I79_009172	G3HFA8	G3HF20	AP-3 complex subunit delta-1.	Ankyrin repeat domain-containing protein 27.	0.580
Bloc1s5	Bloc1s6	G3HD99	G3HMD4	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.887
Bloc1s5	Hps5	G3HD99	G3I253	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.609
Bloc1s5	Hps6	G3HD99	G3HXV2	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.595
Bloc1s6	Ap3d1	G3HMD4	G3HFA8	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	AP-3 complex subunit delta-1.	0.434
Bloc1s6	Bloc1s5	G3HMD4	G3HD99	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).	0.887
Bloc1s6	Hps5	G3HMD4	G3I253	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.746