(14 nodes) Astrocyte activation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Grn	Granulins. (592 aa)
	Ifngr1	Interferon-gamma receptor alpha chain. (471 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	Ager	Advanced glycosylation end product-specific receptor. (334 aa)
	Adora2a	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	App	Amyloid beta A4 protein. (433 aa)
	I79_009291	Beta-secretase 2; Belongs to the peptidase A1 family. (378 aa)
	I79_016423	Advanced glycosylation end product-specific receptor. (65 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Cntf	Ciliary neurotrophic factor. (59 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ager	App	G3HZC3	G3HMG4	Advanced glycosylation end product-specific receptor.	Amyloid beta A4 protein.	0.589
Agt	App	G3GX14	G3HMG4	Angiotensinogen; Belongs to the serpin family.	Amyloid beta A4 protein.	0.456
App	Ager	G3HMG4	G3HZC3	Amyloid beta A4 protein.	Advanced glycosylation end product-specific receptor.	0.589
App	Agt	G3HMG4	G3GX14	Amyloid beta A4 protein.	Angiotensinogen; Belongs to the serpin family.	0.456
App	I79_008941	G3HMG4	G3HEF7	Amyloid beta A4 protein.	Receptor protein-tyrosine kinase.	0.493
App	I79_009291	G3HMG4	G3HFD5	Amyloid beta A4 protein.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.779
App	I79_016423	G3HMG4	G3HZC4	Amyloid beta A4 protein.	Advanced glycosylation end product-specific receptor.	0.511
App	IL1B	G3HMG4	G3I1B0	Amyloid beta A4 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.487
App	Lrp1	G3HMG4	G3HW34	Amyloid beta A4 protein.	Prolow-density lipoprotein receptor-related protein 1.	0.648
App	Psen1	G3HMG4	G3HNF2	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
Cntf	Ifngr1	G3IIP9	G3GW63	Ciliary neurotrophic factor.	Interferon-gamma receptor alpha chain.	0.687
Cntf	Smo	G3IIP9	G3GZ55	Ciliary neurotrophic factor.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.484
I79_008941	App	G3HEF7	G3HMG4	Receptor protein-tyrosine kinase.	Amyloid beta A4 protein.	0.493
I79_008941	IL1B	G3HEF7	G3I1B0	Receptor protein-tyrosine kinase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.557
I79_008941	Lrp1	G3HEF7	G3HW34	Receptor protein-tyrosine kinase.	Prolow-density lipoprotein receptor-related protein 1.	0.461
I79_009291	App	G3HFD5	G3HMG4	Beta-secretase 2; Belongs to the peptidase A1 family.	Amyloid beta A4 protein.	0.779
I79_009291	Psen1	G3HFD5	G3HNF2	Beta-secretase 2; Belongs to the peptidase A1 family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.426
I79_016423	App	G3HZC4	G3HMG4	Advanced glycosylation end product-specific receptor.	Amyloid beta A4 protein.	0.511
IL1B	App	G3I1B0	G3HMG4	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Amyloid beta A4 protein.	0.487
IL1B	I79_008941	G3I1B0	G3HEF7	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Receptor protein-tyrosine kinase.	0.557