(53 nodes) Autonomic nervous system development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	Hlx	H2.0-like homeobox protein. (374 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
	I79_001046	Neurofibromin. (2164 aa)
	Ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
	Fzd3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	Phactr4	Phosphatase and actin regulator. (370 aa)
	Hoxb2	Homeobox protein Hox-B2. (407 aa)
	Hoxb1	Homeobox protein Hox-B1. (297 aa)
	Ascl1	Achaete-scute-like 1. (140 aa)
	I79_006190	Uncharacterized protein. (240 aa)
	Sema3f	Semaphorin-3F; Belongs to the semaphorin family. (785 aa)
	Adarb1	Double-stranded RNA-specific editase 1. (701 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	Hoxa1	Homeobox protein Hox-A1. (334 aa)
	Nrp2	Neuropilin; Belongs to the neuropilin family. (909 aa)
	Nav2	Neuron navigator 2. (2028 aa)
	I79_009030	T-box transcription factor TBX1. (293 aa)
	I79_009364	Transcription factor AP-2 alpha. (411 aa)
	I79_009585	Tyrosine-protein kinase receptor. (727 aa)
	I79_010290	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	Ret	Proto-oncogene tyrosine-protein kinase receptor ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1432 aa)
	Sema3a	Semaphorin-3A-like protein; Belongs to the semaphorin family. (758 aa)
	Plxna4	Plexin-A4. (1078 aa)
	I79_012231	Plexin-A4. (332 aa)
	I79_012894	Transcription factor AP-2 beta. (287 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	H671_xg20591	Homeobox protein ARX-like protein. (279 aa)
	I79_016262	Homeobox domain-containing protein. (72 aa)
	I79_016263	Short stature homeobox protein. (177 aa)
	I79_016264	Rhox homeobox family member 2B. (215 aa)
	I79_016265	Homeobox domain-containing protein. (171 aa)
	Nrp1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	Fn1	Fibronectin. (2486 aa)
	I79_018218	Plexin-A4. (498 aa)
	Sox10	Transcription factor SOX-10. (466 aa)
	Plxna3	Plexin-A3. (656 aa)
	I79_021038	Plexin-A3. (334 aa)
	I79_021503	Paired mesoderm homeobox protein 2A. (139 aa)
	I79_021530	Homeobox protein unc-4. (185 aa)
	Vcam1	Vascular cell adhesion protein 1. (220 aa)
	Prlh	Prolactin-releasing peptide. (87 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	Gbx2	Homeobox protein GBX-2. (222 aa)
	I79_024097	Vascular cell adhesion protein 1. (225 aa)
	Hes3	Transcription factor HES-3. (201 aa)
	I79_024341	Paired mesoderm homeobox protein 2B. (182 aa)
	I79_024529	Rhox homeobox family member 1. (174 aa)
	Ackr3	C-X-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	Egr2	Early growth response protein 2. (410 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ascl1	Gata3	G3H670	G3GR59	Achaete-scute-like 1.	Trans-acting T-cell-specific transcription factor GATA-3.	0.445
Ascl1	Hoxb1	G3H670	G3H5T3	Achaete-scute-like 1.	Homeobox protein Hox-B1.	0.434
Ascl1	I79_015503	G3H670	G3HWY8	Achaete-scute-like 1.	Transcription factor HES-1.	0.596
Ctnnb1	Fzd3	G3H996	G3H0J5	Catenin beta-1.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
Ctnnb1	I79_009585	G3H996	G3HG66	Catenin beta-1.	Tyrosine-protein kinase receptor.	0.468
Ctnnb1	Sox10	G3H996	G3I510	Catenin beta-1.	Transcription factor SOX-10.	0.641
Ctnnb1	Sox8	G3H996	G3HBV8	Catenin beta-1.	Transcription factor SOX-8.	0.589
Ednra	I79_010290	G3H9A8	G3HI25	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family.	0.769
Egr2	Gata3	G3IP22	G3GR59	Early growth response protein 2.	Trans-acting T-cell-specific transcription factor GATA-3.	0.573
Egr2	Sox10	G3IP22	G3I510	Early growth response protein 2.	Transcription factor SOX-10.	0.753
Egr2	Sox8	G3IP22	G3HBV8	Early growth response protein 2.	Transcription factor SOX-8.	0.551
Fzd3	Ctnnb1	G3H0J5	G3H996	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta-1.	0.543
Gata3	Ascl1	G3GR59	G3H670	Trans-acting T-cell-specific transcription factor GATA-3.	Achaete-scute-like 1.	0.445
Gata3	Egr2	G3GR59	G3IP22	Trans-acting T-cell-specific transcription factor GATA-3.	Early growth response protein 2.	0.573
Gata3	I79_024341	G3GR59	G3IKE0	Trans-acting T-cell-specific transcription factor GATA-3.	Paired mesoderm homeobox protein 2B.	0.553
Gdnf	I79_009585	G3HJV8	G3HG66	Glial cell line-derived neurotrophic factor.	Tyrosine-protein kinase receptor.	0.615
Gdnf	Ntf3	G3HJV8	G3GUL2	Glial cell line-derived neurotrophic factor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.704
Gdnf	Ret	G3HJV8	G3HKS9	Glial cell line-derived neurotrophic factor.	Proto-oncogene tyrosine-protein kinase receptor ret; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.908
Hoxa1	Hoxb1	G3HD70	G3H5T3	Homeobox protein Hox-A1.	Homeobox protein Hox-B1.	0.925
Hoxb1	Ascl1	G3H5T3	G3H670	Homeobox protein Hox-B1.	Achaete-scute-like 1.	0.434