STRINGSTRING
I79_003100 I79_003100 Smo Smo Nphp3 Nphp3 Sfrp5 Sfrp5 Oxtr Oxtr Gli2 Gli2 Hrh2 Hrh2 Hoxd13 Hoxd13 Tcf7 Tcf7 I79_005213 I79_005213 Rarb Rarb I79_005332 I79_005332 Klf5 Klf5 Epb41l5 Epb41l5 I79_005573 I79_005573 Sall1 Sall1 Ascl1 Ascl1 I79_005961 I79_005961 Nodal Nodal I79_006225 I79_006225 CHD8 CHD8 Ihh Ihh Prdm1 Prdm1 I79_015041 I79_015041 Gli3 Gli3 I79_014847 I79_014847 Wnt11 Wnt11 Fzd5 Fzd5 Agr2 Agr2 Ccdc39 Ccdc39 Ccdc40 Ccdc40 Spdef Spdef I79_006254 I79_006254 Vangl2 Vangl2 I79_006673 I79_006673 I79_006679 I79_006679 Smad3 Smad3 Ctnnb1 Ctnnb1 Tbx2 Tbx2 Ext1 Ext1 Smad2 Smad2 Cbfa2t2 Cbfa2t2 Slc4a2 Slc4a2 I79_007707 I79_007707 Pkd1 Pkd1 Percc1 Percc1 I79_008941 I79_008941 I79_008965 I79_008965 Cldn18 Cldn18 Tgfb3 Tgfb3 Hand1 Hand1 Crkl Crkl Cobl Cobl Gata5 Gata5 Ptk6 Ptk6 Sfrp1 Sfrp1 Acvr2b Acvr2b Hmgcs2 Hmgcs2 I79_011789 I79_011789 Ada Ada Ccdc103 Ccdc103 Cdh1 Cdh1 Fgfr3 Fgfr3 Nipbl Nipbl C1galt1 C1galt1 I79_010290 I79_010290 Il6st Il6st I79_025680 I79_025680 I79_025679 I79_025679 Ass1 Ass1 Kit Kit Col3a1 Col3a1 I79_024810 I79_024810 Pdgfra Pdgfra I79_024396 I79_024396 I79_024203 I79_024203 I79_024202 I79_024202 Fgfr2 Fgfr2 I79_023816 I79_023816 Tcf7l2 Tcf7l2 I79_023436 I79_023436 I79_023429 I79_023429 Pitx2 Pitx2 I79_023241 I79_023241 I79_023125 I79_023125 I79_022994 I79_022994 Clmp Clmp Tyms Tyms I79_022305 I79_022305 Cckbr Cckbr I79_022055 I79_022055 Yipf6 Yipf6 Sav1 Sav1 I79_021721 I79_021721 I79_020783 I79_020783 Tcf21 Tcf21 Tgfb1 Tgfb1 Ephb3 Ephb3 Vps52 Vps52 Lgr4 Lgr4 Hnf1b Hnf1b Sox10 Sox10 Sct Sct Fat4 Fat4 Foxp4 Foxp4 Tmem145 Tmem145 I79_016814 I79_016814 Tnf Tnf Dicer1 Dicer1 Hif1a Hif1a Kcnq1 Kcnq1 I79_015904 I79_015904 Nkx3-2 Nkx3-2 I79_015503 I79_015503 Alx4 Alx4 Rb1 Rb1 Hlx Hlx I79_000092 I79_000092 Aldh1a2 Aldh1a2 I79_000252 I79_000252 Foxf1 Foxf1 I79_000275 I79_000275 I79_000568 I79_000568 Tp63 Tp63 I79_000973 I79_000973 Tigar Tigar Wnt5a Wnt5a I79_001484 I79_001484 Nkx3-1 Nkx3-1 Nkx2-6 Nkx2-6 Pkdcc Pkdcc Six2 Six2 Tgfbr2 Tgfbr2 I79_001871 I79_001871 Ahi1 Ahi1 I79_001990 I79_001990 Ift172 Ift172 Foxf2 Foxf2 Src Src
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_003100Myocardin. (371 aa)
SmoSmoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
Nphp3Nephrocystin-3. (542 aa)
Sfrp5Secreted frizzled-related protein 5. (247 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (353 aa)
Gli2Zinc finger protein GLI2. (1547 aa)
Hrh2Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (358 aa)
Hoxd13Homeobox protein Hox-D13. (204 aa)
Tcf7Transcription factor 7. (213 aa)
I79_005213Nuclear receptor domain-containing protein. (162 aa)
RarbRetinoic acid receptor beta. (284 aa)
I79_005332Carbamoyl-phosphate synthase [ammonia], mitochondrial. (1309 aa)
Klf5Krueppel-like factor 5. (366 aa)
Epb41l5Band 4.1-like protein 5. (717 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
Sall1Sal-like protein 1. (1294 aa)
Ascl1Achaete-scute-like 1. (140 aa)
I79_005961Zinc finger protein ZIC 3. (89 aa)
NodalNodal. (309 aa)
I79_006225Sonic hedgehog protein. (226 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2587 aa)
IhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
Prdm1PR domain zinc finger protein 1. (825 aa)
I79_015041Thymidylate synthase. (192 aa)
Gli3Zinc finger protein GLI3. (1582 aa)
I79_014847Homeobox protein MIXL1. (125 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Fzd5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (616 aa)
Agr2Anterior gradient protein 2-like. (173 aa)
Ccdc39Coiled-coil domain-containing protein 39. (51 aa)
Ccdc40Coiled-coil domain-containing protein 40. (75 aa)
SpdefSAM pointed domain-containing Ets transcription factor. (325 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Vangl2Vang-like protein. (521 aa)
I79_006673Nck-associated protein 1. (951 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Ctnnb1Catenin beta-1. (781 aa)
Tbx2T-box transcription factor TBX2. (234 aa)
Ext1Exostosin-1. (388 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Cbfa2t2Protein CBFA2T2. (574 aa)
Slc4a2Anion exchange protein. (1236 aa)
I79_007707Retinoic acid receptor responder protein 2. (144 aa)
Pkd1Polycystin-1. (3717 aa)
Percc1Uncharacterized protein. (294 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
I79_008965Stimulated by retinoic acid gene 6 protein-like. (553 aa)
Cldn18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
Hand1Heart-and neural crest derivatives-expressed protein 1. (94 aa)
CrklCrk-like protein. (303 aa)
CoblProtein cordon-bleu. (1384 aa)
Gata5Transcription factor GATA-5. (406 aa)
Ptk6Tyrosine-protein kinase. (450 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (559 aa)
Hmgcs23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
AdaAdenosine deaminase. (363 aa)
Ccdc103Coiled-coil domain-containing protein 103. (237 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
NipblNipped-B-like protein. (104 aa)
C1galt1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1. (279 aa)
I79_010290Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
I79_025680Forkhead box protein P4. (206 aa)
I79_025679Forkhead box protein P4. (346 aa)
Ass1Argininosuccinate synthase. (242 aa)
KitMast/stem cell growth factor receptor. (452 aa)
Col3a1Collagen alpha-1(III) chain. (1051 aa)
I79_024810Cryptic protein. (69 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
I79_024396Syntaxin-2. (310 aa)
I79_024203Sal-like protein 1. (121 aa)
I79_024202Sal-like protein 1. (825 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_023816Proprotein convertase subtilisin/kexin type 5. (306 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
I79_023436Forkhead box protein P4. (104 aa)
I79_023429Forkhead box protein P4. (631 aa)
Pitx2Homeobox protein. (322 aa)
I79_023241Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (558 aa)
I79_023125Proprotein convertase subtilisin/kexin type 5. (661 aa)
I79_022994Dapper-like 1. (530 aa)
ClmpAdipocyte adhesion molecule. (343 aa)
TymsThymidylate synthase-like protein. (307 aa)
I79_022305Proprotein convertase subtilisin/kexin type 5. (170 aa)
CckbrGastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
I79_022055Argininosuccinate synthase. (97 aa)
Yipf6Protein YIPF. (235 aa)
Sav1Protein salvador-like 1. (210 aa)
I79_021721Protocadherin-16. (3015 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
Tcf21Transcription factor 21. (179 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Ephb3Ephrin type-B receptor 3. (930 aa)
Vps52Vacuolar protein sorting-associated protein 52-like. (471 aa)
Lgr4Leucine-rich repeat-containing G-protein coupled receptor 4. (231 aa)
Hnf1bHepatocyte nuclear factor 1-beta. (593 aa)
Sox10Transcription factor SOX-10. (466 aa)
SctSecretin-like protein. (132 aa)
Fat4Protocadherin Fat 4. (5152 aa)
Foxp4Forkhead box protein P4. (685 aa)
Tmem145Multiple epidermal growth factor-like domains 8. (2639 aa)
I79_016814Short stature homeobox protein 2. (194 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Dicer1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
Kcnq1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (308 aa)
I79_015904Potassium voltage-gated channel subfamily KQT member 1. (216 aa)
Nkx3-2Homeobox protein Nkx-3.2. (261 aa)
I79_015503Transcription factor HES-1. (92 aa)
Alx4Homeobox protein aristaless-like 4. (237 aa)
Rb1Retinoblastoma-associated protein. (302 aa)
HlxH2.0-like homeobox protein. (374 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Aldh1a2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (460 aa)
I79_000252Forkhead box protein L1. (334 aa)
Foxf1Forkhead box protein F1. (320 aa)
I79_000275Dynein assembly factor 1, axonemal. (437 aa)
I79_000568Ornithine carbamoyltransferase, mitochondrial. (232 aa)
Tp63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
I79_000973Transcription factor SOX-10. (360 aa)
TigarPutative fructose-2,6-bisphosphatase TIGAR. (266 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Nkx3-1Homeobox protein Nkx-3.1. (187 aa)
Nkx2-6Homeobox protein Nkx-2.6. (273 aa)
PkdccProtein kinase-like protein SgK493. (252 aa)
Six2Homeobox protein SIX2. (299 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
I79_001871Transcription factor Ovo-like 2. (213 aa)
Ahi1Jouberin. (988 aa)
I79_001990Myb proto-oncogene protein. (650 aa)
Ift172Intraflagellar transport protein 172-like. (1340 aa)
Foxf2Forkhead box protein F2. (335 aa)
SrcTyrosine-protein kinase. (536 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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