(39 nodes) Embryonic digestive tract development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Hlx	H2.0-like homeobox protein. (374 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Aldh1a2	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (460 aa)
	Foxf1	Forkhead box protein F1. (320 aa)
	Pkdcc	Protein kinase-like protein SgK493. (252 aa)
	Six2	Homeobox protein SIX2. (299 aa)
	I79_001871	Transcription factor Ovo-like 2. (213 aa)
	I79_001990	Myb proto-oncogene protein. (650 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	I79_023816	Proprotein convertase subtilisin/kexin type 5. (306 aa)
	Tcf7l2	Transcription factor 7-like 1. (73 aa)
	Pitx2	Homeobox protein. (322 aa)
	I79_023125	Proprotein convertase subtilisin/kexin type 5. (661 aa)
	I79_022305	Proprotein convertase subtilisin/kexin type 5. (170 aa)
	I79_020783	Transcription factor 7-like 2. (451 aa)
	Tcf21	Transcription factor 21. (179 aa)
	Vps52	Vacuolar protein sorting-associated protein 52-like. (471 aa)
	Hnf1b	Hepatocyte nuclear factor 1-beta. (593 aa)
	Sct	Secretin-like protein. (132 aa)
	I79_016814	Short stature homeobox protein 2. (194 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	I79_011789	DNA-binding protein inhibitor ID-2. (185 aa)
	Foxf2	Forkhead box protein F2. (335 aa)
	Gli2	Zinc finger protein GLI2. (1547 aa)
	I79_005213	Nuclear receptor domain-containing protein. (162 aa)
	Rarb	Retinoic acid receptor beta. (284 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	I79_007707	Retinoic acid receptor responder protein 2. (144 aa)
	I79_008965	Stimulated by retinoic acid gene 6 protein-like. (553 aa)
	Nipbl	Nipped-B-like protein. (104 aa)
	Ada	Adenosine deaminase. (363 aa)
	Tcf7	Transcription factor 7. (213 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fgfr2	I79_006679	G3IJY0	G3H8H9	Fibroblast growth factor receptor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.906
Fgfr2	Ihh	G3IJY0	G3HWF8	Fibroblast growth factor receptor 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.513
Fgfr2	Pdgfra	G3IJY0	G3IKN8	Fibroblast growth factor receptor 2.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.943
Foxf1	Gli2	G3GRV9	G3H142	Forkhead box protein F1.	Zinc finger protein GLI2.	0.408
Foxf1	Gli3	G3GRV9	G3HVA3	Forkhead box protein F1.	Zinc finger protein GLI3.	0.519
Foxf1	I79_006225	G3GRV9	G3H796	Forkhead box protein F1.	Sonic hedgehog protein.	0.570
Foxf1	Ihh	G3GRV9	G3HWF8	Forkhead box protein F1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.473
Gli2	Foxf1	G3H142	G3GRV9	Zinc finger protein GLI2.	Forkhead box protein F1.	0.408
Gli2	Gli3	G3H142	G3HVA3	Zinc finger protein GLI2.	Zinc finger protein GLI3.	0.968
Gli2	I79_006225	G3H142	G3H796	Zinc finger protein GLI2.	Sonic hedgehog protein.	0.698
Gli2	Ihh	G3H142	G3HWF8	Zinc finger protein GLI2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.684
Gli3	Foxf1	G3HVA3	G3GRV9	Zinc finger protein GLI3.	Forkhead box protein F1.	0.519
Gli3	Gli2	G3HVA3	G3H142	Zinc finger protein GLI3.	Zinc finger protein GLI2.	0.968
Gli3	I79_006225	G3HVA3	G3H796	Zinc finger protein GLI3.	Sonic hedgehog protein.	0.662
Gli3	Ihh	G3HVA3	G3HWF8	Zinc finger protein GLI3.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.663
I79_000092	Tnf	G3GRE7	G3HZG9	Transforming growth factor beta; Belongs to the TGF-beta family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.427
I79_005213	Rarb	G3H4K8	G3H4K9	Nuclear receptor domain-containing protein.	Retinoic acid receptor beta.	0.500
I79_006225	Foxf1	G3H796	G3GRV9	Sonic hedgehog protein.	Forkhead box protein F1.	0.570
I79_006225	Gli2	G3H796	G3H142	Sonic hedgehog protein.	Zinc finger protein GLI2.	0.698
I79_006225	Gli3	G3H796	G3HVA3	Sonic hedgehog protein.	Zinc finger protein GLI3.	0.662