STRINGSTRING
Thbs1 Thbs1 H671_xg20748 H671_xg20748 I79_009953 I79_009953 Akr1b1 Akr1b1 Itgb3 Itgb3 Mef2d Mef2d Tgfb3 Tgfb3 Elane Elane Egr1 Egr1 Comt Comt I79_008941 I79_008941 IL12B IL12B Shc1 Shc1 I79_008058 I79_008058 Il6r Il6r I79_007693 I79_007693 Cdkn1b Cdkn1b Il10 Il10 Mef2c Mef2c Gsk3b Gsk3b Cav1 Cav1 Ctnnb1 Ctnnb1 Mmp9 Mmp9 I79_006679 I79_006679 Gnai2 Gnai2 Gna13 Gna13 I79_006462 I79_006462 MED4 MED4 I79_006254 I79_006254 I79_005895 I79_005895 Dnmt1 Dnmt1 S1pr2 S1pr2 Cnn1 Cnn1 I79_005841 I79_005841 Igf1 Igf1 I79_005745 I79_005745 I79_005379 I79_005379 I79_005358 I79_005358 Gna12 Gna12 Orc1 Orc1 Tnfaip3 Tnfaip3 I79_002099 I79_002099 Ptgs2 Ptgs2 Agt Agt Src Src Alox12 Alox12 Bmpr2 Bmpr2 Traf6 Traf6 I79_003100 I79_003100 Edn1 Edn1 Tacr1 Tacr1 Pik3r1 Pik3r1 Mmp2 Mmp2 Ptafr Ptafr Il18 Il18 I79_004452 I79_004452 Akt1 Akt1 Xrcc5 Xrcc5 Igfbp5 Igfbp5 ilk ilk I79_000233 I79_000233 Cdh13 Cdh13 Foxp1 Foxp1 I79_001046 I79_001046 Vip Vip Pde4d Pde4d Tgfbr2 Tgfbr2 I79_011789 I79_011789 I79_011804 I79_011804 Apoe Apoe Rgs5 Rgs5 Ddr2 Ddr2 Myd88 Myd88 I79_013437 I79_013437 I79_013438 I79_013438 I79_013440 I79_013440 Ppard Ppard I79_013660 I79_013660 Pdgfrb Pdgfrb Irak1 Irak1 Gper1 Gper1 I79_014940 I79_014940 PPARG PPARG Htr1b Htr1b I79_015109 I79_015109 Sod2 Sod2 Ppargc1a Ppargc1a Adipoq Adipoq Pdgfd Pdgfd Hdac4 Hdac4 Hif1a Hif1a Ralbp1 Ralbp1 Frs2 Frs2 Ager Ager I79_016423 I79_016423 Aif1 Aif1 Tnf Tnf Ddx39b Ddx39b H671_1g1119 H671_1g1119 I79_016952 I79_016952 Tlr4 Tlr4 Pik3ca Pik3ca Efemp2 Efemp2 I79_017613 I79_017613 Pdgfb Pdgfb I79_017780 I79_017780 Drd4 Drd4 Adamts1 Adamts1 Foxj2 Foxj2 C3ar1 C3ar1 I79_018586 I79_018586 I79_018848 I79_018848 Sf1 Sf1 Npy5r Npy5r Pdcd4 Pdcd4 Ptk2 Ptk2 I79_019439 I79_019439 Ccdc142 Ccdc142 Znf143 Znf143 Ccl5 Ccl5 Stat1 Stat1 Tgfb1 Tgfb1 Klf4 Klf4 Hmox1 Hmox1 I79_020783 I79_020783 Irak4 Irak4 I79_021045 I79_021045 Ereg Ereg Mtor Mtor Nqo2 Nqo2 Jak2 Jak2 I79_022301 I79_022301 P2ry6 P2ry6 I79_022685 I79_022685 S1pr1 S1pr1 Mfn2 Mfn2 Tcf7l2 Tcf7l2 H671_1g2246 H671_1g2246 Xrcc6 Xrcc6 Fgfr2 Fgfr2 I79_024172 I79_024172 Ctnnbip1 Ctnnbip1 I79_024415 I79_024415 I79_024481 I79_024481 I79_024526 I79_024526 I79_024807 I79_024807 Pak1 Pak1 Nppc Nppc I79_025454 I79_025454 I79_025549 I79_025549 I79_025570 I79_025570 I79_025672 I79_025672 Smpd3 Smpd3 Trib1 Trib1 Myc Myc I79_025858 I79_025858 Dbh Dbh Tert Tert I79_025994 I79_025994 I79_026218 I79_026218 I79_026256 I79_026256 GNAI3 GNAI3 I79_011711 I79_011711 I79_011333 I79_011333 Igf1r Igf1r Cdkn1a Cdkn1a Skp2 Skp2 Phb Phb Rps6kb1 Rps6kb1 Il15 Il15 Npr3 Npr3 Cx3cl1 Cx3cl1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Thbs1Thrombospondin-1. (533 aa)
H671_xg20748Angiotensin-converting enzyme. (644 aa)
I79_009953Transcription factor AP-1. (72 aa)
Akr1b1Aldose reductase. (316 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
Mef2dMyocyte-specific enhancer factor 2D. (505 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
ElaneNeutrophil elastase; Belongs to the peptidase S1 family. (252 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
Shc1SHC-transforming protein 1. (579 aa)
I79_008058Guanylate cyclase. (813 aa)
Il6rInterleukin-6 receptor subunit alpha. (505 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
Il10Interleukin-10. (178 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Ctnnb1Catenin beta-1. (781 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Gnai2Guanine nucleotide-binding protein G(I), alpha-2 subunit. (338 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
I79_006462cGMP-dependent protein kinase 1, beta isozyme; Belongs to the protein kinase superfamily. (227 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
I79_005895DNA (Cytosine-5)-methyltransferase 1. (85 aa)
Dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1494 aa)
S1pr2Sphingosine 1-phosphate receptor 2. (352 aa)
Cnn1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
I79_005841Calponin-1. (79 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005745NADPH oxidase 1. (395 aa)
I79_005379Tropomyosin alpha-1 chain; Belongs to the tropomyosin family. (158 aa)
I79_005358Estrogen receptor beta. (58 aa)
Gna12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
Orc1Origin recognition complex subunit 1. (817 aa)
Tnfaip3Tumor necrosis factor, alpha-induced protein 3. (776 aa)
I79_002099Vascular endothelial growth factor receptor 1. (115 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
SrcTyrosine-protein kinase. (536 aa)
Alox12Arachidonate 12-lipoxygenase, 12S-type. (553 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
I79_003100Myocardin. (371 aa)
Edn1Endothelin-1. (202 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
Mmp272 kDa type IV collagenase. (662 aa)
PtafrPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
I79_004452Prohibitin. (131 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
ilkIntegrin-linked protein kinase. (452 aa)
I79_000233Cytochrome b-245 light chain. (206 aa)
Cdh13Cadherin-13. (377 aa)
Foxp1Forkhead box protein P1. (696 aa)
I79_001046Neurofibromin. (2164 aa)
VipVIP peptides. (170 aa)
Pde4dPhosphodiesterase. (507 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
I79_011804Neurogenic locus notch-like protein 3. (2181 aa)
ApoeApolipoprotein E. (313 aa)
Rgs5Regulator of G-protein signaling 5. (215 aa)
Ddr2Discoidin domain-containing receptor 2. (854 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
I79_013437Nuclear receptor subfamily 4 group A member 3. (598 aa)
I79_013438Prohibitin. (132 aa)
I79_013440Calcitonin gene-related peptide type 1 receptor. (426 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
I79_013660Beta-type platelet-derived growth factor receptor. (454 aa)
PdgfrbBeta-type platelet-derived growth factor receptor. (528 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (494 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
I79_014940Prohibitin. (85 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Htr1b5-hydroxytryptamine receptor 1B. (386 aa)
I79_015109Interleukin-6. (174 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
AdipoqAdiponectin. (248 aa)
PdgfdPlatelet-derived growth factor D. (253 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
Ralbp1RalA-binding protein 1. (643 aa)
Frs2Fibroblast growth factor receptor substrate 2. (509 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
Aif1Allograft inflammatory factor 1. (80 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Ddx39bSpliceosome RNA helicase BAT1. (288 aa)
H671_1g111915-hydroxyprostaglandin dehydrogenase [NAD+]-like protein. (208 aa)
I79_016952Nicotinamide phosphoribosyltransferase. (401 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
Efemp2EGF-containing fibulin-like extracellular matrix protein 2. (375 aa)
I79_017613DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3486 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
I79_017780Extracellular sulfatase Sulf-1. (787 aa)
Drd4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
Adamts1A disintegrin and metalloproteinase with thrombospondin motifs 1. (705 aa)
Foxj2Forkhead box protein J2. (573 aa)
C3ar1C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
I79_018586Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
I79_018848Prostacyclin receptor. (229 aa)
Sf1Splicing factor 1. (522 aa)
Npy5rNeuropeptide Y receptor type 5-like protein. (466 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
I79_019439Vasoactive intestinal polypeptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (303 aa)
Ccdc142Coiled-coil domain-containing protein 142. (723 aa)
Znf143Zinc finger protein 143. (618 aa)
Ccl5C-C motif chemokine. (91 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Klf4Krueppel-like factor 4. (474 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (462 aa)
I79_021045Heme oxygenase 1. (81 aa)
EregProepiregulin. (162 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
Nqo2Ribosyldihydronicotinamide dehydrogenase [quinone]. (231 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_022301Calcium/calmodulin-dependent protein kinase type II delta chain. (225 aa)
P2ry6p2Y purinoceptor 6. (328 aa)
I79_022685Dopamine beta-hydroxylase. (534 aa)
S1pr1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
H671_1g2246Protein NDRG2-like isoform 2. (328 aa)
Xrcc6ATP-dependent DNA helicase 2 subunit 1. (608 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_024172Aldose reductase. (150 aa)
Ctnnbip1Beta-catenin-interacting protein 1. (81 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
I79_024481Prohibitin. (274 aa)
I79_024526Alpha-2-antiplasmin; Belongs to the serpin family. (442 aa)
I79_024807Protein FAM19A5. (87 aa)
Pak1Serine/threonine-protein kinase PAK 1. (325 aa)
NppcC-type natriuretic peptide. (126 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
I79_025549WNT1-inducible-signaling pathway protein 1. (274 aa)
I79_025570Spliceosome RNA helicase Bat1. (229 aa)
I79_025672Spliceosome RNA helicase BAT1. (155 aa)
Smpd3Sphingomyelin phosphodiesterase 3. (446 aa)
Trib1Tribbles-like 1. (286 aa)
MycMyc proto-oncogene protein. (281 aa)
I79_025858Spliceosome RNA helicase BAT1. (66 aa)
DbhDopamine beta-hydroxylase. (117 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
I79_025994WNT1-inducible-signaling pathway protein 1. (136 aa)
I79_026218Calcium/calmodulin-dependent protein kinase type II delta chain. (64 aa)
I79_026256Spliceosome RNA helicase Bat1. (103 aa)
GNAI3Guanine nucleotide binding protein alpha inhibiting 3. (354 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
I79_011333Sphingomyelin phosphodiesterase 3. (410 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
Skp2S-phase kinase-associated protein 2. (424 aa)
PhbProhibitin. (272 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Npr3Atrial natriuretic peptide clearance receptor. (387 aa)
Cx3cl1Fractalkine. (335 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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