STRINGSTRING
Xbp1 Xbp1 Ccnd1 Ccnd1 Hlx Hlx Prox1 Prox1 I79_000120 I79_000120 I79_000233 I79_000233 Cdh13 Cdh13 Wnt7a Wnt7a Foxp1 Foxp1 Cldn1 Cldn1 Tp63 Tp63 I79_000899 I79_000899 I79_000973 I79_000973 I79_001046 I79_001046 CgPICR_003438 CgPICR_003438 I79_001073 I79_001073 Vip Vip Ccnd2 Ccnd2 Wnt5a Wnt5a Mmp12 Mmp12 I79_001484 I79_001484 I79_001513 I79_001513 Foxp2 Foxp2 Tnfaip3 Tnfaip3 I79_002251 I79_002251 Vhl Vhl Ghrl Ghrl Rptor Rptor Ppp1r16b Ppp1r16b I79_002659 I79_002659 Mdk Mdk Bmpr2 Bmpr2 Fzd7 Fzd7 Pdcd6 Pdcd6 Smo Smo Tacr1 Tacr1 Nog Nog Znf703 Znf703 I79_004031 I79_004031 Kif3a Kif3a Il18 Il18 Ecm1 Ecm1 I79_004631 I79_004631 I79_004653 I79_004653 Akt1 Akt1 Kdm5b Kdm5b I79_005201 I79_005201 I79_005202 I79_005202 I79_005331 I79_005331 Nod2 Nod2 Med1 Med1 Igf1 Igf1 Ghsr Ghsr Nodal Nodal Cxadr Cxadr I79_006225 I79_006225 I79_006254 I79_006254 Tgfbr1 Tgfbr1 Sema5a Sema5a I79_006650 I79_006650 Mst1 Mst1 I79_006679 I79_006679 Skor1 Skor1 Ctnnb1 Ctnnb1 Cav2 Cav2 Cav1 Cav1 Wnt2 Wnt2 I79_007089 I79_007089 I79_007090 I79_007090 I79_007135 I79_007135 Ptn Ptn Sirt1 Sirt1 Il10 Il10 CgPICR_020542 CgPICR_020542 Dlx5 Dlx5 Runx2 Runx2 I79_008095 I79_008095 I79_008174 I79_008174 Mydgf Mydgf Rreb1 Rreb1 Bmp6 Bmp6 Srsf6 Srsf6 Osr1 Osr1 I79_008633 I79_008633 Id1 Id1 I79_008941 I79_008941 Fgf1 Fgf1 I79_009030 I79_009030 Pgf Pgf Glul Glul Iqgap3 Iqgap3 Itgb3 Itgb3 Vegfc Vegfc I79_009837 I79_009837 Hrh3 Hrh3 I79_009904 I79_009904 I79_009953 I79_009953 Sfrp1 Sfrp1 Pdcl3 Pdcl3 I79_010136 I79_010136 I79_010279 I79_010279 Gata2 Gata2 Cdc42 Cdc42 I79_010923 I79_010923 Rtn4 Rtn4 Fgfr3 Fgfr3 I79_011284 I79_011284 Cdc25a Cdc25a Cdh3 Cdh3 Esrp2 Esrp2 Glul-2 Glul-2 Grn Grn I79_011641 I79_011641 Stat3 Stat3 Jcad Jcad Atp7a Atp7a I79_012556 I79_012556 Notch2 Notch2 I79_012727 I79_012727 I79_013066 I79_013066 I79_013214 I79_013214 Wdr48 Wdr48 I79_013437 I79_013437 Aplnr Aplnr I79_013817 I79_013817 I79_013970 I79_013970 Cflar Cflar Crnn Crnn Sp1 Sp1 I79_015109 I79_015109 Agap2 Agap2 I79_015223 I79_015223 Ihh Ihh Plcg1 Plcg1 Ccr3 Ccr3 Dab2ip Dab2ip I79_015624 I79_015624 I79_015916 I79_015916 Akt3 Akt3 I79_016362 I79_016362 Dicer1 Dicer1 Tnf Tnf Nol3 Nol3 Agtr1 Agtr1 I79_017040 I79_017040 Pkhd1 Pkhd1 I79_017230 I79_017230 Pdgfb Pdgfb Kctd5 Kctd5 Bnc1 Bnc1 I79_017795 I79_017795 Hras Hras Azin1 Azin1 Emc10 Emc10 I79_018849 I79_018849 Hmx2 Hmx2 Tgfa Tgfa Cxcl12 Cxcl12 I79_019286 I79_019286 Pik3cd Pik3cd I79_019663 I79_019663 I79_019695 I79_019695 Vegfb Vegfb Ccl5 Ccl5 B4galt1 B4galt1 Tgfb1 Tgfb1 Hmox1 Hmox1 Fgf7 Fgf7 I79_020783 I79_020783 I79_020968 I79_020968 I79_020969 I79_020969 I79_020974 I79_020974 I79_021045 I79_021045 I79_021125 I79_021125 I79_021155 I79_021155 Acvrl1 Acvrl1 Scg2 Scg2 I79_021564 I79_021564 I79_022023 I79_022023 I79_022034 I79_022034 Mtor Mtor Gpbar1 Gpbar1 I79_022645 I79_022645 Ar Ar I79_023112 I79_023112 I79_023183 I79_023183 I79_023268 I79_023268 I79_023502 I79_023502 Tcf7l2 Tcf7l2 I79_023773 I79_023773 Fgfr2 Fgfr2 I79_024292 I79_024292 Irs2 Irs2 I79_024391 I79_024391 I79_024657 I79_024657 I79_024744 I79_024744 Fgfbp1 Fgfbp1 I79_025437 I79_025437 I79_025441 I79_025441 Myc Myc Has2 Has2 I79_025933 I79_025933 I79_025944 I79_025944
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Xbp1X-box binding protein 1 isoform 1. (330 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HlxH2.0-like homeobox protein. (374 aa)
Prox1Prospero homeobox protein 1. (738 aa)
I79_000120Bone morphogenetic protein 5. (260 aa)
I79_000233Cytochrome b-245 light chain. (206 aa)
Cdh13Cadherin-13. (377 aa)
Wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
Foxp1Forkhead box protein P1. (696 aa)
Cldn1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
Tp63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
I79_000899T-box transcription factor TBX18. (498 aa)
I79_000973Transcription factor SOX-10. (360 aa)
I79_001046Neurofibromin. (2164 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
I79_001073C-C motif chemokine. (72 aa)
VipVIP peptides. (170 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
Mmp12Macrophage metalloelastase. (464 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
I79_001513Early growth response protein 3. (333 aa)
Foxp2Forkhead box protein P2. (492 aa)
Tnfaip3Tumor necrosis factor, alpha-induced protein 3. (776 aa)
I79_002251Type-1 angiotensin II receptor. (117 aa)
VhlVon Hippel-Lindau disease tumor suppressor. (134 aa)
GhrlAppetite-regulating hormone. (100 aa)
RptorRegulatory-associated protein of mTOR. (1331 aa)
Ppp1r16bProtein phosphatase 1 regulatory inhibitor subunit 16B. (569 aa)
I79_002659High mobility group protein HMGI-C. (103 aa)
MdkMidkine. (160 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Fzd7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (438 aa)
Pdcd6Programmed cell death protein 6. (83 aa)
SmoSmoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
NogNoggin. (117 aa)
Znf703Zinc finger protein 703. (143 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
Kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (646 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Ecm1Extracellular matrix protein 1. (563 aa)
I79_004631Angiogenic factor with G patch and FHA domains 1. (667 aa)
I79_004653Inositol 1,4,5-trisphosphate receptor type 1. (2569 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Kdm5bLysine-specific demethylase 5B. (748 aa)
I79_005201Serine/threonine-protein kinase D1. (116 aa)
I79_005202Serine/threonine-protein kinase D1. (748 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
Igf1Insulin-like growth factor I. (75 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
NodalNodal. (309 aa)
CxadrCoxsackievirus and adenovirus receptor-like. (394 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
Sema5aSemaphorin-5A. (1046 aa)
I79_006650Hepatocyte growth factor-like protein. (93 aa)
Mst1Hepatocyte growth factor-like protein. (88 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Skor1Dual specificity mitogen-activated protein kinase kinase 5. (719 aa)
Ctnnb1Catenin beta-1. (781 aa)
Cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007135Homeobox protein Nkx-2.5. (223 aa)
PtnPleiotrophin. (168 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Il10Interleukin-10. (178 aa)
CgPICR_020542Nucleoside diphosphate kinase. (152 aa)
Dlx5Homeobox protein DLX-5. (289 aa)
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
I79_008095Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (213 aa)
I79_008174Leucine-rich alpha-2-glycoprotein. (117 aa)
MydgfUPF0556 protein C19orf10-like. (166 aa)
Rreb1Ras-responsive element-binding protein 1. (1748 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
Srsf6Splicing factor, arginine/serine-rich 6. (210 aa)
Osr1Protein odd-skipped-related 1. (266 aa)
I79_008633Integrin alpha-4; Belongs to the integrin alpha chain family. (441 aa)
Id1DNA-binding protein inhibitor ID-1. (157 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
I79_009030T-box transcription factor TBX1. (293 aa)
PgfPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
GlulGlutamine synthetase; Belongs to the glutamine synthetase family. (297 aa)
Iqgap3Ras GTPase-activating-like protein IQGAP3. (1633 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
I79_009837Rapamycin-insensitive companion of mTOR. (1308 aa)
Hrh3Histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
I79_009904Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Belongs to the glycosyltransferase 29 family. (225 aa)
I79_009953Transcription factor AP-1. (72 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Pdcl3Phosducin-like protein 3. (241 aa)
I79_010136Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
I79_010279Epithelial splicing regulatory protein 1. (677 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
Cdc42Cell division control protein 42-like. (191 aa)
I79_010923Reticulon. (68 aa)
Rtn4Reticulon-4. (806 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
I79_011284M-phase inducer phosphatase 1. (307 aa)
Cdc25aM-phase inducer phosphatase 1. (121 aa)
Cdh3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
Esrp2Epithelial splicing regulatory protein 2. (697 aa)
Glul-2Glutamine synthetase. (373 aa)
GrnGranulins. (592 aa)
I79_011641Lithostathine-2. (214 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
JcadUncharacterized protein KIAA1462. (954 aa)
Atp7aCopper-transporting ATPase 1. (1457 aa)
I79_012556Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1227 aa)
Notch2Neurogenic locus notch-like protein 2. (1521 aa)
I79_012727Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (441 aa)
I79_013066Dysferlin. (1296 aa)
I79_013214Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1929 aa)
Wdr48WD repeat-containing protein 48. (665 aa)
I79_013437Nuclear receptor subfamily 4 group A member 3. (598 aa)
AplnrApelin receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
I79_013817NAD-dependent deacetylase sirtuin-6. (334 aa)
I79_013970Plexin-B3. (1806 aa)
CflarCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (484 aa)
CrnnCornulin. (462 aa)
Sp1Transcription factor Sp1. (778 aa)
I79_015109Interleukin-6. (174 aa)
Agap2Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (829 aa)
I79_015223Neurogenic locus notch-like protein 2. (248 aa)
IhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
Plcg1Phosphoinositide phospholipase C. (1217 aa)
Ccr3Putative C-C chemokine receptor type 3-like protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Dab2ipDisabled-like 2-interacting protein. (1065 aa)
I79_015624Thrombospondin-4. (960 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
I79_016362Vasohibin-2. (477 aa)
Dicer1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Nol3Heat shock factor protein 4; Belongs to the HSF family. (915 aa)
Agtr1Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
I79_017040C5a anaphylatoxin chemotactic receptor C5L2. (254 aa)
Pkhd1Fibrocystin. (176 aa)
I79_017230Fibrocystin. (1423 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Kctd53-phosphoinositide-dependent protein kinase 1; Belongs to the peptidase S1 family. (799 aa)
Bnc1Zinc finger protein basonuclin-1. (834 aa)
I79_017795Zinc finger protein basonuclin-1. (76 aa)
HrasGTPase HRas-like protein. (189 aa)
Azin1Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (447 aa)
Emc10UPF0510 protein INM02. (222 aa)
I79_018849Serine/threonine-protein kinase D2. (513 aa)
Hmx2Homeobox protein HMX2. (316 aa)
TgfaProtransforming growth factor alpha. (211 aa)
Cxcl12Stromal cell-derived factor 1. (89 aa)
I79_019286Androgen receptor. (295 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
I79_01966325-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (216 aa)
I79_019695Fibrocystin. (1076 aa)
VegfbVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
Ccl5C-C motif chemokine. (91 aa)
B4galt1Beta-1,4-galactosyltransferase 1. (258 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
I79_020968Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
I79_020969Fibroblast growth factor 18. (85 aa)
I79_020974Serine protease HTRA1. (268 aa)
I79_021045Heme oxygenase 1. (81 aa)
I79_021125Epigen. (135 aa)
I79_021155Paired box protein Pax-2. (503 aa)
Acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (776 aa)
Scg2Secretogranin-2. (763 aa)
I79_021564Pro-epidermal growth factor. (699 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
I79_022034Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
Gpbar1G-protein coupled bile acid receptor 1. (316 aa)
I79_022645Programmed cell death protein 6. (224 aa)
ArAndrogen receptor. (517 aa)
I79_023112Glutamine synthetase; Belongs to the glutamine synthetase family. (130 aa)
I79_023183Zinc finger protein 304. (368 aa)
I79_023268Disintegrin and metalloproteinase domain-containing protein 17. (527 aa)
I79_023502Protein SAAL1. (150 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
I79_023773Nuclear receptor subfamily 4 group A member 1. (924 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_024292EGF-like domain-containing protein 7. (238 aa)
Irs2Insulin receptor substrate 2. (465 aa)
I79_024391Protein SAAL1. (214 aa)
I79_024657Odontogenic ameloblast-associated protein. (300 aa)
I79_0247445-hydroxytryptamine receptor 2B. (407 aa)
Fgfbp1Fibroblast growth factor-binding protein 1. (248 aa)
I79_025437Junctional adhesion molecule-like. (340 aa)
I79_025441Receptor-type tyrosine-protein phosphatase-like N. (761 aa)
MycMyc proto-oncogene protein. (281 aa)
Has2Hyaluronan synthase 2. (337 aa)
I79_025933Programmed cell death protein 6. (60 aa)
I79_025944Hyaluronan synthase 2. (151 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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