STRINGSTRING
Il21 Il21 Nrg1 Nrg1 I79_014451 I79_014451 I79_014534 I79_014534 I79_014935 I79_014935 I79_014973 I79_014973 I79_015109 I79_015109 I79_015356 I79_015356 I79_015503 I79_015503 I79_015624 I79_015624 I79_001015 I79_001015 Plpp3 Plpp3 I79_000675 I79_000675 Parp14 Parp14 Tnk2 Tnk2 Pak2 Pak2 Plcg2 Plcg2 Npm3 Npm3 Cd81 Cd81 I79_015916 I79_015916 Adipoq Adipoq I79_016287 I79_016287 Itgb1 Itgb1 Nrp1 Nrp1 Tnf Tnf Lif Lif Osm Osm Tlr4 Tlr4 Dlg3 Dlg3 Cd80 Cd80 Lyn Lyn I79_017561 I79_017561 Pdgfb Pdgfb I79_018131 I79_018131 Htr2a Htr2a Clcf1 Clcf1 Agrn Agrn I79_018306 I79_018306 Clec6a Clec6a I79_018661 I79_018661 Epo Epo Itga5 Itga5 Tgfa Tgfa I79_019149 I79_019149 Adra2a Adra2a I79_019278 I79_019278 I79_019429 I79_019429 I79_019537 I79_019537 Gas6 Gas6 Vegfb Vegfb Ccl5 Ccl5 I79_020343 I79_020343 I79_020344 I79_020344 Nox4 Nox4 Tgfb1 Tgfb1 Fgf7 Fgf7 I79_020752 I79_020752 I79_021125 I79_021125 Ereg Ereg Areg Areg I79_021283 I79_021283 I79_021300 I79_021300 I79_021301 I79_021301 I79_021564 I79_021564 Grem1 Grem1 Ghr Ghr Gfra1 Gfra1 I79_021804 I79_021804 Efna5 Efna5 Mtor Mtor Jak2 Jak2 Iqgap1 Iqgap1 Yes1 Yes1 Tnfrsf14 Tnfrsf14 I79_023268 I79_023268 Osbp Osbp Cntf Cntf Unc119 Unc119 I79_024249 I79_024249 Afap1l2 Afap1l2 Pdgfra Pdgfra I79_024691 I79_024691 Kit Kit I79_025305 I79_025305 Hpx Hpx Csf3 Csf3 I79_025798 I79_025798 ICAM1 ICAM1 Ptprj Ptprj I79_002785 I79_002785 Dlg4 Dlg4 Phf23 Phf23 Src Src Ghrl Ghrl Agt Agt I79_002032 I79_002032 Cd4 Cd4 Tnfrsf1a Tnfrsf1a Ntf3 Ntf3 Vtn Vtn Tal1 Tal1 Lep Lep H671_5g13848 H671_5g13848 Cspg4 Cspg4 Ehd4 Ehd4 Isl1 Isl1 I79_004244 I79_004244 Il18 Il18 Adora1 Adora1 Prnp Prnp Crlf1 Crlf1 I79_005331 I79_005331 Csf2 Csf2 Lrrk1 Lrrk1 I79_005488 I79_005488 Nod2 Nod2 I79_005696 I79_005696 Igf1 Igf1 Angpt4 Angpt4 Cd40 Cd40 Lck Lck Cck Cck Cav2 Cav2 I79_007089 I79_007089 I79_007090 I79_007090 I79_007340 I79_007340 Il34 Il34 I79_007462 I79_007462 I79_007548 I79_007548 Mlst8 Mlst8 Il6r Il6r Hax1 Hax1 Efna1 Efna1 I79_008095 I79_008095 I79_008304 I79_008304 Fbxw9 Fbxw9 Bmp6 Bmp6 IL12B IL12B Dgkq Dgkq I79_008941 I79_008941 Ptpn1 Ptpn1 Adnp Adnp Arhgef2 Arhgef2 Itgb3 Itgb3 I79_009837 I79_009837 I79_010073 I79_010073 I79_010136 I79_010136 Acvr1 Acvr1 Hdac2 Hdac2 Il6st Il6st I79_010234 I79_010234 Plpp1 Plpp1 Syk Syk H671_3g8622 H671_3g8622 Kitlg Kitlg Il15 Il15 Ngf Ngf Gdnf Gdnf Fgfr3 Fgfr3 Ncf1 Ncf1 I79_011940 I79_011940 Ptprz1 Ptprz1 Fyn Fyn Gata1 Gata1 I79_012336 I79_012336 Adra1a Adra1a I79_012384 I79_012384 Ripk2 Ripk2 I79_012764 I79_012764 Hgf Hgf I79_013004 I79_013004 Spata46 Spata46 Ctnnd1 Ctnnd1 Ikzf4 Ikzf4 Il23a Il23a I79_013659 I79_013659 Cd74 Cd74 Nedd9 Nedd9 I79_014053 I79_014053 IL2 IL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Il21Interleukin-21. (67 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform. (259 aa)
I79_014451Pro-neuregulin-1, membrane-bound isoform. (639 aa)
I79_014534Muscle, skeletal receptor tyrosine protein kinase. (822 aa)
I79_014935Chondroitin sulfate proteoglycan 4. (849 aa)
I79_014973Pro-neuregulin-2, membrane-bound isoform. (386 aa)
I79_015109Interleukin-6. (174 aa)
I79_015356Heat shock factor protein 1. (524 aa)
I79_015503Transcription factor HES-1. (92 aa)
I79_015624Thrombospondin-4. (960 aa)
I79_001015Low-density lipoprotein receptor-related protein 8. (764 aa)
Plpp3Lipid phosphate phosphohydrolase 3. (312 aa)
I79_000675Poly [ADP-ribose] polymerase 9. (337 aa)
Parp14Poly [ADP-ribose] polymerase. (1786 aa)
Tnk2Activated CDC42 kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1040 aa)
Pak2Non-specific serine/threonine protein kinase. (524 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
Cd81Tetraspanin. (236 aa)
I79_015916Insulin-like growth factor II. (155 aa)
AdipoqAdiponectin. (248 aa)
I79_016287Testis-expressed protein 101. (448 aa)
Itgb1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (923 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
OsmOncostatin-M. (222 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Dlg3Disks large-like 3; Belongs to the MAGUK family. (868 aa)
Cd80T-lymphocyte activation antigen CD80. (177 aa)
LynTyrosine-protein kinase. (289 aa)
I79_017561Tyrosine-protein kinase Lyn. (101 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
I79_0181315-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (237 aa)
Htr2a5-hydroxytryptamine receptor 2A. (264 aa)
Clcf1Cardiotrophin-like cytokine factor 1. (225 aa)
AgrnAgrin. (2036 aa)
I79_018306Ephrin type-A receptor 4. (932 aa)
Clec6aC-type lectin domain family 6 member A. (167 aa)
I79_018661Metabotropic glutamate receptor 5. (275 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (729 aa)
TgfaProtransforming growth factor alpha. (211 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
I79_019278B-cell scaffold protein with ankyrin repeats. (659 aa)
I79_019429Contactin-1. (461 aa)
I79_019537Metabotropic glutamate receptor 5. (297 aa)
Gas6Growth arrest-specific protein 6. (684 aa)
VegfbVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
Ccl5C-C motif chemokine. (91 aa)
I79_020343Cardiotrophin-2. (229 aa)
I79_020344Cardiotrophin-1. (203 aa)
Nox4NADPH oxidase 4. (130 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
I79_020752Chondroitin sulfate proteoglycan 4. (1364 aa)
I79_021125Epigen. (135 aa)
EregProepiregulin. (162 aa)
AregAmphiregulin. (230 aa)
I79_021283Angiopoietin-1. (298 aa)
I79_021300Poly [ADP-ribose] polymerase. (324 aa)
I79_021301Poly [ADP-ribose] polymerase 9. (112 aa)
I79_021564Pro-epidermal growth factor. (699 aa)
Grem1Gremlin-1. (117 aa)
GhrGrowth hormone receptor. (345 aa)
Gfra1GDNF family receptor alpha-1. (284 aa)
I79_021804GDNF family receptor alpha-1. (133 aa)
Efna5Ephrin-A5; Belongs to the ephrin family. (172 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
Iqgap1Ras GTPase-activating-like protein IQGAP1. (1675 aa)
Yes1Tyrosine-protein kinase. (541 aa)
Tnfrsf14Tumor necrosis factor receptor superfamily member 14. (184 aa)
I79_023268Disintegrin and metalloproteinase domain-containing protein 17. (527 aa)
OsbpOxysterol-binding protein; Belongs to the OSBP family. (736 aa)
CntfCiliary neurotrophic factor. (59 aa)
Unc119Protein unc-119-like A. (80 aa)
I79_024249Poly [ADP-ribose] polymerase 9. (106 aa)
Afap1l2Actin filament-associated protein 1-like 2. (826 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
I79_024691Poly [ADP-ribose] polymerase 9. (187 aa)
KitMast/stem cell growth factor receptor. (452 aa)
I79_025305UPF0389 protein FAM162A. (213 aa)
HpxHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (461 aa)
Csf3Granulocyte colony-stimulating factor. (208 aa)
I79_025798Vitronectin. (230 aa)
ICAM1Intercellular adhesion molecule 1. (527 aa)
PtprjReceptor-type tyrosine-protein phosphatase eta. (1077 aa)
I79_002785Beta-arrestin-2. (65 aa)
Dlg4Disks large-like 4. (216 aa)
Phf23Segment polarity protein dishevelled-like DVL-2. (697 aa)
SrcTyrosine-protein kinase. (536 aa)
GhrlAppetite-regulating hormone. (100 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
I79_002032Protein Dok-7. (453 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Tnfrsf1aTumor necrosis factor receptor superfamily member 1A. (355 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
VtnVitronectin. (876 aa)
Tal1T-cell acute lymphocytic leukemia protein 1-like. (329 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
H671_5g13848Interleukin-24-like protein. (160 aa)
Cspg4Chondroitin sulfate proteoglycan 4. (2323 aa)
Ehd4EH domain-containing protein 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (628 aa)
Isl1Insulin gene enhancer protein ISL-1. (257 aa)
I79_004244Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
PrnpMajor prion protein; Belongs to the prion family. (254 aa)
Crlf1Cytokine receptor-like factor 1. (382 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (95 aa)
Lrrk1Leucine-rich repeat serine/threonine-protein kinase 1. (396 aa)
I79_005488Progesterone-induced-blocking factor 1. (757 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
I79_005696p130Cas-associated protein. (1144 aa)
Igf1Insulin-like growth factor I. (75 aa)
Angpt4Angiopoietin-4. (499 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
LckProto-oncogene tyrosine-protein kinase LCK. (158 aa)
CckCholecystokinin. (115 aa)
Cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007340Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (592 aa)
Il34Interleukin-34. (201 aa)
I79_007462Poly [ADP-ribose] polymerase 14. (125 aa)
I79_007548Angiopoietin-1. (112 aa)
Mlst8Target of rapamycin complex subunit LST8. (326 aa)
Il6rInterleukin-6 receptor subunit alpha. (505 aa)
Hax1HCLS1-associated protein X-1. (105 aa)
Efna1Ephrin-A1; Belongs to the ephrin family. (205 aa)
I79_008095Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (213 aa)
I79_008304Platelet endothelial cell adhesion molecule. (596 aa)
Fbxw9F-box/WD repeat-containing protein 9. (458 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
DgkqDiacylglycerol kinase. (491 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
AdnpActivity-dependent neuroprotector homeobox protein. (1102 aa)
Arhgef2Rho guanine nucleotide exchange factor 2. (1031 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
I79_009837Rapamycin-insensitive companion of mTOR. (1308 aa)
I79_010073Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
I79_010136Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
Acvr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
I79_010234Interleukin-31 receptor A. (530 aa)
Plpp1Lipid phosphate phosphohydrolase 1. (235 aa)
SykTyrosine-protein kinase. (611 aa)
H671_3g8622Semaphorin-4D; Belongs to the semaphorin family. (833 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
NgfBeta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
GdnfGlial cell line-derived neurotrophic factor. (160 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
Ncf1Neutrophil cytosol factor 1. (303 aa)
I79_011940Platelet glycoprotein 4; Belongs to the CD36 family. (348 aa)
Ptprz1Receptor-type tyrosine-protein phosphatase zeta. (2289 aa)
FynProto-oncogene tyrosine-protein kinase Fyn. (232 aa)
Gata1Erythroid transcription factor-like protein. (330 aa)
I79_012336Protein tyrosine kinase 2 beta. (53 aa)
Adra1aAlpha-1A adrenergic receptor. (465 aa)
I79_012384Leukocyte common antigen. (962 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
I79_012764Ras GTPase-activating protein 1. (826 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
I79_013004F-box/WD repeat-containing protein 7. (709 aa)
Spata46Uncharacterized protein C1orf111-like. (290 aa)
Ctnnd1Catenin delta-1. (932 aa)
Ikzf4Receptor protein-tyrosine kinase. (1902 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
I79_013659Macrophage colony-stimulating factor 1 receptor. (595 aa)
Cd74H-2 class II histocompatibility antigen gamma chain. (329 aa)
Nedd9Enhancer of filamentation 1. (830 aa)
I79_014053Abl interactor 1. (280 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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