STRINGSTRING
Il18 Il18 Parp14 Parp14 I79_000959 I79_000959 Ntf3 Ntf3 Ptpn6 Ptpn6 Prkcd Prkcd Socs1 Socs1 Dusp22 Dusp22 Chmp6 Chmp6 Sh2b3 Sh2b3 Thy1 Thy1 I79_022952 I79_022952 H671_2g4697 H671_2g4697 I79_022335 I79_022335 Errfi1 Errfi1 I79_021300 I79_021300 I79_020948 I79_020948 Inpp5f Inpp5f Socs5 Socs5 I79_019855 I79_019855 Mvp Mvp I79_018310 I79_018310 I79_017398 I79_017398 I79_017397 I79_017397 Hnf4a Hnf4a Zfyve28 Zfyve28 I79_016131 I79_016131 H671_4g12667 H671_4g12667 Psen2 Psen2 Ncapg2 Ncapg2 I79_014319 I79_014319 Cblb Cblb Nf2 Nf2 I79_012384 I79_012384 Psen1 Psen1 Vps25 Vps25 Rack1 Rack1 H671_3g8622 H671_3g8622 Sfrp1 Sfrp1 Zgpat Zgpat Ptk6 Ptk6 I79_008304 I79_008304 Gprc5a Gprc5a I79_007462 I79_007462 Cav1 Cav1 Ggnbp2 Ggnbp2 Hyal2 Hyal2 Socs4 Socs4 I79_006143 I79_006143 Igf1 Igf1 I79_005696 I79_005696 I79_005573 I79_005573 I79_005488 I79_005488 Lrrk1 Lrrk1 H671_4g12084 H671_4g12084 Socs3 Socs3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Parp14Poly [ADP-ribose] polymerase. (1786 aa)
I79_000959CMRF35-like molecule 8. (295 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
Ptpn6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
PrkcdNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
Socs1Suppressor of cytokine signaling 1. (93 aa)
Dusp22Dual specificity protein phosphatase 22. (197 aa)
Chmp6Charged multivesicular body protein 6. (176 aa)
Sh2b3SH2B adapter protein 3. (364 aa)
Thy1Thy-1 membrane glycoprotein. (147 aa)
I79_022952SH3 domain-binding protein 5-like. (81 aa)
H671_2g4697SH3 domain-binding protein 5-like. (120 aa)
I79_022335SH3 domain-binding protein 5-like. (115 aa)
Errfi1ERBB receptor feedback inhibitor 1. (460 aa)
I79_021300Poly [ADP-ribose] polymerase. (324 aa)
I79_020948Interferon regulatory factor 1. (369 aa)
Inpp5fPhosphatidylinositide phosphatase SAC2. (842 aa)
Socs5Suppressor of cytokine signaling 5. (530 aa)
I79_019855SH3 domain-binding protein 5-like. (120 aa)
MvpMajor vault protein. (861 aa)
I79_018310FGFR1 oncogene partner. (281 aa)
I79_017398Protein kinase C zeta type. (53 aa)
I79_017397Protein kinase C zeta type. (280 aa)
Hnf4aHepatocyte nuclear factor 4-alpha. (464 aa)
Zfyve28Lateral signaling target protein 2-like. (908 aa)
I79_016131Charged multivesicular body protein 6. (186 aa)
H671_4g12667Alpha-2-HS-glycoprotein. (333 aa)
Psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
Ncapg2Condensin-2 complex subunit G2. (533 aa)
I79_014319Condensin-2 complex subunit G2. (207 aa)
CblbE3 ubiquitin-protein ligase CBL-B. (984 aa)
Nf2Merlin-like protein. (596 aa)
I79_012384Leukocyte common antigen. (962 aa)
Psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
Vps25Vacuolar protein-sorting-associated protein 25. (176 aa)
Rack1Guanine nucleotide-binding protein subunit beta-2-like 1. (276 aa)
H671_3g8622Semaphorin-4D; Belongs to the semaphorin family. (833 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
ZgpatZinc finger CCCH-type with G patch domain-containing protein. (188 aa)
Ptk6Tyrosine-protein kinase. (450 aa)
I79_008304Platelet endothelial cell adhesion molecule. (596 aa)
Gprc5aRetinoic acid-induced protein 3. (354 aa)
I79_007462Poly [ADP-ribose] polymerase 14. (125 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Ggnbp2Gametogenetin-binding protein 2. (667 aa)
Hyal2Hyaluronidase. (359 aa)
Socs4Suppressor of cytokine signaling 4. (435 aa)
I79_006143Inhibitor of Bruton tyrosine kinase. (1086 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005696p130Cas-associated protein. (1144 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
I79_005488Progesterone-induced-blocking factor 1. (757 aa)
Lrrk1Leucine-rich repeat serine/threonine-protein kinase 1. (396 aa)
H671_4g12084SAM domain-containing protein SAMSN-1-like protein. (253 aa)
Socs3Suppressor of cytokine signaling 3. (225 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.