STRINGSTRING
Il1rl2 Il1rl2 Tyk2 Tyk2 Igf1 Igf1 Nck2 Nck2 I79_005603 I79_005603 I79_005503 I79_005503 Zbtb1 Zbtb1 Jak3 Jak3 I79_005129 I79_005129 Fcho1 Fcho1 I79_005113 I79_005113 Igfbp2 Igfbp2 Ap3b1 Ap3b1 I79_004486 I79_004486 Il18 Il18 I79_004087 I79_004087 I79_003972 I79_003972 Cd83 Cd83 I79_003362 I79_003362 Tnfsf4 Tnfsf4 Lep Lep Traf6 Traf6 Cd28 Cd28 Ambra1 Ambra1 I79_002696 I79_002696 Foxo3 Foxo3 Adk Adk Socs1 Socs1 Slc7a1 Slc7a1 I79_001990 I79_001990 I79_001680 I79_001680 Tgfbr2 Tgfbr2 I79_001513 I79_001513 Selenok Selenok Cd4 Cd4 CgPICR_003438 CgPICR_003438 I79_001029 I79_001029 I79_001024 I79_001024 Bcl6 Bcl6 Tfrc Tfrc Hlx Hlx Dusp10 Dusp10 I79_000010 I79_000010 Gata3 Gata3 Mdk Mdk I79_013190 I79_013190 I79_013191 I79_013191 Il23a Il23a Cd74 Cd74 I79_013189 I79_013189 I79_013188 I79_013188 I79_013183 I79_013183 I79_013182 I79_013182 I79_013180 I79_013180 H671_1g3220 H671_1g3220 I79_013013 I79_013013 Fadd Fadd Nfkbid Nfkbid Ripk2 Ripk2 Xbp1 Xbp1 Runx1 Runx1 H671_3g9571 H671_3g9571 I79_012384 I79_012384 Foxp3 Foxp3 Ccl19 Ccl19 Runx3 Runx3 I79_011712 I79_011712 I79_011711 I79_011711 Ada Ada Slc4a1 Slc4a1 I79_011406 I79_011406 Hspd1 Hspd1 I79_011202 I79_011202 I79_011181 I79_011181 Il15 Il15 Kitlg Kitlg I79_026231 I79_026231 I79_025915 I79_025915 Il12rb1 Il12rb1 I79_025726 I79_025726 I79_025535 I79_025535 I79_025518 I79_025518 I79_025497 I79_025497 I79_025496 I79_025496 I79_025433 I79_025433 Il36b Il36b Dock8 Dock8 I79_025274 I79_025274 Bcl10 Bcl10 I79_025214 I79_025214 I79_024975 I79_024975 Rhoh Rhoh I79_024695 I79_024695 I79_024694 I79_024694 I79_024693 I79_024693 Itgal Itgal I79_024407 I79_024407 I79_024097 I79_024097 I79_023818 I79_023818 Thy1 Thy1 I79_023533 I79_023533 I79_023475 I79_023475 I79_023244 I79_023244 I79_023002 I79_023002 Tnfrsf14 Tnfrsf14 Abl1 Abl1 Blm Blm I79_022515 I79_022515 I79_022300 I79_022300 Jak2 Jak2 I79_021950 I79_021950 Kat5 Kat5 Rps3 Rps3 Cd46 Cd46 Vcam1 Vcam1 Efnb1 Efnb1 I79_021151 I79_021151 Tnfrsf13c Tnfrsf13c I79_020920 I79_020920 I79_020917 I79_020917 I79_020697 I79_020697 Adam8 Adam8 Tgfb1 Tgfb1 Socs5 Socs5 Ccl5 Ccl5 Flot2 Flot2 CUNHXorf65 CUNHXorf65 I79_019425 I79_019425 Vnn1 Vnn1 I79_019300 I79_019300 Il4i1 Il4i1 Wnt10b Wnt10b I79_019042 I79_019042 I79_019038 I79_019038 I79_018994 I79_018994 I79_018993 I79_018993 Epo Epo CgPICR_011244 CgPICR_011244 Ccr7 Ccr7 I79_018785 I79_018785 Anxa1 Anxa1 Lgals1 Lgals1 I79_018349 I79_018349 Il4r Il4r I79_017833 I79_017833 Sart1 Sart1 I79_017540 I79_017540 I79_017450 I79_017450 Zbtb16 Zbtb16 Vsir Vsir I79_017398 I79_017398 I79_017397 I79_017397 Cd80 Cd80 H671_3g9603 H671_3g9603 IL1B IL1B I79_017160 I79_017160 Sirpa Sirpa Tespa1 Tespa1 I79_016618 I79_016618 I79_016534 I79_016534 Aif1 Aif1 I79_016423 I79_016423 Ager Ager I79_015916 I79_015916 Cd81 Cd81 I79_015503 I79_015503 CgPICR_014700 CgPICR_014700 Ihh Ihh Lgals8 Lgals8 Abl2 Abl2 I79_015109 I79_015109 Gli3 Gli3 Itpkb Itpkb IL2 IL2 Il21 Il21 I79_013907 I79_013907 Nfkbiz Nfkbiz Tnfsf11 Tnfsf11 I79_010003 I79_010003 Rasgrp1 Rasgrp1 Il6st Il6st Syk Syk Dnaja3 Dnaja3 Ap3d1 Ap3d1 Nck1 Nck1 Cd276 Cd276 I79_008828 I79_008828 IL12B IL12B Cd47 Cd47 H671_3g9841 H671_3g9841 Dhps Dhps Tnfsf14 Tnfsf14 Tnfsf9 Tnfsf9 Zbtb7b Zbtb7b Pck1 Pck1 I79_007699 I79_007699 Cd86 Cd86 Zp3 Zp3 Cav1 Cav1 Lck Lck Vtcn1 Vtcn1 I79_006517 I79_006517 I79_006470 I79_006470 Shb Shb I79_006225 I79_006225 I79_005999 I79_005999 I79_005968 I79_005968
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Il1rl2Interleukin-1 receptor-like 2. (190 aa)
Tyk2Tyrosine-protein kinase. (1182 aa)
Igf1Insulin-like growth factor I. (75 aa)
Nck2Cytoplasmic protein. (380 aa)
I79_005603Putative ubiquitin carboxyl-terminal hydrolase CYLD. (730 aa)
I79_005503Polycomb complex protein BMI-1. (324 aa)
Zbtb1Zinc finger and BTB domain-containing protein 1. (713 aa)
Jak3Tyrosine-protein kinase JAK3. (222 aa)
I79_005129Tyrosine-protein kinase JAK3. (330 aa)
Fcho1FCH domain only protein 1; Belongs to the adaptor complexes medium subunit family. (233 aa)
I79_005113Interleukin-12 receptor beta-1 chain. (585 aa)
Igfbp2Insulin-like growth factor-binding protein 2. (177 aa)
Ap3b1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1091 aa)
I79_004486CD160 antigen. (151 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
I79_004087Tyrosine-protein kinase. (593 aa)
I79_00397260 kDa heat shock protein, mitochondrial; Belongs to the TCP-1 chaperonin family. (104 aa)
Cd83CD83 antigen. (202 aa)
I79_003362Complement decay-accelerating factor. (157 aa)
Tnfsf4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
Cd28T-cell-specific surface glycoprotein CD28. (100 aa)
Ambra1Activating molecule in BECN1-regulated autophagy protein 1. (1300 aa)
I79_002696Phosphoinositide 3-kinase regulatory subunit 6. (395 aa)
Foxo3Forkhead box protein O3. (672 aa)
AdkAdenosine kinase. (361 aa)
Socs1Suppressor of cytokine signaling 1. (93 aa)
Slc7a1High affinity cationic amino acid transporter 1. (628 aa)
I79_001990Myb proto-oncogene protein. (650 aa)
I79_001680Caspase recruitment domain-containing protein 11. (1089 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
I79_001513Early growth response protein 3. (333 aa)
SelenokSelenoprotein K. (91 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
I79_001029Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (277 aa)
I79_001024Ephrin-B2; Belongs to the ephrin family. (373 aa)
Bcl6B-cell lymphoma 6 protein-like. (707 aa)
TfrcTransferrin receptor protein 1. (757 aa)
HlxH2.0-like homeobox protein. (374 aa)
Dusp10Dual specificity protein phosphatase 10. (482 aa)
I79_000010Protein kinase C. (566 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
MdkMidkine. (160 aa)
I79_013190Ig-like domain-containing protein; Belongs to the MHC class II family. (206 aa)
I79_013191HLA class II histocompatibility antigen, DR-1 beta chain. (503 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
Cd74H-2 class II histocompatibility antigen gamma chain. (329 aa)
I79_013189RT1 class II histocompatibility antigen, B-1 beta chain. (165 aa)
I79_013188HLA class II histocompatibility antigen, DO beta chain. (258 aa)
I79_013183Class II histocompatibility antigen, M beta 1 chain. (261 aa)
I79_013182Class II histocompatibility antigen, M alpha chain; Belongs to the MHC class II family. (261 aa)
I79_013180HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (523 aa)
H671_1g3220HLA class II histocompatibility antigen, DP beta 1 chain-like protein. (280 aa)
I79_013013Transcription factor SOX-13. (600 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
NfkbidNF-kappa-B inhibitor delta. (74 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
Xbp1X-box binding protein 1 isoform 1. (330 aa)
Runx1Runt-related transcription factor 1. (462 aa)
H671_3g9571Zona pellucida sperm-binding protein 4. (454 aa)
I79_012384Leukocyte common antigen. (962 aa)
Foxp3Forkhead box protein P3. (428 aa)
Ccl19C-C motif chemokine. (117 aa)
Runx3Runt-related transcription factor 3. (299 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
AdaAdenosine deaminase. (363 aa)
Slc4a1Anion exchange protein. (915 aa)
I79_011406Ephrin type-B receptor 6. (983 aa)
Hspd160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (526 aa)
I79_011202T-cell surface glycoprotein CD1d1. (111 aa)
I79_011181Interleukin-7 receptor subunit alpha. (257 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
I79_026231Ephrin-B2; Belongs to the ephrin family. (68 aa)
I79_025915Protein FAM49B. (58 aa)
Il12rb1Interleukin-12 receptor beta-1 chain. (183 aa)
I79_025726Ephrin-B2. (121 aa)
I79_025535Ephrin-B2. (125 aa)
I79_025518Ephrin-B2. (123 aa)
I79_025497Ephrin-B2; Belongs to the ephrin family. (69 aa)
I79_025496Ephrin-B2. (147 aa)
I79_025433Ephrin-B2; Belongs to the ephrin family. (70 aa)
Il36bInterleukin-1. (138 aa)
Dock8Dedicator of cytokinesis protein 8. (73 aa)
I79_025274Integrin alpha-L. (331 aa)
Bcl10B-cell lymphoma/leukemia 10. (232 aa)
I79_025214Signal-regulatory protein beta-1 isoform 3. (330 aa)
I79_024975Ephrin-B2. (148 aa)
RhohRho-related GTP-binding protein RhoH. (191 aa)
I79_024695Butyrophilin-like protein 2. (415 aa)
I79_024694Ig-like domain-containing protein; Belongs to the MHC class II family. (208 aa)
I79_024693H-2 class II histocompatibility antigen, I-A beta chain. (194 aa)
ItgalIntegrin alpha-L; Belongs to the integrin alpha chain family. (699 aa)
I79_02440760 kDa heat shock protein, mitochondrial. (214 aa)
I79_024097Vascular cell adhesion protein 1. (225 aa)
I79_023818Dedicator of cytokinesis protein 8; Belongs to the DOCK family. (1309 aa)
Thy1Thy-1 membrane glycoprotein. (147 aa)
I79_023533H-2 class II histocompatibility antigen, I-A beta chain. (125 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
I79_023244Bloom syndrome protein-like. (721 aa)
I79_023002Receptor protein-tyrosine kinase. (650 aa)
Tnfrsf14Tumor necrosis factor receptor superfamily member 14. (184 aa)
Abl1Tyrosine-protein kinase transforming protein Abl. (322 aa)
BlmATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (464 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
I79_02230060 kDa heat shock protein, mitochondrial. (252 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_021950T-cell differentiation antigen CD6. (536 aa)
Kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
Rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (117 aa)
Cd46Membrane cofactor protein. (280 aa)
Vcam1Vascular cell adhesion protein 1. (220 aa)
Efnb1Ephrin-B1; Belongs to the ephrin family. (343 aa)
I79_021151Ephrin-B2. (178 aa)
Tnfrsf13cTumor necrosis factor receptor superfamily member 13C. (162 aa)
I79_020920Tyrosine-protein phosphatase non-receptor type substrate 1. (251 aa)
I79_020917Tyrosine-protein phosphatase non-receptor type substrate 1. (377 aa)
I79_020697Glycerol-3-phosphate acyltransferase 1, mitochondrial. (980 aa)
Adam8Disintegrin and metalloproteinase domain-containing protein 8. (936 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Socs5Suppressor of cytokine signaling 5. (530 aa)
Ccl5C-C motif chemokine. (91 aa)
Flot2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
CUNHXorf65Cytokine receptor common gamma chain. (456 aa)
I79_019425Apoptosis-associated speck-like protein containing a CARD. (192 aa)
Vnn1Pantetheinase. (512 aa)
I79_019300L-amino-acid oxidase. (112 aa)
Il4i1L-amino-acid oxidase. (413 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
I79_01904260 kDa heat shock protein, mitochondrial. (169 aa)
I79_019038Nck-associated protein 1-like. (1065 aa)
I79_018994Interleukin-12 receptor beta-2 chain. (358 aa)
I79_018993Interleukin-23 receptor. (380 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
CgPICR_01124440S ribosomal protein S3. (94 aa)
Ccr7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
I79_018785Retinoic acid receptor alpha. (484 aa)
Anxa1Annexin. (346 aa)
Lgals1Galectin. (135 aa)
I79_018349Coronin-1A. (143 aa)
Il4rInterleukin-4 receptor alpha chain. (835 aa)
I79_017833Lymphoid enhancer-binding factor 1. (276 aa)
Sart1U4/U6.U5 tri-snRNP-associated protein 1. (1215 aa)
I79_017540Selenoprotein K. (100 aa)
I79_017450Zinc finger and BTB domain-containing protein 16. (236 aa)
Zbtb16Zinc finger and BTB domain-containing protein 16. (423 aa)
VsirPlatelet receptor Gi24. (271 aa)
I79_017398Protein kinase C zeta type. (53 aa)
I79_017397Protein kinase C zeta type. (280 aa)
Cd80T-lymphocyte activation antigen CD80. (177 aa)
H671_3g960360 kDa heat shock protein, mitochondrial. (141 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_017160Signal-regulatory protein beta-1 isoform 3. (414 aa)
SirpaTyrosine-protein phosphatase non-receptor type substrate 1. (522 aa)
Tespa1Uncharacterized protein KIAA0748-like. (496 aa)
I79_016618Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (470 aa)
I79_016534Leucine-rich repeat-containing protein 16C. (1178 aa)
Aif1Allograft inflammatory factor 1. (80 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Cd81Tetraspanin. (236 aa)
I79_015503Transcription factor HES-1. (92 aa)
CgPICR_014700C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
IhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
Lgals8Galectin. (316 aa)
Abl2Tyrosine-protein kinase. (1167 aa)
I79_015109Interleukin-6. (174 aa)
Gli3Zinc finger protein GLI3. (1582 aa)
ItpkbKinase; Belongs to the inositol phosphokinase (IPK) family. (789 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Il21Interleukin-21. (67 aa)
I79_013907Ephrin-B2. (148 aa)
NfkbizNF-kappa-B inhibitor zeta. (410 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
I79_010003Zinc finger MIZ domain-containing protein 1. (960 aa)
Rasgrp1RAS guanyl-releasing protein 1. (787 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
SykTyrosine-protein kinase. (611 aa)
Dnaja3DnaJ-like subfamily A member 3, mitochondrial. (453 aa)
Ap3d1AP-3 complex subunit delta-1. (1199 aa)
Nck1Cytoplasmic protein NCK1. (602 aa)
Cd276CD276 antigen. (316 aa)
I79_008828Lymphotactin. (114 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
Cd47Leukocyte surface antigen CD47. (268 aa)
H671_3g9841Interleukin-27 receptor subunit alpha. (566 aa)
DhpsDeoxyhypusine synthase-like isoform 1. (369 aa)
Tnfsf14Tumor necrosis factor ligand superfamily member 14. (238 aa)
Tnfsf9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (307 aa)
Zbtb7bZinc finger and BTB domain-containing protein 7B. (543 aa)
Pck1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
I79_007699GTPase IMAP family member 5. (344 aa)
Cd86T-lymphocyte activation antigen CD86. (269 aa)
Zp3Zona pellucida sperm-binding protein 3. (403 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
LckProto-oncogene tyrosine-protein kinase LCK. (158 aa)
Vtcn1V-set domain containing T-cell activation inhibitor 1. (206 aa)
I79_006517Spectrin alpha chain, erythrocyte. (181 aa)
I79_006470Natural killer cell receptor 2B4. (280 aa)
ShbSH2 domain-containing adapter protein B. (298 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_005999Spectrin alpha chain, erythrocyte. (326 aa)
I79_005968CD40 ligand; Belongs to the tumor necrosis factor family. (219 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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