(35 nodes) Brown fat cell differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_020576	Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (267 aa)
	Pex11a	Peroxisomal membrane protein 11A. (204 aa)
	Adrb2	Beta-2 adrenergic receptor. (337 aa)
	Fabp3	Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (121 aa)
	Bnip3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
	I79_024173	PR domain zinc finger protein 16. (77 aa)
	Mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	I79_025026	PR domain zinc finger protein 16. (409 aa)
	I79_025027	PR domain zinc finger protein 16. (86 aa)
	Prdm16	PR domain zinc finger protein 16. (274 aa)
	Mrap	Melanocortin-2 receptor accessory protein. (108 aa)
	I79_001272	Integrin alpha-6; Belongs to the integrin alpha chain family. (890 aa)
	Dhrs7b	Dehydrogenase/reductase SDR family member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
	Ptgs2	Prostaglandin G/H synthase 2. (604 aa)
	Slc2a4	Solute carrier family 2, facilitated glucose transporter member 4. (90 aa)
	I79_007707	Retinoic acid receptor responder protein 2. (144 aa)
	I79_007315	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (226 aa)
	I79_008174	Leucine-rich alpha-2-glycoprotein. (117 aa)
	I79_007282	SH2B adapter protein 2. (60 aa)
	Sh2b2	SH2B adapter protein 2. (363 aa)
	I79_006981	G-protein coupled receptor 120. (318 aa)
	I79_006925	Peroxisomal coenzyme A diphosphatase NUDT7. (177 aa)
	Rgs2	Regulator of G-protein signaling 2. (207 aa)
	Lamb3	Laminin subunit beta-3. (1166 aa)
	Arl4a	ADP-ribosylation factor-like protein 4A. (200 aa)
	Gata2	Endothelial transcription factor GATA-2. (480 aa)
	I79_010817	Laminin subunit alpha-4. (1743 aa)
	Aldh6a1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. (243 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Ebf2	Transcription factor COE2. (553 aa)
	Adipoq	Adiponectin. (248 aa)
	I79_016391	Acyl-CoA desaturase 1; Belongs to the fatty acid desaturase type 1 family. (254 aa)
	Fabp4	Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	Znf516	Zinc finger protein 516. (1148 aa)
	Plac8	Placenta-specific gene 8 protein. (112 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	Fabp4	G3HYG0	G3I4E8	Adiponectin.	Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.901
Adipoq	I79_007707	G3HYG0	G3HB86	Adiponectin.	Retinoic acid receptor responder protein 2.	0.432
Adipoq	I79_020576	G3HYG0	G3IAF5	Adiponectin.	Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.588
Adipoq	PPARG	G3HYG0	G3HVG0	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.885
Adipoq	Prdm16	G3HYG0	G3IMQ2	Adiponectin.	PR domain zinc finger protein 16.	0.463
Adipoq	Slc2a4	G3HYG0	G3GY97	Adiponectin.	Solute carrier family 2, facilitated glucose transporter member 4.	0.661
Bnip3	Mb	G3IFW8	G3ILQ5	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.410
Ebf2	PPARG	G3HY76	G3HVG0	Transcription factor COE2.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.663
Ebf2	Prdm16	G3HY76	G3IMQ2	Transcription factor COE2.	PR domain zinc finger protein 16.	0.586
Fabp3	Fabp4	G3H1W8	G3I4E8	Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.909
Fabp3	PPARG	G3H1W8	G3HVG0	Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.504
Fabp4	Adipoq	G3I4E8	G3HYG0	Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Adiponectin.	0.901
Fabp4	Fabp3	G3I4E8	G3H1W8	Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.909
Fabp4	PPARG	G3I4E8	G3HVG0	Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.844
I79_001272	I79_010817	G3GUB8	G3HJH2	Integrin alpha-6; Belongs to the integrin alpha chain family.	Laminin subunit alpha-4.	0.715
I79_001272	Lamb3	G3GUB8	G3H2M7	Integrin alpha-6; Belongs to the integrin alpha chain family.	Laminin subunit beta-3.	0.452
I79_007315	I79_020576	G3HA72	G3IAF5	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.508
I79_007707	Adipoq	G3HB86	G3HYG0	Retinoic acid receptor responder protein 2.	Adiponectin.	0.432
I79_010817	I79_001272	G3HJH2	G3GUB8	Laminin subunit alpha-4.	Integrin alpha-6; Belongs to the integrin alpha chain family.	0.715
I79_010817	Lamb3	G3HJH2	G3H2M7	Laminin subunit alpha-4.	Laminin subunit beta-3.	0.817