STRINGSTRING
Cav1 Cav1 Gch1 Gch1 Gla Gla Akt1 Akt1 Arg2 Arg2 Cav3 Cav3 I79_003683 I79_003683 Lep Lep Esr1 Esr1 I79_000677 I79_000677 Atp2b4 Atp2b4 Tert Tert I79_025454 I79_025454 I79_024941 I79_024941 Nosip Nosip I79_024744 I79_024744 I79_024415 I79_024415 I79_020786 I79_020786 Stpg4 Stpg4 I79_018847 I79_018847 Agtr2 Agtr2 IL1B IL1B I79_016684 I79_016684 Tnf Tnf Acvr2a Acvr2a I79_015685 I79_015685 Scarb1 Scarb1 Nod1 Nod1 Nus1 Nus1 CgPICR_017756 CgPICR_017756 Apoe Apoe I79_012336 I79_012336 Npr3 Npr3 I79_009116 I79_009116 I79_009115 I79_009115 I79_008941 I79_008941 S100a1 S100a1 Calm2 Calm2 Gsk3b Gsk3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Gch1GTP cyclohydrolase 1. (248 aa)
GlaAlpha-galactosidase. (341 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Arg2Arginase. (305 aa)
Cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
I79_003683Nogo-B receptor. (291 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Esr1Estrogen receptor. (200 aa)
I79_000677Cannabinoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
Atp2b4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1189 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
I79_024941Calmodulin; Belongs to the calmodulin family. (149 aa)
NosipNitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (301 aa)
I79_0247445-hydroxytryptamine receptor 2B. (407 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
I79_020786Calmodulin; Belongs to the calmodulin family. (141 aa)
Stpg4Calmodulin; Belongs to the calmodulin family. (211 aa)
I79_018847Calmodulin; Belongs to the calmodulin family. (152 aa)
Agtr2Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_016684Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
I79_015685EF-hand domain-containing protein. (101 aa)
Scarb1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
Nod1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
Nus1Nogo-B receptor. (193 aa)
CgPICR_017756Calmodulin-like protein; Belongs to the calmodulin family. (98 aa)
ApoeApolipoprotein E. (313 aa)
I79_012336Protein tyrosine kinase 2 beta. (53 aa)
Npr3Atrial natriuretic peptide clearance receptor. (387 aa)
I79_009116Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
I79_009115Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
S100a1Protein S100; Belongs to the S-100 family. (94 aa)
Calm2Calmodulin; Belongs to the calmodulin family. (161 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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