(19 nodes) Regulation of hair follicle development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	I79_024240	Forkhead box protein N1. (293 aa)
	I79_020442	Heparanase. (563 aa)
	Krt17	Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (432 aa)
	Wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	I79_018655	Galanin. (198 aa)
	I79_017912	Nuclear mitotic apparatus protein 1; Belongs to the transient receptor (TC 1.A.4) family. (3026 aa)
	Tradd	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (306 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Inhba	Inhibin beta A chain-like protein. (424 aa)
	Smad4	Mothers against decapentaplegic-like 4. (259 aa)
	Cdh3	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (429 aa)
	Mysm1	Histone H2A deubiquitinase MYSM1. (721 aa)
	Fst	Follistatin. (316 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	I79_000445	Fermitin family-like 1. (641 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fst	Inhba	G3HE00	G3HVA1	Follistatin.	Inhibin beta A chain-like protein.	0.998
Fst	Smad4	G3HE00	G3HTR4	Follistatin.	Mothers against decapentaplegic-like 4.	0.462
I79_000092	Smad4	G3GRE7	G3HTR4	Transforming growth factor beta; Belongs to the TGF-beta family.	Mothers against decapentaplegic-like 4.	0.631
I79_000092	Tnf	G3GRE7	G3HZG9	Transforming growth factor beta; Belongs to the TGF-beta family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.427
I79_000092	Wnt5a	G3GRE7	G3GUT6	Transforming growth factor beta; Belongs to the TGF-beta family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.425
I79_024240	Smad4	G3IK47	G3HTR4	Forkhead box protein N1.	Mothers against decapentaplegic-like 4.	0.437
Inhba	Fst	G3HVA1	G3HE00	Inhibin beta A chain-like protein.	Follistatin.	0.998
Inhba	Smad4	G3HVA1	G3HTR4	Inhibin beta A chain-like protein.	Mothers against decapentaplegic-like 4.	0.676
Msx2	Smad4	G3H1A6	G3HTR4	Homeobox protein MSX-2.	Mothers against decapentaplegic-like 4.	0.438
Ngfr	Tradd	G3HJP7	G3HZK4	Tumor necrosis factor receptor superfamily member 16.	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	0.837
Smad4	Fst	G3HTR4	G3HE00	Mothers against decapentaplegic-like 4.	Follistatin.	0.462
Smad4	I79_000092	G3HTR4	G3GRE7	Mothers against decapentaplegic-like 4.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.631
Smad4	I79_024240	G3HTR4	G3IK47	Mothers against decapentaplegic-like 4.	Forkhead box protein N1.	0.437
Smad4	Inhba	G3HTR4	G3HVA1	Mothers against decapentaplegic-like 4.	Inhibin beta A chain-like protein.	0.676
Smad4	Msx2	G3HTR4	G3H1A6	Mothers against decapentaplegic-like 4.	Homeobox protein MSX-2.	0.438
Smo	Wnt5a	G3GZ55	G3GUT6	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.510
Tnf	I79_000092	G3HZG9	G3GRE7	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.427
Tnf	Tradd	G3HZG9	G3HZK4	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	0.985
Tradd	Ngfr	G3HZK4	G3HJP7	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	Tumor necrosis factor receptor superfamily member 16.	0.837
Tradd	Tnf	G3HZK4	G3HZG9	Tumor necrosis factor receptor type 1-associated DEATH domain protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.985