(19 nodes) Ventricular cardiac muscle cell differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Nkx2-6	Homeobox protein Nkx-2.6. (273 aa)
	Pitx2	Homeobox protein. (322 aa)
	Rxra	Retinoic acid receptor RXR-alpha. (439 aa)
	Hey2	Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
	I79_018785	Retinoic acid receptor alpha. (484 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (147 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	Rxrb	Retinoic acid receptor RXR-beta. (101 aa)
	Bmp10	Bone morphogenetic protein 10. (399 aa)
	Lmna	Lamin-A/C; Belongs to the intermediate filament family. (563 aa)
	Mef2c	Myocyte-specific enhancer factor 2C. (465 aa)
	I79_007135	Homeobox protein Nkx-2.5. (223 aa)
	Fhl2	Four and a half LIM domains protein 2. (279 aa)
	Mef2a	Myocyte-specific enhancer factor 2A. (496 aa)
	Rarb	Retinoic acid receptor beta. (284 aa)
	I79_005213	Nuclear receptor domain-containing protein. (162 aa)
	I79_003100	Myocardin. (371 aa)
	Myh10	Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
	Prox1	Prospero homeobox protein 1. (738 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp10	I79_007135	G3HIB8	G3H9Q5	Bone morphogenetic protein 10.	Homeobox protein Nkx-2.5.	0.410
Cdk1	Lmna	G3HVL1	G3HG95	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Lamin-A/C; Belongs to the intermediate filament family.	0.487
Hey2	Pitx2	G3IB43	G3IHV5	Hairy/enhancer-of-split related with YRPW motif protein 2.	Homeobox protein.	0.467
I79_003100	I79_007135	G3GZ48	G3H9Q5	Myocardin.	Homeobox protein Nkx-2.5.	0.648
I79_003100	Mef2c	G3GZ48	G3HAW1	Myocardin.	Myocyte-specific enhancer factor 2C.	0.564
I79_005213	I79_018785	G3H4K8	G3I5N2	Nuclear receptor domain-containing protein.	Retinoic acid receptor alpha.	0.778
I79_005213	Rarb	G3H4K8	G3H4K9	Nuclear receptor domain-containing protein.	Retinoic acid receptor beta.	0.500
I79_005213	Rxra	G3H4K8	G3IDY0	Nuclear receptor domain-containing protein.	Retinoic acid receptor RXR-alpha.	0.901
I79_005213	Rxrb	G3H4K8	G3HQS1	Nuclear receptor domain-containing protein.	Retinoic acid receptor RXR-beta.	0.775
I79_007135	Bmp10	G3H9Q5	G3HIB8	Homeobox protein Nkx-2.5.	Bone morphogenetic protein 10.	0.410
I79_007135	I79_003100	G3H9Q5	G3GZ48	Homeobox protein Nkx-2.5.	Myocardin.	0.648
I79_007135	Mef2a	G3H9Q5	G3H592	Homeobox protein Nkx-2.5.	Myocyte-specific enhancer factor 2A.	0.870
I79_007135	Mef2c	G3H9Q5	G3HAW1	Homeobox protein Nkx-2.5.	Myocyte-specific enhancer factor 2C.	0.849
I79_018785	I79_005213	G3I5N2	G3H4K8	Retinoic acid receptor alpha.	Nuclear receptor domain-containing protein.	0.778
I79_018785	Rarb	G3I5N2	G3H4K9	Retinoic acid receptor alpha.	Retinoic acid receptor beta.	0.781
I79_018785	Rxra	G3I5N2	G3IDY0	Retinoic acid receptor alpha.	Retinoic acid receptor RXR-alpha.	0.988
I79_018785	Rxrb	G3I5N2	G3HQS1	Retinoic acid receptor alpha.	Retinoic acid receptor RXR-beta.	0.871
Lmna	Cdk1	G3HG95	G3HVL1	Lamin-A/C; Belongs to the intermediate filament family.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.487
Mef2a	I79_007135	G3H592	G3H9Q5	Myocyte-specific enhancer factor 2A.	Homeobox protein Nkx-2.5.	0.870
Mef2a	Mef2c	G3H592	G3HAW1	Myocyte-specific enhancer factor 2A.	Myocyte-specific enhancer factor 2C.	0.957