STRINGSTRING
Hdac2 Hdac2 Polb Polb I79_009034 I79_009034 Txnrd2 Txnrd2 Cav1 Cav1 I79_005745 I79_005745 Mmp2 Mmp2 Cat Cat Sod2 Sod2 I79_014954 I79_014954 PPARG PPARG Pdgfrb Pdgfrb I79_013660 I79_013660 Fas Fas H671_3g9857 H671_3g9857 CgPICR_014700 CgPICR_014700 Foxo1 Foxo1 Epo Epo Polg Polg Alox5 Alox5 Bnip3 Bnip3 Pdpn Pdpn cytb cytb ATP6 ATP6 Kcna5 Kcna5 Slc7a5 Slc7a5 I79_012903 I79_012903 Col1a1 Col1a1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
PolbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
I79_009034Thioredoxin reductase 2, mitochondrial. (116 aa)
Txnrd2Thioredoxin reductase 2, mitochondrial. (276 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
I79_005745NADPH oxidase 1. (395 aa)
Mmp272 kDa type IV collagenase. (662 aa)
CatCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (555 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
I79_014954Autophagy-related protein 7. (439 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
PdgfrbBeta-type platelet-derived growth factor receptor. (528 aa)
I79_013660Beta-type platelet-derived growth factor receptor. (454 aa)
FasTumor necrosis factor receptor superfamily member 6. (124 aa)
H671_3g9857Tumor necrosis factor receptor superfamily member 6-like protein. (170 aa)
CgPICR_014700C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
Foxo1Forkhead box protein O1. (469 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
PolgDNA polymerase subunit gamma-1. (1215 aa)
Alox5Arachidonate 5-lipoxygenase. (674 aa)
Bnip3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
PdpnPodoplanin. (55 aa)
cytbCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
ATP6ATP synthase subunit a. (226 aa)
Kcna5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
Slc7a5Large neutral amino acids transporter small subunit 1. (506 aa)
I79_012903Pulmonary surfactant-associated protein A. (238 aa)
Col1a1Collagen alpha-1(I) chain. (355 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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