(91 nodes) Canonical Wnt signaling pathway network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_014483	Serine/threonine-protein kinase 3. (118 aa)
	Rspo3	R-spondin-3. (81 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	Bcl9l	B-cell CLL/lymphoma 9-like protein. (1497 aa)
	Tcf7l2	Transcription factor 7-like 1. (73 aa)
	Wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
	I79_022484	Rap guanine nucleotide exchange factor 1. (934 aa)
	Fzd4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
	I79_021911	Casein kinase I isoform epsilon. (370 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	Wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Reck	Reversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
	I79_020843	Reversion-inducing cysteine-rich protein with Kazal motifs. (107 aa)
	I79_020783	Transcription factor 7-like 2. (451 aa)
	Klf4	Krueppel-like factor 4. (474 aa)
	Wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	Lgr4	Leucine-rich repeat-containing G-protein coupled receptor 4. (231 aa)
	Lrp5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
	I79_018586	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
	Dvl1	Putative segment polarity protein dishevelledVL-1-like protein. (695 aa)
	I79_018043	Frizzled-6. (109 aa)
	I79_018023	Ectodysplasin-A; Belongs to the tumor necrosis factor family. (192 aa)
	I79_017833	Lymphoid enhancer-binding factor 1. (276 aa)
	Dvl3	Segment polarity protein dishevelled-like DVL-3. (503 aa)
	Fzd10	Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (488 aa)
	Foxo1	Forkhead box protein O1. (469 aa)
	Wnt8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (322 aa)
	Siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	Sostdc1	Sclerostin domain-containing protein 1. (193 aa)
	I79_015321	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (243 aa)
	I79_015320	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
	I79_014993	SCY1-like protein 2. (631 aa)
	I79_014991	SCY1-like protein 2. (92 aa)
	Wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Fzd5	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (616 aa)
	Tcf7l1	Transcription factor 7-like 1. (297 aa)
	Jup	Junction plakoglobin. (1148 aa)
	Fzd2	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (522 aa)
	Sost	Sclerostin. (213 aa)
	Fzd1	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (514 aa)
	Cdh3	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	Stk3	Serine/threonine-protein kinase 3. (260 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
	I79_010290	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	I79_010137	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (262 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	I79_009708	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (332 aa)
	Siah2	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (195 aa)
	Apc	Adenomatous polyposis coli protein. (2488 aa)
	Wnt8a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (195 aa)
	Rspo1	R-spondin-1. (262 aa)
	Sdc1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (285 aa)
	Pygo2	Pygopus-like 2. (405 aa)
	Axin1	Axin-1. (863 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	Gsk3b	Glycogen synthase kinase-3 beta. (328 aa)
	Ext1	Exostosin-1. (388 aa)
	Fzd9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (439 aa)
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Rab5a	Ras-related protein Rab-5A. (215 aa)
	Lats2	Serine/threonine-protein kinase LATS2. (1040 aa)
	I79_006675	Secreted frizzled-related protein 3. (286 aa)
	Wnt5b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	Dkk1	Dickkopf-related protein 1. (269 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_005573	Secreted frizzled-related protein 2. (268 aa)
	Bcl9	B-cell CLL/lymphoma 9 protein. (1399 aa)
	Dixdc1	Dixin. (689 aa)
	Tcf7	Transcription factor 7. (213 aa)
	Isl1	Insulin gene enhancer protein ISL-1. (257 aa)
	Fzd3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	Edn1	Endothelin-1. (202 aa)
	Sfrp5	Secreted frizzled-related protein 5. (247 aa)
	Fzd7	Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (438 aa)
	Phf23	Segment polarity protein dishevelled-like DVL-2. (697 aa)
	Foxo3	Forkhead box protein O3. (672 aa)
	I79_002288	Disrupted in schizophrenia 1-like. (648 aa)
	Sfrp4	Secreted frizzled-related protein 4. (348 aa)
	I79_001484	65 kDa Yes-associated protein. (257 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Wnt7a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
	Pygo1	Pygopus-like 1. (385 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	Plpp3	Lipid phosphate phosphohydrolase 3. (312 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Apc	Axin1	G3HF07	G3HBS5	Adenomatous polyposis coli protein.	Axin-1.	0.998
Apc	Ctnnb1	G3HF07	G3H996	Adenomatous polyposis coli protein.	Catenin beta-1.	0.999
Apc	Dvl1	G3HF07	G3I423	Adenomatous polyposis coli protein.	Putative segment polarity protein dishevelledVL-1-like protein.	0.963
Apc	Dvl3	G3HF07	G3I320	Adenomatous polyposis coli protein.	Segment polarity protein dishevelled-like DVL-3.	0.949
Apc	Gsk3b	G3HF07	G3HAI0	Adenomatous polyposis coli protein.	Glycogen synthase kinase-3 beta.	0.995
Apc	I79_007641	G3HF07	G3HB26	Adenomatous polyposis coli protein.	Low-density lipoprotein receptor-related protein 6.	0.440
Apc	I79_010136	G3HF07	G3HHN2	Adenomatous polyposis coli protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.443
Apc	I79_017833	G3HF07	G3I333	Adenomatous polyposis coli protein.	Lymphoid enhancer-binding factor 1.	0.533
Apc	I79_020783	G3HF07	G3IAZ7	Adenomatous polyposis coli protein.	Transcription factor 7-like 2.	0.508
Apc	I79_021911	G3HF07	G3IDX3	Adenomatous polyposis coli protein.	Casein kinase I isoform epsilon.	0.552
Apc	Jup	G3HF07	G3HLU9	Adenomatous polyposis coli protein.	Junction plakoglobin.	0.890
Apc	Lrp5	G3HF07	G3I5B4	Adenomatous polyposis coli protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.488
Apc	Lrp6	G3HF07	G3HB27	Adenomatous polyposis coli protein.	Low-density lipoprotein receptor-related protein 6.	0.440
Apc	Phf23	G3HF07	G3GYA1	Adenomatous polyposis coli protein.	Segment polarity protein dishevelled-like DVL-2.	0.530
Apc	Tcf7	G3HF07	G3H2C7	Adenomatous polyposis coli protein.	Transcription factor 7.	0.951
Apc	Tcf7l1	G3HF07	G3HPZ8	Adenomatous polyposis coli protein.	Transcription factor 7-like 1.	0.950
Apc	Tcf7l2	G3HF07	G3IIN4	Adenomatous polyposis coli protein.	Transcription factor 7-like 1.	0.948
Apc	Wnt1	G3HF07	G3I6J2	Adenomatous polyposis coli protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.496
Apc	Wnt8a	G3HF07	G3HF01	Adenomatous polyposis coli protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.461
Apc	Wnt8b	G3HF07	G3HZ94	Adenomatous polyposis coli protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.461