(24 nodes) Positive regulation of glial cell proliferation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_017561	Tyrosine-protein kinase Lyn. (101 aa)
	Hvcn1	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (511 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	I79_002693	Netrin-1. (252 aa)
	E2f1	Transcription factor E2F1. (367 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	Vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
	Prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (560 aa)
	Gfap	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (427 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	CgPICR_008504	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like protein. (326 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Slc7a5	Large neutral amino acids transporter small subunit 1. (506 aa)
	Atxn1	Ataxin-1. (790 aa)
	Ptk2	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
	I79_002099	Vascular endothelial growth factor receptor 1. (115 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Lta	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (202 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Prkch	Protein kinase C eta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (635 aa)
	Tspo	Translocator protein. (169 aa)
	I79_015109	Interleukin-6. (174 aa)
	I79_014451	Pro-neuregulin-1, membrane-bound isoform. (639 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E2f1	Myc	G3HAM7	G3IP28	Transcription factor E2F1.	Myc proto-oncogene protein.	0.721
Gfap	I79_015109	G3HLL7	G3HVW6	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Interleukin-6.	0.654
Gfap	IL1B	G3HLL7	G3I1B0	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.567
Gfap	Igf1	G3HLL7	G3H672	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Insulin-like growth factor I.	0.497
Gfap	Tnf	G3HLL7	G3HZG9	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.413
I79_002099	I79_017561	G3GWH4	G3I2D2	Vascular endothelial growth factor receptor 1.	Tyrosine-protein kinase Lyn.	0.407
I79_002099	Lyn	G3GWH4	G3I2D1	Vascular endothelial growth factor receptor 1.	Tyrosine-protein kinase.	0.407
I79_002099	Ptk2	G3GWH4	G3I7E2	Vascular endothelial growth factor receptor 1.	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.448
I79_002099	Vegfc	G3GWH4	G3HGL6	Vascular endothelial growth factor receptor 1.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.911
I79_002693	Ptk2	G3GY38	G3I7E2	Netrin-1.	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.487
I79_008941	I79_014451	G3HEF7	G3HU47	Receptor protein-tyrosine kinase.	Pro-neuregulin-1, membrane-bound isoform.	0.858
I79_008941	I79_015109	G3HEF7	G3HVW6	Receptor protein-tyrosine kinase.	Interleukin-6.	0.574
I79_008941	I79_017561	G3HEF7	G3I2D2	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase Lyn.	0.606
I79_008941	IL1B	G3HEF7	G3I1B0	Receptor protein-tyrosine kinase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.557
I79_008941	Igf1	G3HEF7	G3H672	Receptor protein-tyrosine kinase.	Insulin-like growth factor I.	0.572
I79_008941	Lyn	G3HEF7	G3I2D1	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.606
I79_008941	Mtor	G3HEF7	G3IEE8	Receptor protein-tyrosine kinase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.416
I79_008941	Myc	G3HEF7	G3IP28	Receptor protein-tyrosine kinase.	Myc proto-oncogene protein.	0.437
I79_008941	Ptk2	G3HEF7	G3I7E2	Receptor protein-tyrosine kinase.	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.965
I79_008941	Tnf	G3HEF7	G3HZG9	Receptor protein-tyrosine kinase.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.565