(49 nodes) Positive regulation of transcription initiation from RNA polymerase II promoter network (Cricetulus griseus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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textmining

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protein homology

Your Input:
	I79_015699	Activated RNA polymerase II transcriptional coactivator p15. (124 aa)
	I79_014474	Cyclic AMP-responsive element-binding protein 1. (325 aa)
	Ahr	Aryl hydrocarbon receptor. (247 aa)
	MED17	Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (649 aa)
	Taf11	Transcription initiation factor TFIID subunit 11. (106 aa)
	Dhx36	Putative ATP-dependent RNA helicase DHX36. (922 aa)
	Taf7	Transcription initiation factor TFIID subunit 7. (341 aa)
	Srf	Serum response factor. (361 aa)
	MED4-2	Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa)
	Taf6	Transcription initiation factor TFIID subunit 6. (678 aa)
	Hnf1b	Hepatocyte nuclear factor 1-beta. (593 aa)
	I79_019105	26S protease regulatory subunit S10B. (284 aa)
	Wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	I79_019144	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1336 aa)
	I79_019493	Mediator of RNA polymerase II transcription subunit 12. (251 aa)
	Med12	Mediator of RNA polymerase II transcription subunit 12. (1703 aa)
	I79_020821	Transcription initiation factor TFIID subunit 5. (416 aa)
	Taf13	Transcription initiation factor TFIID subunit 13-like protein. (124 aa)
	Taf10	Transcription initiation factor TFIID subunit 10. (125 aa)
	I79_022457	Transcription initiation factor TFIID subunit 2. (89 aa)
	I79_022459	Transcription initiation factor TFIID subunit 2. (62 aa)
	I79_022460	Transcription initiation factor TFIID subunit 2. (125 aa)
	I79_023698	Activated RNA polymerase II transcriptional coactivator p15. (59 aa)
	Med24	Mediator of RNA polymerase II transcription subunit 24. (324 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Paxip1	PAX-interacting protein 1. (91 aa)
	I79_025879	Mediator of RNA polymerase II transcription subunit 24. (203 aa)
	Taf8	Transcription initiation factor TFIID subunit 8. (308 aa)
	Pou5f1	POU domain protein. (358 aa)
	H671_21027	DNA excision repair protein ERCC-1. (111 aa)
	Sub1	Activated RNA polymerase II transcriptional coactivator p15. (59 aa)
	I79_010330	Hepatocyte nuclear factor 1-alpha. (668 aa)
	Ikzf1	DNA-binding protein Ikaros. (489 aa)
	MED8	Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (268 aa)
	MED16	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (828 aa)
	Taf4b	Transcription initiation factor TFIID subunit 4B. (571 aa)
	I79_007326	POU domain, class 5, transcription factor 1. (221 aa)
	I79_007135	Homeobox protein Nkx-2.5. (223 aa)
	I79_006285	DNA repair protein complementing XP-A cells-like. (231 aa)
	I79_006232	PAX-interacting protein 1. (79 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	MED18	Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
	Taf12	Transcription initiation factor TFIID subunit 12. (161 aa)
	Med30	Mediator of RNA polymerase II transcription subunit 30. (73 aa)
	Cand1	Cullin-associated NEDD8-dissociated protein 1. (1206 aa)
	Taf4	Transcription initiation factor TFIID subunit 4. (630 aa)
	Med14	Mediator of RNA polymerase II transcription subunit 14. (334 aa)
	Gtf2a2	Transcription initiation factor IIA subunit 2. (63 aa)
	Taf3	Transcription initiation factor TFIID subunit 3. (930 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gtf2a2	I79_020821	G3GRN0	G3IB33	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 5.	0.904
Gtf2a2	I79_022457	G3GRN0	G3IFD5	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 2.	0.750
Gtf2a2	I79_022459	G3GRN0	G3IFD7	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 2.	0.750
Gtf2a2	I79_022460	G3GRN0	G3IFD8	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 2.	0.750
Gtf2a2	I79_025879	G3GRN0	G3IPG8	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 24.	0.528
Gtf2a2	MED16	G3GRN0	G3HF51	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.679
Gtf2a2	MED17	G3GRN0	G3HSP6	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.871
Gtf2a2	MED18	G3GRN0	G3H1Z1	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.676
Gtf2a2	MED4-2	G3GRN0	G3HZ48	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.677
Gtf2a2	MED8	G3GRN0	G3HFH0	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.676
Gtf2a2	Med1	G3GRN0	G3H5X2	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.525
Gtf2a2	Med14	G3GRN0	G3GSG9	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 14.	0.860
Gtf2a2	Med24	G3GRN0	G3INY5	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 24.	0.528
Gtf2a2	Med30	G3GRN0	G3H0A1	Transcription initiation factor IIA subunit 2.	Mediator of RNA polymerase II transcription subunit 30.	0.698
Gtf2a2	Taf10	G3GRN0	G3IDE5	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 10.	0.899
Gtf2a2	Taf11	G3GRN0	G3HS01	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 11.	0.980
Gtf2a2	Taf12	G3GRN0	G3H1Y6	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 12.	0.942
Gtf2a2	Taf13	G3GRN0	G3IC75	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 13-like protein.	0.939
Gtf2a2	Taf3	G3GRN0	G3GR60	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 3.	0.854
Gtf2a2	Taf4	G3GRN0	G3GWS2	Transcription initiation factor IIA subunit 2.	Transcription initiation factor TFIID subunit 4.	0.934