STRINGSTRING
PPARG PPARG Sh2b1 Sh2b1 I79_019517 I79_019517 Tgfb1 Tgfb1 Jak2 Jak2 I79_006254 I79_006254 Nodal Nodal Rbpms Rbpms Bmpr2 Bmpr2 Tgfbr1 Tgfbr1 Bmp6 Bmp6 Tdp2 Tdp2 Tgfb3 Tgfb3 I79_009834 I79_009834 Nup93 Nup93 Smad4 Smad4 Parp1 Parp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Sh2b1SH2B adapter protein 1. (443 aa)
I79_019517SH2B adapter protein 1. (226 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
NodalNodal. (309 aa)
RbpmsRNA-binding protein with multiple splicing. (116 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
Tdp2Uncharacterized protein KIAA0319. (1024 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
I79_009834Disabled-like 2. (705 aa)
Nup93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (780 aa)
Smad4Mothers against decapentaplegic-like 4. (259 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (971 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.