STRINGSTRING
Pim1 Pim1 Kcnk2 Kcnk2 Prox1 Prox1 Foxp1 Foxp1 Tbx5 Tbx5 Jarid2 Jarid2 Ccnd2 Ccnd2 I79_001484 I79_001484 Tgfbr2 Tgfbr2 Fgf20 Fgf20 Edn1 Edn1 Cav3 Cav3 Meis1 Meis1 Nog Nog I79_004031 I79_004031 I79_004399 I79_004399 Rgs2 Rgs2 I79_005331 I79_005331 Igf1 Igf1 I79_005909 I79_005909 Cxadr Cxadr Tgfbr1 Tgfbr1 I79_006679 I79_006679 Rbp4 Rbp4 Tbx2 Tbx2 Wnt2 Wnt2 I79_007089 I79_007089 I79_007090 I79_007090 I79_007135 I79_007135 Sirt1 Sirt1 Mef2c Mef2c I79_007989 I79_007989 Trip10 Trip10 Ctdp1 Ctdp1 Tgfbr3 Tgfbr3 I79_009001 I79_009001 Apc Apc I79_009500 I79_009500 Hdac2 Hdac2 I79_010352 I79_010352 Bmp10 Bmp10 I79_011152 I79_011152 Dusp6 Dusp6 Tomm70 Tomm70 Dusp9 Dusp9 Vgll4 Vgll4 Cdk1 Cdk1 Gli1 Gli1 Ddx39b Ddx39b Mapk14 Mapk14 Gsk3a Gsk3a I79_017320 I79_017320 I79_017749 I79_017749 I79_018586 I79_018586 Tbx20 Tbx20 Slc25a4 Slc25a4 Akap6 Akap6 Hey2 Hey2 G6pd G6pd Rbpj Rbpj Sav1 Sav1 Mtor Mtor I79_022390 I79_022390 Ppara Ppara I79_023178 I79_023178 I79_023241 I79_023241 Fgfr2 Fgfr2 I79_024406 I79_024406 Pak1 Pak1 I79_025549 I79_025549 I79_025570 I79_025570 I79_025672 I79_025672 I79_025858 I79_025858 I79_025994 I79_025994 I79_026256 I79_026256 Gja1 Gja1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pim1Proto-oncogene serine/threonine-protein kinase Pim-1. (250 aa)
Kcnk2Potassium channel subfamily K member 2. (215 aa)
Prox1Prospero homeobox protein 1. (738 aa)
Foxp1Forkhead box protein P1. (696 aa)
Tbx5T-box transcription factor TBX5. (518 aa)
Jarid2Protein Jumonji. (1221 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
Edn1Endothelin-1. (202 aa)
Cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
Meis1Homeobox protein Meis1. (390 aa)
NogNoggin. (117 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
I79_004399Neural cell adhesion molecule 1. (1071 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005909Peptidyl-prolyl cis-trans isomerase. (242 aa)
CxadrCoxsackievirus and adenovirus receptor-like. (394 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Rbp4Retinol-binding protein 4; Belongs to the calycin superfamily. Lipocalin family. (338 aa)
Tbx2T-box transcription factor TBX2. (234 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007135Homeobox protein Nkx-2.5. (223 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
I79_007989Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (375 aa)
Trip10Cdc42-interacting protein 4. (610 aa)
Ctdp1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (848 aa)
Tgfbr3TGF-beta receptor type III. (849 aa)
I79_009001Zinc finger protein ZFPM2. (718 aa)
ApcAdenomatous polyposis coli protein. (2488 aa)
I79_009500Mitogen-activated protein kinase 1. (68 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
I79_010352Acetyl-CoA carboxylase 2. (2287 aa)
Bmp10Bone morphogenetic protein 10. (399 aa)
I79_011152Peptidase inhibitor 16; Belongs to the CRISP family. (396 aa)
Dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
Tomm70Mitochondrial import receptor subunit TOM70. (384 aa)
Dusp9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (335 aa)
Vgll4Transcription cofactor vestigial-like protein 4. (282 aa)
Cdk1Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
Gli1Zinc finger protein GLI1. (1104 aa)
Ddx39bSpliceosome RNA helicase BAT1. (288 aa)
Mapk14Mitogen-activated protein kinase. (349 aa)
Gsk3aGlycogen synthase kinase-3 alpha. (653 aa)
I79_017320Poly [ADP-ribose] polymerase. (513 aa)
I79_017749Mitogen-activated protein kinase 11. (413 aa)
I79_018586Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
Tbx20T-box transcription factor TBX20. (445 aa)
Slc25a4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (272 aa)
Akap6A-kinase anchor protein 6. (1368 aa)
Hey2Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
G6pdGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (624 aa)
RbpjRecombining binding protein suppressor of hairless-like protein. (486 aa)
Sav1Protein salvador-like 1. (210 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
I79_023178Zinc finger protein 551. (887 aa)
I79_023241Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (558 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_024406A-kinase anchor protein 6. (211 aa)
Pak1Serine/threonine-protein kinase PAK 1. (325 aa)
I79_025549WNT1-inducible-signaling pathway protein 1. (274 aa)
I79_025570Spliceosome RNA helicase Bat1. (229 aa)
I79_025672Spliceosome RNA helicase BAT1. (155 aa)
I79_025858Spliceosome RNA helicase BAT1. (66 aa)
I79_025994WNT1-inducible-signaling pathway protein 1. (136 aa)
I79_026256Spliceosome RNA helicase Bat1. (103 aa)
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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