(34 nodes) Branching involved in mammary gland duct morphogenesis network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Lrp5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
	I79_019286	Androgen receptor. (295 aa)
	Epha2	Ephrin type-A receptor 2. (942 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	Areg	Amphiregulin. (230 aa)
	Vdr	Vitamin D3 receptor. (372 aa)
	Ar	Androgen receptor. (517 aa)
	Csf1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
	I79_026146	ETS translocation variant 4. (95 aa)
	I79_025795	Vitamin D3 receptor. (86 aa)
	I79_001073	C-C motif chemokine. (72 aa)
	Tbx3	T-box transcription factor TBX3. (709 aa)
	Phb2	Prohibitin-2. (396 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	I79_001487	Progesterone receptor. (741 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Csmd1	CUB and sushi domain-containing protein 1. (106 aa)
	I79_003312	CUB and sushi domain-containing protein 1. (3110 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	Kdm5b	Lysine-specific demethylase 5B. (748 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	I79_006792	DUF1518 domain-containing protein. (200 aa)
	Ncoa3	Nuclear receptor coactivator 3. (1211 aa)
	I79_006881	CUB and sushi domain-containing protein 2. (3527 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	I79_026151	ETS translocation variant 4. (69 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	Tfap2c	Transcription factor AP-2 gamma. (463 aa)
	Pml	Putative transcription factor PML. (540 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
	I79_010613	Transcription factor AP-2 gamma. (236 aa)
	Ddr1	Epithelial discoidin domain-containing receptor 1 isoform 1. (910 aa)
	I79_017861	Solute carrier family 12 member 2. (706 aa)
	Btrc	F-box/WD repeat-containing protein 1A. (488 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ar	I79_001487	G3IGU9	G3GUW3	Androgen receptor.	Progesterone receptor.	0.742
Ar	I79_006792	G3IGU9	G3H8T1	Androgen receptor.	DUF1518 domain-containing protein.	0.790
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ar	Med1	G3IGU9	G3H5X2	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.485
Ar	Ncoa3	G3IGU9	G3H8T2	Androgen receptor.	Nuclear receptor coactivator 3.	0.790
Ar	Src	G3IGU9	G3GXX7	Androgen receptor.	Tyrosine-protein kinase.	0.571
Areg	Epha2	G3IBU4	G3I863	Amphiregulin.	Ephrin type-A receptor 2.	0.683
Areg	I79_001487	G3IBU4	G3GUW3	Amphiregulin.	Progesterone receptor.	0.557
Areg	Src	G3IBU4	G3GXX7	Amphiregulin.	Tyrosine-protein kinase.	0.582
Csf1	Epha2	G3IHR6	G3I863	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Ephrin type-A receptor 2.	0.690
Csf1	I79_001073	G3IHR6	G3GTT4	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	C-C motif chemokine.	0.513
Csf1	Src	G3IHR6	G3GXX7	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tyrosine-protein kinase.	0.590
Csf1	Tgfb1	G3IHR6	G3IA12	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Transforming growth factor beta-1.	0.469
Epha2	Areg	G3I863	G3IBU4	Ephrin type-A receptor 2.	Amphiregulin.	0.683
Epha2	Csf1	G3I863	G3IHR6	Ephrin type-A receptor 2.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.690
Epha2	Src	G3I863	G3GXX7	Ephrin type-A receptor 2.	Tyrosine-protein kinase.	0.424
I79_001073	Csf1	G3GTT4	G3IHR6	C-C motif chemokine.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.513
I79_001487	Ar	G3GUW3	G3IGU9	Progesterone receptor.	Androgen receptor.	0.742
I79_001487	Areg	G3GUW3	G3IBU4	Progesterone receptor.	Amphiregulin.	0.557
I79_001487	I79_006792	G3GUW3	G3H8T1	Progesterone receptor.	DUF1518 domain-containing protein.	0.562