STRINGSTRING
Hoxd13 Hoxd13 Med1 Med1 I79_006225 I79_006225 I79_006254 I79_006254 Tfap2c Tfap2c Fgf1 Fgf1 Tmtc3 Tmtc3 I79_010613 I79_010613 Tnc Tnc Spry1 Spry1 Rdh10 Rdh10 Tgfb1 Tgfb1 Areg Areg Fgfr2 Fgfr2 I79_000973 I79_000973 Wnt5a Wnt5a I79_001484 I79_001484
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hoxd13Homeobox protein Hox-D13. (204 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Tfap2cTranscription factor AP-2 gamma. (463 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Tmtc3Transmembrane and TPR repeat-containing protein 3. (916 aa)
I79_010613Transcription factor AP-2 gamma. (236 aa)
TncTenascin. (2202 aa)
Spry1Protein sprouty-like 1. (313 aa)
Rdh10Retinol dehydrogenase 10. (65 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
AregAmphiregulin. (230 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_000973Transcription factor SOX-10. (360 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.