(65 nodes) Regulation of morphogenesis of a branching structure network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_021155	Paired box protein Pax-2. (503 aa)
	Ntn4	Netrin-4. (574 aa)
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	I79_007063	Hepatocyte growth factor receptor. (1222 aa)
	Bmp7	Bone morphogenetic protein 7. (430 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	Pgf	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	I79_010923	Reticulon. (68 aa)
	Rtn4	Reticulon-4. (806 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	Map3k13	Mitogen-activated protein kinase kinase kinase 13. (431 aa)
	Cdh1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
	Hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	Maged1	Melanoma-associated antigen D1-like protein. (776 aa)
	Snai2	Zinc finger protein SNAI2-like protein. (268 aa)
	I79_013817	NAD-dependent deacetylase sirtuin-6. (334 aa)
	Mecp2	Methyl-CpG-binding protein 2. (203 aa)
	Btbd7	BTB/POZ domain-containing protein 7. (399 aa)
	I79_014492	BTB/POZ domain-containing protein 7. (258 aa)
	Fkbpl	FK506-binding protein-like. (106 aa)
	Lhx1	LIM/homeobox protein Lhx1. (84 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Hoxb7	Homeobox protein Hox-B7. (153 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	Bcl11a	B-cell lymphoma/leukemia 11A. (749 aa)
	Hoxd13	Homeobox protein Hox-D13. (204 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)
	Nog	Noggin. (117 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Mdk	Midkine. (160 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	I79_002251	Type-1 angiotensin II receptor. (117 aa)
	Six2	Homeobox protein SIX2. (299 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Phb2	Prohibitin-2. (396 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	I79_016814	Short stature homeobox protein 2. (194 aa)
	Agtr1	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	I79_017780	Extracellular sulfatase Sulf-1. (787 aa)
	Agtr2	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	Tacstd2	Tumor-associated calcium signal transducer 2-like protein. (318 aa)
	Rxra	Retinoic acid receptor RXR-alpha. (439 aa)
	Lgr4	Leucine-rich repeat-containing G-protein coupled receptor 4. (231 aa)
	I79_021837	Leucine-rich repeat serine/threonine-protein kinase 2. (441 aa)
	I79_021836	Leucine-rich repeat serine/threonine-protein kinase 2. (1184 aa)
	I79_021835	Leucine-rich repeat serine/threonine-protein kinase 2. (354 aa)
	Grem1	Gremlin-1. (117 aa)
	Fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	I79_019286	Androgen receptor. (295 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	Wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
	Ar	Androgen receptor. (517 aa)
	Pax8	Paired box protein Pax-8. (452 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	I79_022007	Homeobox protein SIX4. (673 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Agt	Agtr1	G3GX14	G3I0U1	Angiotensinogen; Belongs to the serpin family.	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	0.996
Agt	Agtr2	G3GX14	G3I4R1	Angiotensinogen; Belongs to the serpin family.	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	0.999
Agt	I79_002251	G3GX14	G3GWW6	Angiotensinogen; Belongs to the serpin family.	Type-1 angiotensin II receptor.	0.968
Agt	Tgfb1	G3GX14	G3IA12	Angiotensinogen; Belongs to the serpin family.	Transforming growth factor beta-1.	0.647
Agt	Tnf	G3GX14	G3HZG9	Angiotensinogen; Belongs to the serpin family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.528
Agtr1	Agt	G3I0U1	G3GX14	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Angiotensinogen; Belongs to the serpin family.	0.996
Agtr1	Agtr2	G3I0U1	G3I4R1	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	0.962
Agtr2	Agt	G3I4R1	G3GX14	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Angiotensinogen; Belongs to the serpin family.	0.999
Agtr2	Agtr1	G3I4R1	G3I0U1	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	0.962
Agtr2	Hoxb7	G3I4R1	G3H5S3	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Homeobox protein Hox-B7.	0.464
Agtr2	I79_002251	G3I4R1	G3GWW6	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Type-1 angiotensin II receptor.	0.636
Ar	Ctnnb1	G3IGU9	G3H996	Androgen receptor.	Catenin beta-1.	0.774
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Bmp7	Ctnnb1	G3HBL1	G3H996	Bone morphogenetic protein 7.	Catenin beta-1.	0.401
Bmp7	Fgf7	G3HBL1	G3IAS3	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.475
Bmp7	Grem1	G3HBL1	G3ID48	Bone morphogenetic protein 7.	Gremlin-1.	0.936
Bmp7	I79_006225	G3HBL1	G3H796	Bone morphogenetic protein 7.	Sonic hedgehog protein.	0.444
Bmp7	I79_006254	G3HBL1	G3H7C4	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.808
Bmp7	Nog	G3HBL1	G3H1C7	Bone morphogenetic protein 7.	Noggin.	0.996
Bmp7	Tgfb1	G3HBL1	G3IA12	Bone morphogenetic protein 7.	Transforming growth factor beta-1.	0.413