STRINGSTRING
Cd74 Cd74 Tlr3 Tlr3 Tlr4 Tlr4 Nod1 Nod1 PANX PANX Myd88 Myd88 Ripk2 Ripk2 I79_011940 I79_011940 Spon2 Spon2 Rtn4 Rtn4 I79_010923 I79_010923 Sema7a Sema7a Ticam1 Ticam1 Sirt1 Sirt1 Nod2 Nod2 Laptm5 Laptm5 Wnt5a Wnt5a Plcg2 Plcg2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cd74H-2 class II histocompatibility antigen gamma chain. (329 aa)
Tlr3Toll-like receptor 3. (164 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Nod1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
PANXPannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
I79_011940Platelet glycoprotein 4; Belongs to the CD36 family. (348 aa)
Spon2Spondin-2. (312 aa)
Rtn4Reticulon-4. (806 aa)
I79_010923Reticulon. (68 aa)
Sema7aSemaphorin-7A; Belongs to the semaphorin family. (560 aa)
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (699 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
Laptm5Lysosomal-associated transmembrane protein 5. (232 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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