(86 nodes) Regulation of protein tyrosine kinase activity network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Adra1a	Alpha-1A adrenergic receptor. (465 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	App	Amyloid beta A4 protein. (433 aa)
	Vps25	Vacuolar protein-sorting-associated protein 25. (176 aa)
	Ncf1	Neutrophil cytosol factor 1. (303 aa)
	Rap2b	Ras-related protein Rap-2b. (183 aa)
	Rack1	Guanine nucleotide-binding protein subunit beta-2-like 1. (276 aa)
	Ngf	Beta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	Zgpat	Zinc finger CCCH-type with G patch domain-containing protein. (188 aa)
	Ptk6	Tyrosine-protein kinase. (450 aa)
	Itgb3	Integrin beta; Belongs to the integrin beta chain family. (975 aa)
	Ptpn1	Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	Dgkq	Diacylglycerol kinase. (491 aa)
	Fbxw9	F-box/WD repeat-containing protein 9. (458 aa)
	Efna1	Ephrin-A1; Belongs to the ephrin family. (205 aa)
	Gprc5a	Retinoic acid-induced protein 3. (354 aa)
	Il34	Interleukin-34. (201 aa)
	I79_007090	Receptor tyrosine-protein kinase erbB-4. (182 aa)
	I79_007089	Receptor tyrosine-protein kinase erbB-4. (225 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Ggnbp2	Gametogenetin-binding protein 2. (667 aa)
	Hyal2	Hyaluronidase. (359 aa)
	Socs4	Suppressor of cytokine signaling 4. (435 aa)
	I79_006143	Inhibitor of Bruton tyrosine kinase. (1086 aa)
	Angpt4	Angiopoietin-4. (499 aa)
	I79_005696	p130Cas-associated protein. (1144 aa)
	I79_005331	Receptor tyrosine-protein kinase erbB-4. (480 aa)
	Prnp	Major prion protein; Belongs to the prion family. (254 aa)
	Adora1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	Tal1	T-cell acute lymphocytic leukemia protein 1-like. (329 aa)
	Dlg4	Disks large-like 4. (216 aa)
	Phf23	Segment polarity protein dishevelled-like DVL-2. (697 aa)
	Chmp6	Charged multivesicular body protein 6. (176 aa)
	Ghrl	Appetite-regulating hormone. (100 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Dusp22	Dual specificity protein phosphatase 22. (197 aa)
	I79_002032	Protein Dok-7. (453 aa)
	I79_001115	Amyloid-like protein 2. (682 aa)
	I79_001015	Low-density lipoprotein receptor-related protein 8. (764 aa)
	Pak2	Non-specific serine/threonine protein kinase. (524 aa)
	Mvp	Major vault protein. (861 aa)
	I79_018310	FGFR1 oncogene partner. (281 aa)
	I79_018306	Ephrin type-A receptor 4. (932 aa)
	Agrn	Agrin. (2036 aa)
	Pdgfb	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
	Dlg3	Disks large-like 3; Belongs to the MAGUK family. (868 aa)
	Zfyve28	Lateral signaling target protein 2-like. (908 aa)
	I79_016131	Charged multivesicular body protein 6. (186 aa)
	H671_4g12667	Alpha-2-HS-glycoprotein. (333 aa)
	I79_014973	Pro-neuregulin-2, membrane-bound isoform. (386 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	I79_014451	Pro-neuregulin-1, membrane-bound isoform. (639 aa)
	Nrg1	Pro-neuregulin-1, membrane-bound isoform. (259 aa)
	Ncapg2	Condensin-2 complex subunit G2. (533 aa)
	I79_014319	Condensin-2 complex subunit G2. (207 aa)
	I79_014053	Abl interactor 1. (280 aa)
	Nedd9	Enhancer of filamentation 1. (830 aa)
	I79_013659	Macrophage colony-stimulating factor 1 receptor. (595 aa)
	Afap1l2	Actin filament-associated protein 1-like 2. (826 aa)
	Unc119	Protein unc-119-like A. (80 aa)
	Thy1	Thy-1 membrane glycoprotein. (147 aa)
	I79_023268	Disintegrin and metalloproteinase domain-containing protein 17. (527 aa)
	I79_022952	SH3 domain-binding protein 5-like. (81 aa)
	H671_2g4697	SH3 domain-binding protein 5-like. (120 aa)
	I79_022335	SH3 domain-binding protein 5-like. (115 aa)
	Errfi1	ERBB receptor feedback inhibitor 1. (460 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_021564	Pro-epidermal growth factor. (699 aa)
	Areg	Amphiregulin. (230 aa)
	Ereg	Proepiregulin. (162 aa)
	I79_021125	Epigen. (135 aa)
	Nox4	NADPH oxidase 4. (130 aa)
	Socs5	Suppressor of cytokine signaling 5. (530 aa)
	I79_019855	SH3 domain-binding protein 5-like. (120 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Gas6	Growth arrest-specific protein 6. (684 aa)
	I79_019537	Metabotropic glutamate receptor 5. (297 aa)
	Adra2a	Alpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	Tgfa	Protransforming growth factor alpha. (211 aa)
	I79_018661	Metabotropic glutamate receptor 5. (275 aa)
	Ikzf4	Receptor protein-tyrosine kinase. (1902 aa)
	Cblb	E3 ubiquitin-protein ligase CBL-B. (984 aa)
	I79_013004	F-box/WD repeat-containing protein 7. (709 aa)
	I79_012384	Leukocyte common antigen. (962 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adora1	Ghrl	G3H3K9	G3GX43	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Appetite-regulating hormone.	0.737
Agrn	I79_001015	G3I437	G3GTN0	Agrin.	Low-density lipoprotein receptor-related protein 8.	0.588
Agrn	I79_002032	G3I437	G3GWB2	Agrin.	Protein Dok-7.	0.673
Agrn	I79_021564	G3I437	G3ID03	Agrin.	Pro-epidermal growth factor.	0.521
Agt	App	G3GX14	G3HMG4	Angiotensinogen; Belongs to the serpin family.	Amyloid beta A4 protein.	0.456
Agt	Ghrl	G3GX14	G3GX43	Angiotensinogen; Belongs to the serpin family.	Appetite-regulating hormone.	0.560
Agt	H671_4g12667	G3GX14	G3HYG6	Angiotensinogen; Belongs to the serpin family.	Alpha-2-HS-glycoprotein.	0.413
Agt	Ncf1	G3GX14	G3HLN8	Angiotensinogen; Belongs to the serpin family.	Neutrophil cytosol factor 1.	0.414
Agt	Nox4	G3GX14	G3I9V2	Angiotensinogen; Belongs to the serpin family.	NADPH oxidase 4.	0.416
Angpt4	I79_005331	G3H6X9	G3H4W8	Angiopoietin-4.	Receptor tyrosine-protein kinase erbB-4.	0.657
App	Agt	G3HMG4	G3GX14	Amyloid beta A4 protein.	Angiotensinogen; Belongs to the serpin family.	0.456
App	Dlg4	G3HMG4	G3GYA3	Amyloid beta A4 protein.	Disks large-like 4.	0.469
App	I79_001015	G3HMG4	G3GTN0	Amyloid beta A4 protein.	Low-density lipoprotein receptor-related protein 8.	0.562
App	I79_001115	G3HMG4	G3GTX5	Amyloid beta A4 protein.	Amyloid-like protein 2.	0.592
App	I79_008941	G3HMG4	G3HEF7	Amyloid beta A4 protein.	Receptor protein-tyrosine kinase.	0.493
App	I79_023268	G3HMG4	G3IHH8	Amyloid beta A4 protein.	Disintegrin and metalloproteinase domain-containing protein 17.	0.462
App	Ngf	G3HMG4	G3HJF3	Amyloid beta A4 protein.	Beta-nerve growth factor; Belongs to the NGF-beta family.	0.497
App	Prnp	G3HMG4	G3H416	Amyloid beta A4 protein.	Major prion protein; Belongs to the prion family.	0.924
App	Psen1	G3HMG4	G3HNF2	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
App	Psen2	G3HMG4	G3HV76	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.906