(52 nodes) Positive regulation of protein tyrosine kinase activity network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Phf23	Segment polarity protein dishevelled-like DVL-2. (697 aa)
	Dlg4	Disks large-like 4. (216 aa)
	Angpt4	Angiopoietin-4. (499 aa)
	Tal1	T-cell acute lymphocytic leukemia protein 1-like. (329 aa)
	Adora1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	Prnp	Major prion protein; Belongs to the prion family. (254 aa)
	I79_005331	Receptor tyrosine-protein kinase erbB-4. (480 aa)
	I79_005696	p130Cas-associated protein. (1144 aa)
	Pak2	Non-specific serine/threonine protein kinase. (524 aa)
	I79_001015	Low-density lipoprotein receptor-related protein 8. (764 aa)
	I79_002032	Protein Dok-7. (453 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Ghrl	Appetite-regulating hormone. (100 aa)
	Afap1l2	Actin filament-associated protein 1-like 2. (826 aa)
	Unc119	Protein unc-119-like A. (80 aa)
	I79_023268	Disintegrin and metalloproteinase domain-containing protein 17. (527 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_021564	Pro-epidermal growth factor. (699 aa)
	Areg	Amphiregulin. (230 aa)
	Ereg	Proepiregulin. (162 aa)
	I79_021125	Epigen. (135 aa)
	Nox4	NADPH oxidase 4. (130 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Gas6	Growth arrest-specific protein 6. (684 aa)
	I79_019537	Metabotropic glutamate receptor 5. (297 aa)
	Adra2a	Alpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	Tgfa	Protransforming growth factor alpha. (211 aa)
	I79_018661	Metabotropic glutamate receptor 5. (275 aa)
	I79_018306	Ephrin type-A receptor 4. (932 aa)
	Agrn	Agrin. (2036 aa)
	Pdgfb	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
	Dlg3	Disks large-like 3; Belongs to the MAGUK family. (868 aa)
	I79_014973	Pro-neuregulin-2, membrane-bound isoform. (386 aa)
	I79_014451	Pro-neuregulin-1, membrane-bound isoform. (639 aa)
	Nrg1	Pro-neuregulin-1, membrane-bound isoform. (259 aa)
	I79_014053	Abl interactor 1. (280 aa)
	Nedd9	Enhancer of filamentation 1. (830 aa)
	I79_013659	Macrophage colony-stimulating factor 1 receptor. (595 aa)
	Ikzf4	Receptor protein-tyrosine kinase. (1902 aa)
	I79_013004	F-box/WD repeat-containing protein 7. (709 aa)
	Adra1a	Alpha-1A adrenergic receptor. (465 aa)
	Ncf1	Neutrophil cytosol factor 1. (303 aa)
	Ngf	Beta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	Ptpn1	Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	Dgkq	Diacylglycerol kinase. (491 aa)
	Fbxw9	F-box/WD repeat-containing protein 9. (458 aa)
	Efna1	Ephrin-A1; Belongs to the ephrin family. (205 aa)
	Il34	Interleukin-34. (201 aa)
	I79_007090	Receptor tyrosine-protein kinase erbB-4. (182 aa)
	I79_007089	Receptor tyrosine-protein kinase erbB-4. (225 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adora1	Ghrl	G3H3K9	G3GX43	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Appetite-regulating hormone.	0.737
Agrn	I79_001015	G3I437	G3GTN0	Agrin.	Low-density lipoprotein receptor-related protein 8.	0.588
Agrn	I79_002032	G3I437	G3GWB2	Agrin.	Protein Dok-7.	0.673
Agrn	I79_021564	G3I437	G3ID03	Agrin.	Pro-epidermal growth factor.	0.521
Agt	Ghrl	G3GX14	G3GX43	Angiotensinogen; Belongs to the serpin family.	Appetite-regulating hormone.	0.560
Agt	Ncf1	G3GX14	G3HLN8	Angiotensinogen; Belongs to the serpin family.	Neutrophil cytosol factor 1.	0.414
Agt	Nox4	G3GX14	G3I9V2	Angiotensinogen; Belongs to the serpin family.	NADPH oxidase 4.	0.416
Angpt4	I79_005331	G3H6X9	G3H4W8	Angiopoietin-4.	Receptor tyrosine-protein kinase erbB-4.	0.657
Areg	Ereg	G3IBU4	G3IBU3	Amphiregulin.	Proepiregulin.	0.985
Areg	I79_005331	G3IBU4	G3H4W8	Amphiregulin.	Receptor tyrosine-protein kinase erbB-4.	0.854
Areg	I79_007089	G3IBU4	G3H9L3	Amphiregulin.	Receptor tyrosine-protein kinase erbB-4.	0.599
Areg	I79_007090	G3IBU4	G3H9L4	Amphiregulin.	Receptor tyrosine-protein kinase erbB-4.	0.599
Areg	I79_008941	G3IBU4	G3HEF7	Amphiregulin.	Receptor protein-tyrosine kinase.	0.879
Areg	I79_014451	G3IBU4	G3HU47	Amphiregulin.	Pro-neuregulin-1, membrane-bound isoform.	0.446
Areg	I79_014973	G3IBU4	G3HVI4	Amphiregulin.	Pro-neuregulin-2, membrane-bound isoform.	0.416
Areg	I79_021125	G3IBU4	G3IBU2	Amphiregulin.	Epigen.	0.859
Areg	I79_021564	G3IBU4	G3ID03	Amphiregulin.	Pro-epidermal growth factor.	0.777
Areg	I79_023268	G3IBU4	G3IHH8	Amphiregulin.	Disintegrin and metalloproteinase domain-containing protein 17.	0.455
Areg	Ikzf4	G3IBU4	G3HRK1	Amphiregulin.	Receptor protein-tyrosine kinase.	0.765
Areg	Tgfa	G3IBU4	G3I6E7	Amphiregulin.	Protransforming growth factor alpha.	0.732