(58 nodes) Regulation of lymphocyte apoptotic process network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Lgals3	Galectin. (281 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	Il10	Interleukin-10. (178 aa)
	Gimap8	GTPase IMAP family member 8. (610 aa)
	Efna1	Ephrin-A1; Belongs to the ephrin family. (205 aa)
	I79_008528	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (497 aa)
	Ido1	Indoleamine 2,3-dioxygenase 1. (567 aa)
	I79_009874	Baculoviral IAP repeat-containing protein 7. (196 aa)
	Bcl11b	B-cell lymphoma/leukemia 11B. (812 aa)
	I79_011181	Interleukin-7 receptor subunit alpha. (257 aa)
	Pip	Prolactin-inducible protein-like. (78 aa)
	Ada	Adenosine deaminase. (363 aa)
	I79_012691	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase; Belongs to the glycosyltransferase 29 family. (208 aa)
	Slc46a2	Thymic stromal cotransporter protein. (436 aa)
	I79_012741	Kinesin-associated protein 3. (610 aa)
	Nfkbid	NF-kappa-B inhibitor delta. (74 aa)
	Fadd	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	Cd74	H-2 class II histocompatibility antigen gamma chain. (329 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Pdcd7	Programmed cell death protein 7. (196 aa)
	Hif1a	Hypoxia-inducible factor 1 alpha. (820 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	I79_017561	Tyrosine-protein kinase Lyn. (101 aa)
	I79_018586	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
	I79_018849	Serine/threonine-protein kinase D2. (513 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Adam8	Disintegrin and metalloproteinase domain-containing protein 8. (936 aa)
	I79_020697	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (980 aa)
	I79_021840	Nuclear receptor ROR-gamma. (341 aa)
	Slc39a10	Zinc transporter ZIP10. (791 aa)
	Blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (464 aa)
	I79_023244	Bloom syndrome protein-like. (721 aa)
	I79_023818	Dedicator of cytokinesis protein 8; Belongs to the DOCK family. (1309 aa)
	Noc2l	Putative nucleolar complex protein 2 like protein. (748 aa)
	Irs2	Insulin receptor substrate 2. (465 aa)
	H671_2g7682	PRELI domain-containing protein 1, mitochondrial. (93 aa)
	Bcl10	B-cell lymphoma/leukemia 10. (232 aa)
	Dock8	Dedicator of cytokinesis protein 8. (73 aa)
	I79_025546	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase; Belongs to the glycosyltransferase 29 family. (340 aa)
	Ormdl3	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	I79_000010	Protein kinase C. (566 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Foxp1	Forkhead box protein P1. (696 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Vhl	Von Hippel-Lindau disease tumor suppressor. (134 aa)
	I79_003373	Fas apoptotic inhibitory molecule 3. (326 aa)
	Zc3h8	Zinc finger CCCH domain-containing protein 8. (306 aa)
	Blk	Tyrosine-protein kinase. (500 aa)
	Prelid1	PRELI domain-containing protein 1, mitochondrial. (156 aa)
	Arg2	Arginase. (305 aa)
	I79_004285	p2X purinoceptor 7. (805 aa)
	Siglec1	Sialoadhesin. (1708 aa)
	I79_005129	Tyrosine-protein kinase JAK3. (330 aa)
	Jak3	Tyrosine-protein kinase JAK3. (222 aa)
	Hsh2d	Hematopoietic SH2 domain-containing protein. (336 aa)
	Fnip1	Folliculin-interacting protein 1. (1435 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ada	Arg2	G3HLR7	G3H1L8	Adenosine deaminase.	Arginase.	0.416
Ada	IL2	G3HLR7	G3HTL8	Adenosine deaminase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.584
Adam8	Ormdl3	G3IAM7	G3INW0	Disintegrin and metalloproteinase domain-containing protein 8.	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.607
Arg2	Ada	G3H1L8	G3HLR7	Arginase.	Adenosine deaminase.	0.416
Arg2	Il10	G3H1L8	G3HB01	Arginase.	Interleukin-10.	0.754
Bcl10	Casp8	G3IMU1	B2CMK5	B-cell lymphoma/leukemia 10.	Caspase-8; Belongs to the peptidase C14A family.	0.972
Bcl10	Fadd	G3IMU1	G3HQ71	B-cell lymphoma/leukemia 10.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.495
Bcl10	I79_000010	G3IMU1	G3GR67	B-cell lymphoma/leukemia 10.	Protein kinase C.	0.803
Blk	I79_018586	G3H0L5	G3I540	Tyrosine-protein kinase.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.436
Blm	I79_023244	G3IG14	G3IHF5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Bloom syndrome protein-like.	0.854
Casp8	Bcl10	B2CMK5	G3IMU1	Caspase-8; Belongs to the peptidase C14A family.	B-cell lymphoma/leukemia 10.	0.972
Casp8	Fadd	B2CMK5	G3HQ71	Caspase-8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
Casp8	I79_008528	B2CMK5	G3HDI2	Caspase-8; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily.	0.984
Casp8	I79_009874	B2CMK5	G3HGY0	Caspase-8; Belongs to the peptidase C14A family.	Baculoviral IAP repeat-containing protein 7.	0.452
Ccl5	IL2	G3I8B1	G3HTL8	C-C motif chemokine.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.562
Ccl5	Il10	G3I8B1	G3HB01	C-C motif chemokine.	Interleukin-10.	0.855
Ccl5	Lgals3	G3I8B1	G3H7B3	C-C motif chemokine.	Galectin.	0.566
Fadd	Bcl10	G3HQ71	G3IMU1	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	B-cell lymphoma/leukemia 10.	0.495
Fadd	Casp8	G3HQ71	B2CMK5	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase-8; Belongs to the peptidase C14A family.	0.999
Fadd	I79_008528	G3HQ71	G3HDI2	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily.	0.979