(100 nodes) Response to interleukin-1 network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (560 aa)
	Ccl22	C-C motif chemokine. (93 aa)
	Cx3cl1	Fractalkine. (335 aa)
	Ccl17	C-C motif chemokine. (93 aa)
	Adamts12	A disintegrin and metalloproteinase with thrombospondin motifs 12. (171 aa)
	I79_010524	A disintegrin and metalloproteinase with thrombospondin motifs 12. (1148 aa)
	I79_010620	Alpha-synuclein; Belongs to the synuclein family. (166 aa)
	Gclc	Glutamate--cysteine ligase catalytic subunit. (584 aa)
	Camp	Cathelin-related antimicrobial peptide. (108 aa)
	App	Amyloid beta A4 protein. (433 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	Ripk2	Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Map2k7	Dual specificity mitogen-activated protein kinase kinase 7. (391 aa)
	I79_013820	Amino-terminal enhancer of split. (175 aa)
	Cactin	Uncharacterized protein C19orf29-like. (425 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	Ythdc2	Putative ATP-dependent RNA helicase YTHDC2. (1268 aa)
	I79_015063	Suppression of tumorigenicity protein 18. (780 aa)
	I79_015109	Interleukin-6. (174 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Dab2ip	Disabled-like 2-interacting protein. (1065 aa)
	Hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
	Hif1a	Hypoxia-inducible factor 1 alpha. (820 aa)
	Mapk13	Mitogen-activated protein kinase. (278 aa)
	Tnip2	TNFAIP3-interacting protein 2. (431 aa)
	Il17a	Interleukin-17A. (158 aa)
	H671_2g5865	Histamine N-methyltransferase-like protein. (320 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Sirpa	Tyrosine-protein phosphatase non-receptor type substrate 1. (522 aa)
	I79_017129	TRAF family member-associated NF-kappa-B activator. (427 aa)
	I79_025944	Hyaluronan synthase 2. (151 aa)
	Has2	Hyaluronan synthase 2. (337 aa)
	I79_025745	Nuclear receptor subfamily 1 group D member 1. (226 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Nfkb1	Nuclear factor NF-kappa-B p105 subunit. (509 aa)
	I79_025482	Nuclear factor NF-kappa-B p105 subunit. (144 aa)
	Smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (593 aa)
	I79_024962	Uncharacterized protein C19orf29-like. (171 aa)
	I79_024961	Uncharacterized protein C19orf29-like. (328 aa)
	Rps6ka4	Ribosomal protein S6 kinase alpha-4. (254 aa)
	I79_024393	Cofilin-1. (85 aa)
	Mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (644 aa)
	Rora	Nuclear receptor ROR-alpha. (959 aa)
	Rela	Transcription factor p65. (546 aa)
	Cfl1	Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
	Ghr	Growth hormone receptor. (345 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	I79_019425	Apoptosis-associated speck-like protein containing a CARD. (192 aa)
	Epo	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	CgPICR_003404	C-C motif chemokine. (92 aa)
	CgPICR_003405	C-C motif chemokine. (98 aa)
	Nr1d1	Nuclear receptor subfamily 1 group D member 1. (508 aa)
	Anxa1	Annexin. (346 aa)
	Tollip	Toll-interacting protein. (274 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	Trim63	E3 ubiquitin-protein ligase TRIM63. (355 aa)
	I79_000233	Cytochrome b-245 light chain. (206 aa)
	Usp10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (772 aa)
	I79_000439	Phosphoinositide phospholipase C. (949 aa)
	Adamts7	A disintegrin and metalloproteinase with thrombospondin motifs 7. (916 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	CgPICR_003438	C-C motif chemokine. (143 aa)
	I79_001072	C-C motif chemokine. (97 aa)
	I79_001073	C-C motif chemokine. (72 aa)
	Ccl1	C-C motif chemokine 1. (91 aa)
	Akap12	A-kinase anchor protein 12. (837 aa)
	Irak2	Interleukin-1 receptor-associated kinase-like 2. (626 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	I79_002662	Interleukin-1 receptor-associated kinase 3. (537 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Serpinc1	Roquin; Belongs to the serpin family. (1418 aa)
	Slc30a8	Zinc transporter 8. (285 aa)
	Edn1	Endothelin-1. (202 aa)
	Mmp2	72 kDa type IV collagenase. (662 aa)
	I79_017896	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (427 aa)
	I79_017749	Mitogen-activated protein kinase 11. (413 aa)
	Fn1	Fibronectin. (2486 aa)
	Chi3l1	Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (719 aa)
	Ankrd1	Ankyrin repeat domain-containing protein 1. (319 aa)
	Upf1	Regulator of nonsense transcripts 1. (771 aa)
	I79_005503	Polycomb complex protein BMI-1. (324 aa)
	Fgb	Fibrinogen beta chain. (407 aa)
	Il1r1	Interleukin-1 receptor type I. (572 aa)
	I79_006180	Neuroendocrine convertase 1; Belongs to the peptidase S8 family. (627 aa)
	Hyal2	Hyaluronidase. (359 aa)
	Cd40	Tumor necrosis factor receptor superfamily member 5. (118 aa)
	Serpine1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (270 aa)
	I79_007297	Plasminogen activator inhibitor 1; Belongs to the serpin family. (108 aa)
	Pck1	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
	Cd47	Leukocyte surface antigen CD47. (268 aa)
	I79_008485	Cofilin-1; Belongs to the actin-binding proteins ADF family. (111 aa)
	Zc3h12a	Ribonuclease ZC3H12A. (577 aa)
	I79_008828	Lymphotactin. (114 aa)
	Ptgis	Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
	Egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
	I79_010095	Inhibitor of nuclear factor kappa-B kinase subunit beta. (408 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	Acod1	Immune-responsive gene 1 protein. (290 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acod1	IL1B	G3HI30	G3I1B0	Immune-responsive gene 1 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.406
Acod1	Mthfr	G3HI30	G3IHM4	Immune-responsive gene 1 protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.532
Adamts12	Adamts7	G3HIP8	G3GTA4	A disintegrin and metalloproteinase with thrombospondin motifs 12.	A disintegrin and metalloproteinase with thrombospondin motifs 7.	0.817
Adamts7	Adamts12	G3GTA4	G3HIP8	A disintegrin and metalloproteinase with thrombospondin motifs 7.	A disintegrin and metalloproteinase with thrombospondin motifs 12.	0.817
Ankrd1	Rela	G3H3V2	G3IDM9	Ankyrin repeat domain-containing protein 1.	Transcription factor p65.	0.407
Anxa1	App	G3I5L3	G3HMG4	Annexin.	Amyloid beta A4 protein.	0.545
Anxa1	IL1B	G3I5L3	G3I1B0	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.500
App	Anxa1	G3HMG4	G3I5L3	Amyloid beta A4 protein.	Annexin.	0.545
App	Edn1	G3HMG4	G3H0G9	Amyloid beta A4 protein.	Endothelin-1.	0.455
App	I79_000439	G3HMG4	G3GSB8	Amyloid beta A4 protein.	Phosphoinositide phospholipase C.	0.442
App	I79_010620	G3HMG4	G3HIY8	Amyloid beta A4 protein.	Alpha-synuclein; Belongs to the synuclein family.	0.812
App	I79_015109	G3HMG4	G3HVW6	Amyloid beta A4 protein.	Interleukin-6.	0.432
App	I79_025482	G3HMG4	G3ING1	Amyloid beta A4 protein.	Nuclear factor NF-kappa-B p105 subunit.	0.488
App	IL1B	G3HMG4	G3I1B0	Amyloid beta A4 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.487
App	Nfkb1	G3HMG4	G3INJ4	Amyloid beta A4 protein.	Nuclear factor NF-kappa-B p105 subunit.	0.488
App	Src	G3HMG4	G3GXX7	Amyloid beta A4 protein.	Tyrosine-protein kinase.	0.402
Cactin	I79_024961	G3HSK4	G3IM31	Uncharacterized protein C19orf29-like.	Uncharacterized protein C19orf29-like.	0.918
Camp	Nfkb1	G3HKQ4	G3INJ4	Cathelin-related antimicrobial peptide.	Nuclear factor NF-kappa-B p105 subunit.	0.918
Camp	Rela	G3HKQ4	G3IDM9	Cathelin-related antimicrobial peptide.	Transcription factor p65.	0.930
Ccl1	Ccl17	G3GTT6	G3HIL3	C-C motif chemokine 1.	C-C motif chemokine.	0.747