(86 nodes) Negative regulation of leukocyte proliferation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_019973	Disks large-like 5. (219 aa)
	I79_020009	Phosphodiesterase. (597 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	I79_020667	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (256 aa)
	I79_021445	Disks large-like 5. (294 aa)
	I79_021446	Disks large-like 5. (133 aa)
	I79_021447	Disks large-like 5. (129 aa)
	I79_021448	Disks large-like 5. (270 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_021890	Disks large-like 5. (101 aa)
	I79_022023	Arginase-1; Belongs to the arginase family. (281 aa)
	I79_022205	Disks large-like 5. (99 aa)
	Tnfrsf14	Tumor necrosis factor receptor superfamily member 14. (184 aa)
	Jhy	Cytotoxic and regulatory T-cell molecule. (334 aa)
	Inpp5d	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
	I79_024446	Disks large-like 5. (162 aa)
	I79_024447	Disks large-like 5. (99 aa)
	I79_025180	Disks large-like 5. (144 aa)
	I79_025338	Disks large-like 5. (203 aa)
	Bcl6	B-cell lymphoma 6 protein-like. (707 aa)
	I79_000959	CMRF35-like molecule 8. (295 aa)
	I79_001043	Galectin. (94 aa)
	I79_001046	Neurofibromin. (2164 aa)
	Ptpn6	Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
	Mad1l1	Mitotic spindle assembly checkpoint protein MAD1. (717 aa)
	Dlg5	Disks large-like 5; Belongs to the MAGUK family. (1873 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4. (171 aa)
	Serpinc1	Roquin; Belongs to the serpin family. (1418 aa)
	Blk	Tyrosine-protein kinase. (500 aa)
	Peli1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	Arg2	Arginase. (305 aa)
	Laptm5	Lysosomal-associated transmembrane protein 5. (232 aa)
	Zc3h12d	Putative ribonuclease ZC3H12D. (549 aa)
	Prnp	Major prion protein; Belongs to the prion family. (254 aa)
	Tmem131l	Transmembrane protein 131-like. (1533 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	Crp	Pentaxin. (225 aa)
	Prkar1a	cAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
	Marchf7	E3 ubiquitin-protein ligase MARCH7. (704 aa)
	Vtcn1	V-set domain containing T-cell activation inhibitor 1. (206 aa)
	Cd86	T-lymphocyte activation antigen CD86. (269 aa)
	Itch	E3 ubiquitin-protein ligase. (851 aa)
	Rassf5	Ras association domain-containing protein 5. (246 aa)
	Il10	Interleukin-10. (178 aa)
	Zbtb7b	Zinc finger and BTB domain-containing protein 7B. (543 aa)
	Pkn1	Serine/threonine-protein kinase N1; Belongs to the G-protein coupled receptor 2 family. (1696 aa)
	I79_008672	Butyrophilin subfamily 1 member A1. (719 aa)
	I79_008828	Lymphotactin. (114 aa)
	Glmn	Glomulin. (287 aa)
	Cd276	CD276 antigen. (316 aa)
	I79_009416	Serine-protein kinase ATM. (1640 aa)
	Ido1	Indoleamine 2,3-dioxygenase 1. (567 aa)
	I79_010622	Leucine-rich repeat-containing protein 1. (119 aa)
	Lrrc1	Leucine-rich repeat-containing protein 1. (167 aa)
	Sdc4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	I79_012901	Pulmonary surfactant-associated protein D. (335 aa)
	I79_013190	Ig-like domain-containing protein; Belongs to the MHC class II family. (206 aa)
	Cblb	E3 ubiquitin-protein ligase CBL-B. (984 aa)
	I79_013795	Disks large-like 5. (96 aa)
	Tnfrsf21	Tumor necrosis factor receptor superfamily member 21. (654 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Foxj1	Forkhead box protein J1. (421 aa)
	Pla2g2d	Phospholipase A(2). (118 aa)
	Pla2g2f	Phospholipase A(2). (176 aa)
	Gpnmb	Transmembrane glycoprotein NMB. (610 aa)
	Ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
	I79_015381	Protein scribble-like. (789 aa)
	I79_015484	C-type lectin domain family 4 member G. (399 aa)
	I79_015910	Tetraspanin-32. (158 aa)
	I79_016311	PRKC apoptosis WT1 regulator protein. (214 aa)
	Twsg1	Twisted gastrulation protein-like 1. (222 aa)
	I79_016810	Serine-protein kinase ATM. (473 aa)
	I79_016874	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2. (92 aa)
	Cd80	T-lymphocyte activation antigen CD80. (177 aa)
	Vsir	Platelet receptor Gi24. (271 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	I79_017561	Tyrosine-protein kinase Lyn. (101 aa)
	Il33	Interleukin-33. (217 aa)
	I79_018593	Disks large-like 5. (121 aa)
	I79_018655	Galanin. (198 aa)
	Il4i1	L-amino-acid oxidase. (413 aa)
	I79_019300	L-amino-acid oxidase. (112 aa)
	I79_025450	Disks large-like 5. (167 aa)
	I79_025487	Disks large-like 5. (92 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arg2	Il10	G3H1L8	G3HB01	Arginase.	Interleukin-10.	0.754
Arg2	Il33	G3H1L8	G3I4V3	Arginase.	Interleukin-33.	0.483
Bcl6	Cd80	G3GT91	G3I1J7	B-cell lymphoma 6 protein-like.	T-lymphocyte activation antigen CD80.	0.676
Bcl6	Cd86	G3GT91	G3HAJ6	B-cell lymphoma 6 protein-like.	T-lymphocyte activation antigen CD86.	0.733
Bcl6	Ctla4	G3GT91	G3GYW4	B-cell lymphoma 6 protein-like.	Cytotoxic T-lymphocyte protein 4.	0.516
Bcl6	Foxp3	G3GT91	G3HNB1	B-cell lymphoma 6 protein-like.	Forkhead box protein P3.	0.763
Bcl6	IL2	G3GT91	G3HTL8	B-cell lymphoma 6 protein-like.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.428
Bcl6	Il10	G3GT91	G3HB01	B-cell lymphoma 6 protein-like.	Interleukin-10.	0.412
Blk	Cblb	G3H0L5	G3HRG2	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL-B.	0.529
Blk	Ptpn6	G3H0L5	G3GUQ5	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type 6.	0.413
Cblb	Blk	G3HRG2	G3H0L5	E3 ubiquitin-protein ligase CBL-B.	Tyrosine-protein kinase.	0.529
Cblb	I79_017561	G3HRG2	G3I2D2	E3 ubiquitin-protein ligase CBL-B.	Tyrosine-protein kinase Lyn.	0.786
Cblb	Itch	G3HRG2	G3HAN9	E3 ubiquitin-protein ligase CBL-B.	E3 ubiquitin-protein ligase.	0.926
Cblb	Lyn	G3HRG2	G3I2D1	E3 ubiquitin-protein ligase CBL-B.	Tyrosine-protein kinase.	0.786
Cblb	Ptpn6	G3HRG2	G3GUQ5	E3 ubiquitin-protein ligase CBL-B.	Tyrosine-protein phosphatase non-receptor type 6.	0.644
Cd276	Cd80	G3HEI9	G3I1J7	CD276 antigen.	T-lymphocyte activation antigen CD80.	0.684
Cd276	Cd86	G3HEI9	G3HAJ6	CD276 antigen.	T-lymphocyte activation antigen CD86.	0.664
Cd276	Ctla4	G3HEI9	G3GYW4	CD276 antigen.	Cytotoxic T-lymphocyte protein 4.	0.732
Cd276	Foxp3	G3HEI9	G3HNB1	CD276 antigen.	Forkhead box protein P3.	0.434
Cd276	IL2	G3HEI9	G3HTL8	CD276 antigen.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.513