STRINGSTRING
Zp3 Zp3 Il12rb1 Il12rb1 I79_025434 I79_025434 I79_025313 I79_025313 I79_025274 I79_025274 Kit Kit I79_024695 I79_024695 Itgal Itgal Irs2 Irs2 I79_024097 I79_024097 Nfatc2 Nfatc2 I79_023926 I79_023926 I79_023475 I79_023475 Csf1 Csf1 I79_023364 I79_023364 I79_023244 I79_023244 Blm Blm I79_022639 I79_022639 I79_022515 I79_022515 Jak2 Jak2 I79_021950 I79_021950 Slc39a10 Slc39a10 Rps3 Rps3 Cd46 Cd46 Vcam1 Vcam1 Efnb1 Efnb1 Tnfrsf13c Tnfrsf13c I79_020697 I79_020697 I79_020316 I79_020316 Ccl5 Ccl5 Ptk2 Ptk2 I79_019425 I79_019425 I79_019038 I79_019038 I79_018994 I79_018994 I79_018993 I79_018993 Epo Epo CgPICR_011244 CgPICR_011244 Cd320 Cd320 Anxa1 Anxa1 Mapk3 Mapk3 I79_018349 I79_018349 Clcf1 Clcf1 I79_017561 I79_017561 Lyn Lyn I79_017540 I79_017540 Cd80 Cd80 IL1B IL1B Tlr4 Tlr4 Pth Pth Flt3lg Flt3lg I79_016534 I79_016534 Aif1 Aif1 I79_016423 I79_016423 Ager Ager St6gal1 St6gal1 I79_015916 I79_015916 Cd81 Cd81 I79_015503 I79_015503 CgPICR_014700 CgPICR_014700 I79_015109 I79_015109 IL2 IL2 Il21 Il21 Dnaja3 Dnaja3 Cd74 Cd74 I79_013659 I79_013659 Il23a Il23a Myd88 Myd88 I79_013183 I79_013183 H671_1g3220 H671_1g3220 Fadd Fadd Ripk2 Ripk2 H671_3g9571 H671_3g9571 I79_012384 I79_012384 Foxp3 Foxp3 Ccl19 Ccl19 I79_011712 I79_011712 I79_011711 I79_011711 Ada Ada Slc4a1 Slc4a1 I79_011202 I79_011202 Cdkn1a Cdkn1a Il15 Il15 Ephb2 Ephb2 Kitlg Kitlg Syk Syk Il6st Il6st I79_010136 I79_010136 Gpr183 Gpr183 I79_009500 I79_009500 I79_009350 I79_009350 Mpl Mpl Tcf3 Tcf3 Nck1 Nck1 Cd276 Cd276 I79_008828 I79_008828 IL12B IL12B H671_3g9841 H671_3g9841 Dhps Dhps Tnfsf9 Tnfsf9 Ticam1 Ticam1 Chrnb2 Chrnb2 Mef2c Mef2c Nmbr Nmbr Cd86 Cd86 Gsk3b Gsk3b Il34 Il34 Vtcn1 Vtcn1 Znf335 Znf335 Cd40 Cd40 Ocstamp Ocstamp I79_006517 I79_006517 I79_006470 I79_006470 I79_006225 I79_006225 I79_005999 I79_005999 I79_005968 I79_005968 Tyk2 Tyk2 Igf1 Igf1 Nck2 Nck2 I79_005503 I79_005503 Csf2 Csf2 Jak3 Jak3 I79_005129 I79_005129 I79_005113 I79_005113 Igfbp2 Igfbp2 Il18 Il18 I79_004087 I79_004087 Peli1 Peli1 Tacr1 Tacr1 I79_003362 I79_003362 Tnfsf4 Tnfsf4 Tlr9 Tlr9 Lep Lep Traf6 Traf6 Cd28 Cd28 Adk Adk Slc7a1 Slc7a1 I79_001680 I79_001680 Tgfbr2 Tgfbr2 Selenok Selenok Cd4 Cd4 Atad5 Atad5 I79_001029 I79_001029 Bcl6 Bcl6 Tfrc Tfrc I79_000010 I79_000010
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Zp3Zona pellucida sperm-binding protein 3. (403 aa)
Il12rb1Interleukin-12 receptor beta-1 chain. (183 aa)
I79_025434Interleukin-3 receptor class 2 beta chain. (355 aa)
I79_025313Cytokine receptor common subunit beta. (71 aa)
I79_025274Integrin alpha-L. (331 aa)
KitMast/stem cell growth factor receptor. (452 aa)
I79_024695Butyrophilin-like protein 2. (415 aa)
ItgalIntegrin alpha-L; Belongs to the integrin alpha chain family. (699 aa)
Irs2Insulin receptor substrate 2. (465 aa)
I79_024097Vascular cell adhesion protein 1. (225 aa)
Nfatc2Nuclear factor of activated T-cells, cytoplasmic 2. (602 aa)
I79_023926Nuclear factor of activated T-cells, cytoplasmic 2. (129 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
I79_023364Cytokine receptor common subunit beta. (710 aa)
I79_023244Bloom syndrome protein-like. (721 aa)
BlmATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (464 aa)
I79_022639ADP-ribosyl cyclase 2. (261 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_021950T-cell differentiation antigen CD6. (536 aa)
Slc39a10Zinc transporter ZIP10. (791 aa)
Rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (117 aa)
Cd46Membrane cofactor protein. (280 aa)
Vcam1Vascular cell adhesion protein 1. (220 aa)
Efnb1Ephrin-B1; Belongs to the ephrin family. (343 aa)
Tnfrsf13cTumor necrosis factor receptor superfamily member 13C. (162 aa)
I79_020697Glycerol-3-phosphate acyltransferase 1, mitochondrial. (980 aa)
I79_020316Guanine nucleotide exchange factor VAV3. (604 aa)
Ccl5C-C motif chemokine. (91 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
I79_019425Apoptosis-associated speck-like protein containing a CARD. (192 aa)
I79_019038Nck-associated protein 1-like. (1065 aa)
I79_018994Interleukin-12 receptor beta-2 chain. (358 aa)
I79_018993Interleukin-23 receptor. (380 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
CgPICR_01124440S ribosomal protein S3. (94 aa)
Cd320CD320 antigen. (200 aa)
Anxa1Annexin. (346 aa)
Mapk3Mitogen-activated protein kinase. (408 aa)
I79_018349Coronin-1A. (143 aa)
Clcf1Cardiotrophin-like cytokine factor 1. (225 aa)
I79_017561Tyrosine-protein kinase Lyn. (101 aa)
LynTyrosine-protein kinase. (289 aa)
I79_017540Selenoprotein K. (100 aa)
Cd80T-lymphocyte activation antigen CD80. (177 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
PthParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (114 aa)
Flt3lgSL cytokine. (230 aa)
I79_016534Leucine-rich repeat-containing protein 16C. (1178 aa)
Aif1Allograft inflammatory factor 1. (80 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
St6gal1Beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (402 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Cd81Tetraspanin. (236 aa)
I79_015503Transcription factor HES-1. (92 aa)
CgPICR_014700C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
I79_015109Interleukin-6. (174 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Il21Interleukin-21. (67 aa)
Dnaja3DnaJ-like subfamily A member 3, mitochondrial. (453 aa)
Cd74H-2 class II histocompatibility antigen gamma chain. (329 aa)
I79_013659Macrophage colony-stimulating factor 1 receptor. (595 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
I79_013183Class II histocompatibility antigen, M beta 1 chain. (261 aa)
H671_1g3220HLA class II histocompatibility antigen, DP beta 1 chain-like protein. (280 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
H671_3g9571Zona pellucida sperm-binding protein 4. (454 aa)
I79_012384Leukocyte common antigen. (962 aa)
Foxp3Forkhead box protein P3. (428 aa)
Ccl19C-C motif chemokine. (117 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
AdaAdenosine deaminase. (363 aa)
Slc4a1Anion exchange protein. (915 aa)
I79_011202T-cell surface glycoprotein CD1d1. (111 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (163 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Ephb2Ephrin type-B receptor 2. (1018 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SykTyrosine-protein kinase. (611 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
I79_010136Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
Gpr183G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
I79_009500Mitogen-activated protein kinase 1. (68 aa)
I79_009350Toll/interleukin-1 receptor domain-containing adapter protein. (245 aa)
MplThrombopoietin receptor. (647 aa)
Tcf3Transcription factor E2-alpha. (643 aa)
Nck1Cytoplasmic protein NCK1. (602 aa)
Cd276CD276 antigen. (316 aa)
I79_008828Lymphotactin. (114 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
H671_3g9841Interleukin-27 receptor subunit alpha. (566 aa)
DhpsDeoxyhypusine synthase-like isoform 1. (369 aa)
Tnfsf9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (307 aa)
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (699 aa)
Chrnb2Neuronal acetylcholine receptor subunit beta-2. (495 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
NmbrNeuromedin-B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
Cd86T-lymphocyte activation antigen CD86. (269 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Il34Interleukin-34. (201 aa)
Vtcn1V-set domain containing T-cell activation inhibitor 1. (206 aa)
Znf335Zinc finger protein 335. (1171 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
OcstampTransmembrane protein C20orf123-like. (519 aa)
I79_006517Spectrin alpha chain, erythrocyte. (181 aa)
I79_006470Natural killer cell receptor 2B4. (280 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_005999Spectrin alpha chain, erythrocyte. (326 aa)
I79_005968CD40 ligand; Belongs to the tumor necrosis factor family. (219 aa)
Tyk2Tyrosine-protein kinase. (1182 aa)
Igf1Insulin-like growth factor I. (75 aa)
Nck2Cytoplasmic protein. (380 aa)
I79_005503Polycomb complex protein BMI-1. (324 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (95 aa)
Jak3Tyrosine-protein kinase JAK3. (222 aa)
I79_005129Tyrosine-protein kinase JAK3. (330 aa)
I79_005113Interleukin-12 receptor beta-1 chain. (585 aa)
Igfbp2Insulin-like growth factor-binding protein 2. (177 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
I79_004087Tyrosine-protein kinase. (593 aa)
Peli1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
I79_003362Complement decay-accelerating factor. (157 aa)
Tnfsf4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
Tlr9Toll-like receptor 9. (1239 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
Cd28T-cell-specific surface glycoprotein CD28. (100 aa)
AdkAdenosine kinase. (361 aa)
Slc7a1High affinity cationic amino acid transporter 1. (628 aa)
I79_001680Caspase recruitment domain-containing protein 11. (1089 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SelenokSelenoprotein K. (91 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Atad5ATPase family AAA domain-containing protein 5. (1335 aa)
I79_001029Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (277 aa)
Bcl6B-cell lymphoma 6 protein-like. (707 aa)
TfrcTransferrin receptor protein 1. (757 aa)
I79_000010Protein kinase C. (566 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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