(45 nodes) Cellular response to dexamethasone stimulus network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_020539	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
	I79_021361	UPF0567 protein C13orf39-like. (252 aa)
	I79_022023	Arginase-1; Belongs to the arginase family. (281 aa)
	I79_022055	Argininosuccinate synthase. (97 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	Errfi1	ERBB receptor feedback inhibitor 1. (460 aa)
	Eif4e	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
	Mstn	Growth/differentiation factor 8. (295 aa)
	Serpinf1	Pigment epithelium-derived factor; Belongs to the serpin family. (94 aa)
	Ass1	Argininosuccinate synthase. (242 aa)
	Fbxo32	F-box only protein 32. (101 aa)
	I79_026091	Pigment epithelium-derived factor; Belongs to the serpin family. (58 aa)
	Nr3c1	Glucocorticoid receptor. (748 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	Pck2	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
	Srd5a1	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
	Pck1	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
	Atp5f1a	ATP synthase subunit alpha, mitochondrial. (285 aa)
	I79_007391	ATP synthase subunit alpha, mitochondrial. (65 aa)
	Gjb2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
	Axin2	Axin-2. (809 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_005503	Polycomb complex protein BMI-1. (324 aa)
	Eif4ebp1	Eukaryotic translation initiation factor 4E-binding protein 1. (117 aa)
	Usp8	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1075 aa)
	Ifnb1	Interferon beta. (182 aa)
	I79_002251	Type-1 angiotensin II receptor. (117 aa)
	CgPICR_003438	C-C motif chemokine. (143 aa)
	I79_006368	SET and MYND domain-containing protein 3. (87 aa)
	Smyd3	SET and MYND domain-containing protein 3. (239 aa)
	Hnrnpu	Heterogeneous nuclear ribonucleoprotein U. (512 aa)
	Dkk4	Salivary plasminogen activator alpha 2. (675 aa)
	Rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
	Aqp1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	Igf1r	Insulin-like growth factor 1 receptor. (191 aa)
	Tfap4	Transcription factor AP-4. (338 aa)
	Cflar	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (484 aa)
	Foxo1	Forkhead box protein O1. (469 aa)
	Agtr1	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	Ddit4	DNA-damage-inducible transcript 4 protein. (231 aa)
	Trim63	E3 ubiquitin-protein ligase TRIM63. (355 aa)
	Agtr2	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Agtr1	Agtr2	G3I0U1	G3I4R1	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	0.962
Agtr2	Agtr1	G3I4R1	G3I0U1	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	0.962
Agtr2	I79_002251	G3I4R1	G3GWW6	Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family.	Type-1 angiotensin II receptor.	0.636
Ass1	Atp5f1a	G3IMU3	G3HAE3	Argininosuccinate synthase.	ATP synthase subunit alpha, mitochondrial.	0.605
Ass1	I79_007391	G3IMU3	G3HAE2	Argininosuccinate synthase.	ATP synthase subunit alpha, mitochondrial.	0.605
Ass1	I79_022023	G3IMU3	G3IE79	Argininosuccinate synthase.	Arginase-1; Belongs to the arginase family.	0.524
Ass1	I79_022055	G3IMU3	G3IEB0	Argininosuccinate synthase.	Argininosuccinate synthase.	0.951
Atp5f1a	Ass1	G3HAE3	G3IMU3	ATP synthase subunit alpha, mitochondrial.	Argininosuccinate synthase.	0.605
Atp5f1a	I79_022055	G3HAE3	G3IEB0	ATP synthase subunit alpha, mitochondrial.	Argininosuccinate synthase.	0.605
Atp5f1a	Rps6kb1	G3HAE3	G3HJ94	ATP synthase subunit alpha, mitochondrial.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.446
CgPICR_003438	I79_022023	G3GTT2	G3IE79	C-C motif chemokine.	Arginase-1; Belongs to the arginase family.	0.407
CgPICR_003438	Tgfb1	G3GTT2	G3IA12	C-C motif chemokine.	Transforming growth factor beta-1.	0.584
Dkk4	I79_026091	G3HHH6	G3IQ06	Salivary plasminogen activator alpha 2.	Pigment epithelium-derived factor; Belongs to the serpin family.	0.431
Dkk4	Serpinf1	G3HHH6	G3IKX2	Salivary plasminogen activator alpha 2.	Pigment epithelium-derived factor; Belongs to the serpin family.	0.431
Eif4e	Eif4ebp1	G3IIH3	G3H1G2	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4E-binding protein 1.	0.996
Eif4e	Rps6kb1	G3IIH3	G3HJ94	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.504
Eif4ebp1	Eif4e	G3H1G2	G3IIH3	Eukaryotic translation initiation factor 4E-binding protein 1.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.996
Eif4ebp1	I79_020539	G3H1G2	G3IAB9	Eukaryotic translation initiation factor 4E-binding protein 1.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.964
Eif4ebp1	Rps6kb1	G3H1G2	G3HJ94	Eukaryotic translation initiation factor 4E-binding protein 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.565
Fbxo32	Foxo1	G3IPL9	G3HZV8	F-box only protein 32.	Forkhead box protein O1.	0.541