STRINGSTRING
Gata3 Gata3 Heyl Heyl I79_012218 I79_012218 Rgmb Rgmb Notch2 Notch2 Bmp15 Bmp15 Smad7 Smad7 Acvr2b Acvr2b Slc39a5 Slc39a5 Smad4 Smad4 CgPICR_010134 CgPICR_010134 I79_014841 I79_014841 PPARG PPARG I79_015223 I79_015223 I79_015358 I79_015358 I79_015503 I79_015503 Sostdc1 Sostdc1 Acvr2a Acvr2a Smurf1 Smurf1 I79_016051 I79_016051 Twsg1 Twsg1 I79_016483 I79_016483 Tmem145 Tmem145 Gdf3 Gdf3 Fn1 Fn1 Vsir Vsir H671_4g11668 H671_4g11668 I79_017833 I79_017833 Mapk3 Mapk3 I79_018432 I79_018432 I79_019055 I79_019055 Pdcd4 Pdcd4 Ccdc142 Ccdc142 Vstm2a Vstm2a Tgfb1 Tgfb1 I79_021007 I79_021007 Acvrl1 Acvrl1 Spint1 Spint1 Kcnd3 Kcnd3 I79_021786 I79_021786 Col2a1 Col2a1 I79_021938 I79_021938 I79_022080 I79_022080 I79_024341 I79_024341 I79_024959 I79_024959 Adamts7 Adamts7 Dlx1 Dlx1 Msx1 Msx1 Bmpr2 Bmpr2 Hivep1 Hivep1 Msx2 Msx2 Tmem100 Tmem100 Sost Sost I79_000092 I79_000092 I79_000120 I79_000120 Bmp2 Bmp2 Rgma Rgma Usp9x Usp9x I79_025783 I79_025783 Smpd3 Smpd3 I79_025513 I79_025513 I79_025459 I79_025459 I79_025316 I79_025316 Nog Nog Atf2 Atf2 Slc33a1 Slc33a1 Gdf9 Gdf9 I79_004532 I79_004532 I79_005088 I79_005088 Fkbp8 Fkbp8 I79_005100 I79_005100 I79_005573 I79_005573 Ecsit Ecsit Nodal Nodal I79_006254 I79_006254 I79_006745 I79_006745 Smad6 Smad6 Smad3 Smad3 Smad1 Smad1 I79_007088 I79_007088 Ext1 Ext1 Smad2 Smad2 I79_007514 I79_007514 Bmp7 Bmp7 Dlx5 Dlx5 Runx2 Runx2 Cer1 Cer1 Ddx5 Ddx5 Bmp6 Bmp6 Hfe Hfe Fst Fst Id1 Id1 Tgfbr3 Tgfbr3 Egr1 Egr1 Tgfb3 Tgfb3 Smad9 Smad9 Gata5 Gata5 Sfrp1 Sfrp1 Acvr1 Acvr1 I79_010224 I79_010224 Bmp10 Bmp10 Adamts12 Adamts12 I79_010524 I79_010524 Smad5 Smad5 Dlx3 Dlx3 I79_011333 I79_011333
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
HeylHairy/enhancer-of-split related with YRPW motif-like protein. (300 aa)
I79_012218Succinyl-CoA:3-ketoacid-coenzyme A transferase 2A, mitochondrial. (445 aa)
RgmbRGM domain family member B-like protein. (250 aa)
Notch2Neurogenic locus notch-like protein 2. (1521 aa)
Bmp15Bone morphogenetic protein 15. (369 aa)
Smad7Mothers against decapentaplegic-like 7. (256 aa)
Acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (559 aa)
Slc39a5Zinc transporter ZIP5. (539 aa)
Smad4Mothers against decapentaplegic-like 4. (259 aa)
CgPICR_010134Left-right determination factor. (365 aa)
I79_014841Left-right determination factor. (368 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_015223Neurogenic locus notch-like protein 2. (248 aa)
I79_015358Basic helix-loop-helix transcription factor scleraxis. (191 aa)
I79_015503Transcription factor HES-1. (92 aa)
Sostdc1Sclerostin domain-containing protein 1. (193 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
Smurf1E3 ubiquitin-protein ligase SMURF1. (303 aa)
I79_016051Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (777 aa)
Twsg1Twisted gastrulation protein-like 1. (222 aa)
I79_016483Chordin-like protein 1. (427 aa)
Tmem145Multiple epidermal growth factor-like domains 8. (2639 aa)
Gdf3Growth/differentiation factor 3. (361 aa)
Fn1Fibronectin. (2486 aa)
VsirPlatelet receptor Gi24. (271 aa)
H671_4g11668Chordin. (842 aa)
I79_017833Lymphoid enhancer-binding factor 1. (276 aa)
Mapk3Mitogen-activated protein kinase. (408 aa)
I79_018432Homeobox protein NANOG. (490 aa)
I79_019055Alkaline phosphatase. (547 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
Ccdc142Coiled-coil domain-containing protein 142. (723 aa)
Vstm2aV-set and transmembrane domain-containing protein 2A. (236 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
I79_021007Potassium voltage-gated channel subfamily D member 3. (254 aa)
Acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (776 aa)
Spint1Kunitz-type protease inhibitor 1. (499 aa)
Kcnd3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (369 aa)
I79_021786Collagen alpha-1(II) chain. (689 aa)
Col2a1Collagen alpha-1(II) chain. (709 aa)
I79_021938Mothers against decapentaplegic-like 1. (122 aa)
I79_022080Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (402 aa)
I79_024341Paired mesoderm homeobox protein 2B. (182 aa)
I79_024959Mothers against decapentaplegic-like 1. (161 aa)
Adamts7A disintegrin and metalloproteinase with thrombospondin motifs 7. (916 aa)
Dlx1Homeobox protein DLX-1. (255 aa)
Msx1Homeobox protein MSX-1. (261 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Hivep1Zinc finger protein 40. (2692 aa)
Msx2Homeobox protein MSX-2. (267 aa)
Tmem100Transmembrane protein 100. (134 aa)
SostSclerostin. (213 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
I79_000120Bone morphogenetic protein 5. (260 aa)
Bmp2Bone morphogenetic protein 2. (272 aa)
RgmaRepulsive guidance molecule A. (414 aa)
Usp9xPutative ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2558 aa)
I79_025783Mothers against decapentaplegic-like 1. (97 aa)
Smpd3Sphingomyelin phosphodiesterase 3. (446 aa)
I79_025513Mothers against decapentaplegic-like 1. (151 aa)
I79_025459Mothers against decapentaplegic-like 1. (117 aa)
I79_025316Mothers against decapentaplegic-like 1. (104 aa)
NogNoggin. (117 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2. (487 aa)
Slc33a1Acetyl-coenzyme A transporter 1. (550 aa)
Gdf9Growth/differentiation factor 9. (258 aa)
I79_004532Hemojuvelin. (597 aa)
I79_005088Cartilage oligomeric matrix protein. (585 aa)
Fkbp8Peptidylprolyl isomerase. (405 aa)
I79_005100Growth/differentiation factor 15. (96 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
EcsitEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial. (430 aa)
NodalNodal. (309 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
I79_006745Mothers against decapentaplegic-like 6. (71 aa)
Smad6Mothers against decapentaplegic-like 6. (174 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Smad1Mothers against decapentaplegic-like 1. (232 aa)
I79_007088Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (870 aa)
Ext1Exostosin-1. (388 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
I79_007514Growth/differentiation factor 5. (253 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Dlx5Homeobox protein DLX-5. (289 aa)
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
Cer1Cerberus. (272 aa)
Ddx5Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (615 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
HfeHereditary hemochromatosis protein-like; Belongs to the MHC class I family. (306 aa)
FstFollistatin. (316 aa)
Id1DNA-binding protein inhibitor ID-1. (157 aa)
Tgfbr3TGF-beta receptor type III. (849 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
Smad9Mothers against decapentaplegic homolog. (465 aa)
Gata5Transcription factor GATA-5. (406 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Acvr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
I79_010224BMP-binding endothelial regulator protein. (371 aa)
Bmp10Bone morphogenetic protein 10. (399 aa)
Adamts12A disintegrin and metalloproteinase with thrombospondin motifs 12. (171 aa)
I79_010524A disintegrin and metalloproteinase with thrombospondin motifs 12. (1148 aa)
Smad5Mothers against decapentaplegic homolog. (462 aa)
Dlx3Homeobox protein DLX-3. (287 aa)
I79_011333Sphingomyelin phosphodiesterase 3. (410 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.