(27 nodes) Leukocyte apoptotic process network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Dnaja3	DnaJ-like subfamily A member 3, mitochondrial. (453 aa)
	Bak1	Bcl-2-likeous antagonist/killer. (209 aa)
	I79_001046	Neurofibromin. (2164 aa)
	H671_5g14837	Tumor necrosis factor ligand superfamily member 6-like isoform 1; Belongs to the tumor necrosis factor family. (192 aa)
	I79_003468	Bcl-2-like protein 11. (141 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	Chek2	Serine/threonine-protein kinase Chk2. (539 aa)
	Pkn1	Serine/threonine-protein kinase N1; Belongs to the G-protein coupled receptor 2 family. (1696 aa)
	Dffa	DNAation factor subunit alpha. (119 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Bcl10	B-cell lymphoma/leukemia 10. (232 aa)
	Ripk1	Receptor-interacting serine/threonine-protein kinase 1. (655 aa)
	Kdelr1	ER lumen protein retaining receptor 1. (61 aa)
	I79_020697	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (980 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	Lmbr1l	Protein LMBR1L; Belongs to the LIMR family. (489 aa)
	I79_015109	Interleukin-6. (174 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Plekho2	Pleckstrin-likey domain-containing family O member 2. (494 aa)
	Tnfrsf21	Tumor necrosis factor receptor superfamily member 21. (654 aa)
	Fas	Tumor necrosis factor receptor superfamily member 6. (124 aa)
	H671_3g9857	Tumor necrosis factor receptor superfamily member 6-like protein. (170 aa)
	I79_012741	Kinesin-associated protein 3. (610 aa)
	Crkl	Crk-like protein. (303 aa)
	Kitlg	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	Bcl11b	B-cell lymphoma/leukemia 11B. (812 aa)
	Traf3ip2	Adapter protein CIKS. (560 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Bcl10	G3H397	G3IMU1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	B-cell lymphoma/leukemia 10.	0.403
Akt1	Gli3	G3H397	G3HVA3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Zinc finger protein GLI3.	0.458
Akt1	I79_003468	G3H397	G3H020	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Bcl-2-like protein 11.	0.439
Akt1	I79_015109	G3H397	G3HVW6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interleukin-6.	0.599
Akt1	I79_020089	G3H397	G3I954	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase-9; Belongs to the peptidase C14A family.	0.778
Akt1	Kitlg	G3H397	G3HII0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.448
Akt1	Myc	G3H397	G3IP28	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein.	0.528
Bak1	I79_003468	A1E3K4	G3H020	Bcl-2-likeous antagonist/killer.	Bcl-2-like protein 11.	0.916
Bak1	I79_020089	A1E3K4	G3I954	Bcl-2-likeous antagonist/killer.	Caspase-9; Belongs to the peptidase C14A family.	0.604
Bcl10	Akt1	G3IMU1	G3H397	B-cell lymphoma/leukemia 10.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.403
Bcl10	Ripk1	G3IMU1	G3IEG4	B-cell lymphoma/leukemia 10.	Receptor-interacting serine/threonine-protein kinase 1.	0.423
Crkl	I79_020089	G3HFZ9	G3I954	Crk-like protein.	Caspase-9; Belongs to the peptidase C14A family.	0.403
Dffa	I79_020089	G3IQ86	G3I954	DNAation factor subunit alpha.	Caspase-9; Belongs to the peptidase C14A family.	0.546
Fas	H671_5g14837	G3HQY4	G3GZK5	Tumor necrosis factor receptor superfamily member 6.	Tumor necrosis factor ligand superfamily member 6-like isoform 1; Belongs to the tumor necrosis factor family.	0.921
Fas	I79_020089	G3HQY4	G3I954	Tumor necrosis factor receptor superfamily member 6.	Caspase-9; Belongs to the peptidase C14A family.	0.540
Fas	Ripk1	G3HQY4	G3IEG4	Tumor necrosis factor receptor superfamily member 6.	Receptor-interacting serine/threonine-protein kinase 1.	0.720
Gli3	Akt1	G3HVA3	G3H397	Zinc finger protein GLI3.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.458
H671_3g9857	H671_5g14837	G3HQY3	G3GZK5	Tumor necrosis factor receptor superfamily member 6-like protein.	Tumor necrosis factor ligand superfamily member 6-like isoform 1; Belongs to the tumor necrosis factor family.	0.921
H671_3g9857	I79_020089	G3HQY3	G3I954	Tumor necrosis factor receptor superfamily member 6-like protein.	Caspase-9; Belongs to the peptidase C14A family.	0.540
H671_3g9857	Ripk1	G3HQY3	G3IEG4	Tumor necrosis factor receptor superfamily member 6-like protein.	Receptor-interacting serine/threonine-protein kinase 1.	0.720