(9 nodes) Proximal tubule development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Heyl	Hairy/enhancer-of-split related with YRPW motif-like protein. (300 aa)
	Aqp1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	Pkd1	Polycystin-1. (3717 aa)
	Commd5	COMM domain-containing protein 5. (224 aa)
	Aqp11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (304 aa)
	Acat1	Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	I79_015223	Neurogenic locus notch-like protein 2. (248 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aqp1	Aqp11	G3HJL7	G3I5E2	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.644
Aqp11	Aqp1	G3I5E2	G3HJL7	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.644
Dll1	Heyl	G3HNT7	G3HN78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.529
Dll1	I79_015223	G3HNT7	G3HW73	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.832
Dll1	Notch2	G3HNT7	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.978
Heyl	Dll1	G3HN78	G3HNT7	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.529
Heyl	Notch2	G3HN78	G3HP78	Hairy/enhancer-of-split related with YRPW motif-like protein.	Neurogenic locus notch-like protein 2.	0.431
I79_015223	Dll1	G3HW73	G3HNT7	Neurogenic locus notch-like protein 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.832
Notch2	Dll1	G3HP78	G3HNT7	Neurogenic locus notch-like protein 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.978
Notch2	Heyl	G3HP78	G3HN78	Neurogenic locus notch-like protein 2.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.431