(83 nodes) Nephron tubule development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_025974	Metastasis suppressor protein 1. (73 aa)
	I79_024070	Heparan sulfate 2-O-sulfotransferase 1. (224 aa)
	Ptch1	Protein patched-like 1. (1114 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	Ctnnbip1	Beta-catenin-interacting protein 1. (81 aa)
	I79_024483	Polycystin-2. (192 aa)
	Umod	Uromodulin. (618 aa)
	Mtss1	Metastasis suppressor protein 1. (526 aa)
	Commd5	COMM domain-containing protein 5. (224 aa)
	Dspp	Dentin sialophosphoprotein. (859 aa)
	I79_025625	Polycystin-2. (318 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	I79_023900	Leucine zipper putative tumor suppressor 2. (449 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Ahi1	Jouberin. (988 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	I79_003731	Iroquois-class homeodomain protein IRX-3. (341 aa)
	Nog	Noggin. (117 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_006364	Kinesin-like protein KIF26B. (158 aa)
	Kif26b	Kinesin-like protein KIF26B. (189 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Lhx1	LIM/homeobox protein Lhx1. (84 aa)
	Mef2c	Myocyte-specific enhancer factor 2C. (465 aa)
	Greb1	Protein GREB1. (1972 aa)
	Pkd1	Polycystin-1. (3717 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	CgPICR_019990	Persephin. (157 aa)
	Hoxa11	Homeobox protein Hox-A11. (250 aa)
	Osr1	Protein odd-skipped-related 1. (266 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	Pgf	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
	I79_009699	GREB1-like protein. (1598 aa)
	I79_009708	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (332 aa)
	Lama5	Laminin subunit alpha-5. (3735 aa)
	Fmn1	Formin-1. (644 aa)
	I79_010448	Formin-1. (1049 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
	Aqp1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	Pbx1	Pre-B-cell leukemia transcription factor 1. (325 aa)
	I79_011731	Serine/threonine-protein kinase WNK4. (1139 aa)
	Heyl	Hairy/enhancer-of-split related with YRPW motif-like protein. (300 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)
	H671_2g6716	Calbindin-like protein. (211 aa)
	I79_012727	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (441 aa)
	I79_012894	Transcription factor AP-2 beta. (287 aa)
	Timeless	Protein timeless-like. (1200 aa)
	Smad4	Mothers against decapentaplegic-like 4. (259 aa)
	Wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	I79_015033	Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
	I79_015223	Neurogenic locus notch-like protein 2. (248 aa)
	I79_015321	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (243 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Acat1	Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	Fat4	Protocadherin Fat 4. (5152 aa)
	Gzf1	GDNF-inducible zinc finger protein 1. (701 aa)
	Aqp11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (304 aa)
	Hnf1b	Hepatocyte nuclear factor 1-beta. (593 aa)
	Tacstd2	Tumor-associated calcium signal transducer 2-like protein. (318 aa)
	Lgr4	Leucine-rich repeat-containing G-protein coupled receptor 4. (231 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Irx2	Iroquois-class homeodomain protein IRX-2. (211 aa)
	Irx1	Iroquois-class homeodomain protein IRX-1. (319 aa)
	Tcf21	Transcription factor 21. (179 aa)
	I79_021155	Paired box protein Pax-2. (503 aa)
	Wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_021721	Protocadherin-16. (3015 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	Pax8	Paired box protein Pax-8. (452 aa)
	I79_022733	Kelch-like protein 3. (427 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Agt	Aqp11	G3GX14	G3I5E2	Angiotensinogen; Belongs to the serpin family.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.473
Aqp1	Aqp11	G3HJL7	G3I5E2	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.644
Aqp11	Agt	G3I5E2	G3GX14	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Angiotensinogen; Belongs to the serpin family.	0.473
Aqp11	Aqp1	G3I5E2	G3HJL7	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.644
CgPICR_019990	Gdnf	G3HCK6	G3HJV8	Persephin.	Glial cell line-derived neurotrophic factor.	0.667
Ctnnb1	Ctnnbip1	G3H996	G3IKH6	Catenin beta-1.	Beta-catenin-interacting protein 1.	0.999
Ctnnb1	Dll1	G3H996	G3HNT7	Catenin beta-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.450
Ctnnb1	Fat4	G3H996	G3I301	Catenin beta-1.	Protocadherin Fat 4.	0.671
Ctnnb1	I79_000973	G3H996	G3GTI9	Catenin beta-1.	Transcription factor SOX-10.	0.781
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	I79_006254	G3H996	G3H7C4	Catenin beta-1.	Bone morphogenetic protein 4.	0.448
Ctnnb1	I79_015321	G3H996	G3HWG4	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.535
Ctnnb1	I79_021721	G3H996	G3IDE3	Catenin beta-1.	Protocadherin-16.	0.607
Ctnnb1	Jag1	G3H996	G3GSA7	Catenin beta-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.457
Ctnnb1	Mef2c	G3H996	G3HAW1	Catenin beta-1.	Myocyte-specific enhancer factor 2C.	0.750
Ctnnb1	Myc	G3H996	G3IP28	Catenin beta-1.	Myc proto-oncogene protein.	0.673
Ctnnb1	Pkd1	G3H996	G3HBQ9	Catenin beta-1.	Polycystin-1.	0.408
Ctnnb1	Smad4	G3H996	G3HTR4	Catenin beta-1.	Mothers against decapentaplegic-like 4.	0.785
Ctnnb1	Sox8	G3H996	G3HBV8	Catenin beta-1.	Transcription factor SOX-8.	0.589
Ctnnb1	Wnt1	G3H996	G3I6J2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.785